Niacin and the Schizophrenic Patient

Negative Findings with Nicotinic Acid in the Treatment of Schizophrenias

“…This was further sub stantiated by the favorable therapeutic findings with nicotinic acid by several independent investigators, e.g. Alvarez (1967); Cott (1967); Denson (1962); Herjanic et al (1967); Maslowski (1961); Newbold (1970); Robie (1971); Saarma andVasar (1970), andTobin (1967). Nevertheless, at variance with the reported beneficial therapeutic findings with nicotinic acid, Ashby et al (1960) found no therapeutic effects with nicotinamide in chronic schizophrenic patients and McGarth et al (1972) have failed to show any significant difference in therapeutic results between patients on the active (nicotinamide) and inactive (placebo) tablets 2 years after the commencement of drug administration.…”

Evaluation of a detoxification regimen for fat stored xenobiotics

“…(62)(63)(64) It is unclear why these phenomenon appear, but it is clear that simple vasodilation is an inadequate theory for these flushes. (65) It has been suggested that the reported side effects of niacin may actually be the creation of other vitamin and mineral imbalances, (36) a theory which can not be refuted on the basis of this study, as negative side effects were not noted when correct proportions were administered.…”

“…Niacin has been shown to reduce dyspnea in paraquat poisoned rats. (24) Niacin administration has also been found to lower cholesterol levels, (64) and is the probable cause for lowered cholesterol levels in program participants. Vitamin C affords protection against enzyme activity alterations and histological changes caused by PCB toxicity.…”