Niacin Biosynthesis in Plants

Arditti, Joseph; Tarr, John B.

doi:10.1002/j.1537-2197.1979.tb06328.x

Cited by 10 publications

(3 citation statements)

References 63 publications

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“…The production of tryptophan (also exists as 5‐hydroxytryptophan) as a secondary metabolite by Artemisia species is very important in the sense that it is an essential amino acid and acts as a natural sedative agent responsible for the biosynthesis of several tryptophan‐derived metabolites. It acts as a precursor in the biosynthesis of indole alkaloids (camalexin, a phytoalexin) in plants (Glawischnig, Hansen, Olsen, & Halkier, ), melatonin, and serotonin biosynthesis (a neurotransmitter regulates sleep, mood, and appetite) and promote niacin biosynthesis in plants, even though inefficiently, in mammals (Arditti & Tarr, ). Iven studied insight into root‐specific early defenses and found tryptophan‐derived metabolites as active antifungal compounds against a vascular pathogen (Iven et al, ).…”

Section: The Chemistry and Pharmacology Of Artemisia Alkaloids/alliedmentioning

confidence: 99%

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

Rashid

Alamzeb²,

Ali³

et al. 2019

Phytotherapy Research

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Several reviews have been published on Artemisia's derived natural products, but it is the first attempt to review the chemistry and pharmacology of more than 80 alkaloids and allied nitrogen compounds obtained from various Artemisia species (covering the literature up to June 2018). The pharmacological potential and unique skeleton types of certain Artemisia's alkaloids provoke the importance of analyzing Artemisia species for bioactive alkaloids and allied nitrogen compounds. Among the various types of bioactive Artemisia's alkaloids, the main classes were the derivatives of rupestine (pyridine–sesquiterpene), lycoctonine (diterpene), pyrrolizidine, purines, polyamine, peptides, indole, piperidine, pyrrolidine, alkamides, and flavoalkaloids. The rupestine derivatives are Artemisia's characteristic alkaloids, whereas the rest are common alkaloids found in the family Asteraceae and chemotaxonomically links the genus Artemisia with the tribes Anthemideae. The most important biological activities of Artemisia's alkaloids are including hepatoprotective, local anesthetic, β‐galactosidase, and antiparasitic activities; treatment of angina pectoris, opening blocked arteries, as a sleep‐inducing agents and inhibition of HIV viral protease, CYP450, melanin biosynthesis, human carbonic anhydrase, [3H]‐AEA metabolism, kinases, and DNA polymerase β1. Some of the important nitrogen metabolites of Artemisia include pellitorine, zeatin, tryptophan, rupestine, and aconitine analogs, which need to be optimized and commercialized further.

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Section: The Chemistry and Pharmacology Of Artemisia Alkaloids/alliedmentioning

confidence: 99%

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

Rashid

Alamzeb²,

Ali³

et al. 2019

Phytotherapy Research

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“…Several reports have suggested that the tryptophan pathway is operative, whereas others have maintained that it is not. These differences in opinion are due to the fact that some research was carried out without the use of labelled precursors and other work did not utilize appropriate organisms, techniques or metabolites (for a review see Arditti and Tarr, 1979). The work reported here was carried out to overcome some of these difficulties and obtain information on the pathways of niacin biosynthesis in angiosperms and on the metabolism of orchid seedlings.…”

Section: Introductionmentioning

confidence: 99%

NIACIN BIOSYNTHESIS IN LEAF DISCS AND SEEDLINGS OF CATTLEYA SKINNERI (ORCHIDACEAE)

et al. 1982

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“…Therefore, its catabolism is of considerable interest as a pathway for the biosynthesis of the vitamin and its coenzymes. The role of tryptophan and that of other potential precursors in the biosynthesis of niacin in plants (especially angiosperms) is still unclear however (Arditti and Tarr, 1979), and requires further research. Therefore, a rapid and sensitive assay for the intermediates of tryptophan catabolism in plants, suitable for use with small samples, is highly desirable.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Tryptophan and Its Metabolites by Reverse‐phase High‐pressure Liquid Chromatography

Tarr

Arditti

1981

New Phytologist

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SUMMARYRapid separation and determination of tryptophan, N^-formylkynurenine, kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, nicotinic acid, nicotinamide, trigonelline, kynurenic acid and xanthurenic acid from pea seedling using reverse-phase high-pressure liquid chromatography is described. Accuracy of the determinations was better than 5 % and less than 50 pmol of each metabolite could be measured reliably.

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Niacin Biosynthesis in Plants

Abstract: A review of the literature on niacin biosynthesis in plants generally and angiosperms in particular reveals that the available evidence does not conclusively favor or exclude any of the known pathways.

Cited by 10 publications

References 63 publications

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

NIACIN BIOSYNTHESIS IN LEAF DISCS AND SEEDLINGS OF CATTLEYA SKINNERI (ORCHIDACEAE)

Analysis of Tryptophan and Its Metabolites by Reverse‐phase High‐pressure Liquid Chromatography

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