Next Generation Biodegradable Ureteral Stent in a Yucatan Pig Model

Chew, Ben H.; Lange, Dirk; Paterson, Ryan F.; Hendlin, Kari; Monga, Manoj; Clinkscales, Kenneth W.; Shalaby, Shalaby W.; Hadaschik, Boris

doi:10.1016/j.juro.2009.09.073

Cited by 58 publications

(50 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Uriprene stents degraded from the distal to the proximal portion, which can maintain ureteral patency. [15][16][17] In the present study, our stents comprising two different parts can also degrade in an orderly manner. The dynamic degradation of previous stents were detected on X-ray.…”

Section: Discussionmentioning

confidence: 76%

“…The biodegradable Uriprene stents were investigated in vivo in a porcine model. [15][16][17] Although the first-and secondgeneration Uriprene stents are imperfect because of their unevenness or inappropriate degradation time, the thirdgeneration Uriprene stent is a safe and effective alternative to biostable stents. However, the production process of Uriprene stents is very complicated, which might affect its cost and uniformity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Braided thin‐walled biodegradable ureteral stent: Preliminary evaluation in a canine model

et al. 2013

View full text Add to dashboard Cite

Abbreviations & AcronymsObjectives: To evaluate a novel designed degradable ureteral stent. Methods: A total of 24 male Beagles, each with bilateral stents implanted (a biodegradable ureteral 4.5-Fr stent and a standard 4-Fr biostable stent) were divided into four groups. Intravenous pyelography, B-mode ultrasonography, and blood and urine tests were carried out before the procedure (0 weeks), and at 1-, 2-, 3-and 4-week intervals. Meanwhile, the mechanical characteristics of stents were tested, and scanning electron microscopy images of the biodegradable braided stents were obtained at different time-points postoperatively. In addition, histopathological changes were compared between the two different stents. Results: All biodegradable braided stents began degrading at 1 week, and had completely degraded by 4 weeks. Hydronephrosis was equivalent during the first 2 weeks, but less with the biodegradable stents than with the control biostable stents at 3 and 4 weeks. Preoperative and postoperative blood and urine results were similar. The mechanical properties of the biodegradable stents were better than conventional biostable stents. Scanning electron microscopy images obtained at different weekly intervals showed that stents degraded in a predictable fashion. Histological testing of the urinary tract showed that the stent-related tissue reactivity of the two different stents were similar. Conclusions: Our novel braided thin-walled biodegradable stents provide temporary renal drainage as good as commercially available biostable stents. They also have good biocompatibility and physical characteristics. Therefore, they might have clinical application.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Braided thin‐walled biodegradable ureteral stent: Preliminary evaluation in a canine model

et al. 2013

View full text Add to dashboard Cite

show abstract

“…(Lingeman, Preminger et al 2003) The authors are currently involved in developing a new biodegradable stent (Poly-Med Inc., Anderson, SC) that dissolves within 1 to 4 weeks in a porcine model. The animals stented with degradable stents displayed less histologic inflammation than animals stented with control polyurethane biostable Double J stents (Chew, Lange et al 2010). Weekly intravenous pyelograms displayed less hydronephrosis in the degradable stent group.…”

Section: Biodegradable Stentsmentioning

confidence: 86%

Biomaterials in Urology - Beyond Drug Eluting and Degradable - A Rational Approach to Ureteral Stent Design

Lange¹,

Elwood²,

Chew³

2011

Biomaterials - Physics and Chemistry

Self Cite

View full text Add to dashboard Cite

“…8 Chew et al invented several types of degradable Uriprene™ ureteral stents with undesirable results due to uncontrollable degradation, which involved the sudden disintegration of material and caused transient obstruction in animal trials. [9][10][11] Fu and coworkers produced a polylactide (PLA) ureteral stent, and the animal trials validated that it required more than 80 days…”

Section: Introductionmentioning

confidence: 99%

“…10 The placement of a ureteral stent can cause hydronephrosis, and this is a natural response to the indwelling stent, even in the absence of an obstruction disease.…”

mentioning

confidence: 99%

Characterization of nanostructured ureteral stent with gradient degradation in a porcine model

Wang¹,

Shan²,

Wang³

et al. 2015

IJN

View full text Add to dashboard Cite

A tubular poly(ε-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) ureteral stent composed of nanofibers with micropores was fabricated by double-needle electrospinning. The stent was ureteroscopically inserted into six Changbai pigs, and the commercial polyurethane Shagong ® stent was inserted into four pigs as control. Intravenous pyelography revealed that the PCL/PLGA stent gradually degraded from the distal end to proximal terminal, and all stents were completely degraded at 10 weeks post-insertion. No significant difference was observed in hydronephrosis severity between the two groups. The levels of serum creatinine and urine pH remained similar throughout the study in the two groups, but the number of white blood cells in the urine was significantly higher in the Shagong ® stent group. On Day 70, histological evaluation indicated equivalent histological severity scores in the middle and distal ureter sections and bladder in the two groups. However, the PCL/PLGA stent-implanted pigs had significantly lower mean severity scores in the kidney and proximal ureter sites. These data revealed that the PCL/PLGA stent degraded in a controlled manner, did not induce obstruction, and had a lower urothelial impact in comparison to the Shagong ® stent, indicating that the stent exhibited great potential for clinical application.

show abstract

Next Generation Biodegradable Ureteral Stent in a Yucatan Pig Model

Abstract: Our study confirms that Uriprene stents are biocompatible and provide good renal drainage. They hold promise for decreasing the need for a secondary procedure and stent related morbidity, such as infection and irritative symptoms.

Cited by 58 publications

References 13 publications

Braided thin‐walled biodegradable ureteral stent: Preliminary evaluation in a canine model

Braided thin‐walled biodegradable ureteral stent: Preliminary evaluation in a canine model

Biomaterials in Urology - Beyond Drug Eluting and Degradable - A Rational Approach to Ureteral Stent Design

Characterization of nanostructured ureteral stent with gradient degradation in a porcine model

Contact Info

Product

Resources

About