The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death.
Gadolinium triflate immobilized in room temperature ionic liquids (RTIL) 1-butyl-3methylimidazolium tetrafluoroborate ([bmim][BF 4 ]) and 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF 6 ]) was found to be a recyclable and green catalyst for acetylation of a variety of alcohols, phenols and amines. Acetylation reactions using acetic anhydride (Ac 2 O) as the reagent proceeded in excellent yields in the presence of catalytic amounts (0.2-0.5 mol%) of Gd(OTf) 3 immobilized in RTILs, at ambient temperature. In addition, the catalyst system Gd(OTf) 3 /[bmim][X] can be recovered and reused efficiently in these transformations.
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