Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity

Afrasiabi, Zahra; Sinn, E.; Lin, Wei−Sheng; Ma, Yinfa; Campana, Charles F.; Padhyé, Subhash

doi:10.1016/j.jinorgbio.2005.04.012

Cited by 184 publications

(87 citation statements)

References 25 publications

(24 reference statements)

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16] Hydrazone ligands create an environment similar to the one present in biological systems usually by making coordination through oxygen and nitrogen atoms. Various important properties of carbonic acid hydrazides, along with their applications in medicine and analytical chemistry, have led to increased interest in their complexation characteristics with transition metal ions.…”

Section: Introductionmentioning

confidence: 99%

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

et al. 2012

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3 )] (6). Structural characterization of these compounds 4-6 were accomplished by using various physico-chemical techniques. Single crystal X-ray diffraction data of complexes 4 and 5 proved their distorted square planar geometry. In order to ascertain the potential of the above synthesised compounds towards biomolecular interactions, additional experiments involving interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were carried out. All the ligands and corresponding nickel(II) chelates have been screened for their scavenging effect towards O 2 − , OH and NO radicals. The efficiency of complexes 4-6 to arrest the growth of HeLa, HepG-2 and A431 tumour cell lines has been studied along with the cell viability test against the non-cancerous NIH 3T3 cells under in vitro conditions.

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Section: Introductionmentioning

confidence: 99%

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

et al. 2012

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“…Afrasiabi, et al [47] showed that complexation with nickel ion in semicarbazone derivative increases the inhibitory action on MCF-7 cell proliferation. Similar effect was observed upon complexation of other thiosemicarbazones with nickel (II) ion [48].…”

Section: Experimental Enthalpy Values (∆H) (Kj/g)mentioning

confidence: 99%

Can metal replacement increase the antitumor activity of azurin? (in vitro study)

Ali¹,

Mohamed²,

Sedek³

2017

Gen Med Open

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Azurin is a member of blue-copper proteins family which induces apoptosis in cancer cells. In the present work, azurin (Az) has been modified via replacement of copper at active site with cobalt and nickel. FTIR revealed that its secondary structure is practically indistinguishable from that of its derivatives. UV spectroscopy and DSC results revealed that native form of Az is more stable than Co-and Ni forms. SRB was used to elucidate their possible anti-tumor effect on cancer cell lines from breast and colon cells (MCF-7 and HCT116, respectively). To our best knowledge, this is the first time metal replacement of Az has been used with cell line. It appears that this process is the predominant reason for the effectiveness of Az. Experimental results showed that the anti-tumor activity of Cu-and Co Az (at concentration ≤ 25 µg/L) is higher for colon-relative to breast cells, while that for Ni-Az is higher for both cells (at low concentration, 5 µg/L). Hence, according to our findings it was revealed that Ni-Az form has the most extensive anti-antitumor effect on breast-and colon cancer cells. This highlights that Ni may be bona fide copper ion impersonator in vivo.

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“…The more significant bioactivities of Schiff bases are found in a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes, such as hydroxysemicarbazide showed potential anticancer activity against L1210 murine leukemia cells [2] . Nickel (II) complexes of semicarbazone derivatives showed potent anticancer activity against MCF-7 cell lines [3] . Semicarbazones, thiosemicarbazones demonstrated potent cytotoxicity against different cancer cell lines [4] .…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice

Islam

Ali

Khanam

2013

Asian Pacific Journal of Tropical Biomedicine

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Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity

Cited by 184 publications

References 25 publications

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

Can metal replacement increase the antitumor activity of azurin? (in vitro study)

Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice

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