Biomaterials in Urology - Beyond Drug Eluting and Degradable - A Rational Approach to Ureteral Stent Design

Lange, Dirk; Elwood, Chelsea; Chew, Ben H.

doi:10.5772/24209

Cited by 6 publications

(8 citation statements)

References 89 publications

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“…Ureteral stents can be incorporated with drugs and other materials to assist patient comfort and/or to forestall encrustation. Drug-loaded stents liberate medications that perform locally on the bladder to reduce irritation and pain [7,8]. To date, various approaches have been employed in an attempt to do so and have focused on developing novel surface coatings and drug-elution strategies.…”

Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents

Lin¹,

Liu

Lee

et al. 2018

Journal of Nanomaterials

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We develop novel analgesic-eluting nanofiber-incorporated ureteral stents that offer sustained release of lidocaine and ketorolac for local drug delivery. Lidocaine and poly(D,L)-lactide-co-glycolide (PLGA) were dissolved in hexafluoroisopropanol and were electrospun into nonwoven nanofibers onto the surface of ureteral stents. This was followed by electrospinning of another layer of PLGA nanofibers containing ketorolac. Electrospun drug-loaded nanofibers were then characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and water contact angle analysis. In addition, the elution behavior characteristics of the analgesics, both in vivo and in vitro, from the nanofiber-incorporated stents were evaluated. Experimental results indicate that the analgesic-eluting ureteral stents could liberate high strengths of analgesics in vitro and in vivo for at least 50 and 30 days, respectively. The analgesic-eluting nanofiber-incorporated ureteral stents are potentially applicable for alleviating the discomfort associated with stent implant.

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Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents

Lin¹,

Liu

Lee

et al. 2018

Journal of Nanomaterials

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“…в 1989 г., который может быть использован у женщин без рент геновского и эндоскопического контроля [13], но стоимость магнитных стентов является немаловажным фактором [14]. Биодеградируемые стенты [15], к сожалению, ввиду слабой управляемости деградации не получили широкого распространения [16]. Стент с нитями [17] -при влекательная опция, но из-за высокой частоты инцидентального выпадения также не являются оптимальным вариантом.…”

Section: Discussionunclassified

A new ultrasound guided method for ureteral stent removal in women after lithotripsy

Gadzhiev¹,

Brovkin²,

Grigor'ev³

et al. 2016

Androl. genit. hir.

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Цель исследования-разработать быстрый, удобный и в то же время безопасный метод удаления мочеточниковых стентов у женщин после дробления камней. Материалы и методы. С февраля 2014 г. по март 2016 г. проведено ретроспективное мультицентровое исследование, включающее 122 пациентки после дробления камней: 46-в контрольной группе (стент был удален стандартным способом-цистоскопом 22 Сн) и 76-в экспериментальной группе (стент был удален с помощью «спиралевидного устройства» 15 Сн под ультразвуковым контролем). Критериями исключения явились: пролапс тазовых органов ≥ II по шкале POPQ и осложненные стенты (со смещением или инкрустацией). Оценивали длительность удаления стентов, сумму баллов по визуальной аналоговой шкале боли, а также вероятность развития осложнений. Результаты. У всех исследуемых пациентов стенты были успешно удалены. Осложнений в обеих группах не зарегистрировано. Продолжительность удаления стента в экспериментальной группе была выше, чем в контрольной, примерно на 4 с (p = 0,0056). Различие было статистически значимым, однако клинически не важным. Наиболее существенным оказалось различие в оценке по визуальной аналоговой шкале в пользу экспериментальной группы (p = 4 × 10-5). Заключение. Предложенный метод удаления стентов петлей под ультразвуковым контролем у женщин после дробления камней оказался более комфортным-с меньшим числом баллов по визуальной аналоговой шкале по сравнению склассическим удалением с помощью цистоскопа, не требующим дополнительных затрат, связанных с использованием эндоскопического оборудования, стерилизацией последнего, а также рабочего времени сестры, что делает его привлекательной опцией в амбулаторной практике в неосложненных случаях, а будучи лишенным ионизирующего излучения, может быть рекомендован для удаления стентов у беременных пациенток.

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“…In these cases, biofilm formation arises due to the deposition of a urinary conditioning film, composed by urinary proteins, ions and crystals at the stent's surface, which favors the interaction and adhesion of bacteria to the stent surface. [12,13] Within biofilm environment, microorganisms are protected from the action of host defenses and antibiotics. [14] In a clinical study, it was found that the most common bacteria found on urinary stent surface biofilms are Escherichia coli, Enterococcus spp.…”

Section: Clinical Needmentioning

confidence: 99%

“…However, this biodegradable design presented higher migration and bacteriuria rates than the ones obtained with the biostable BraidStent. [135] On the other hand, Jin et al 11 and Zhang et al 12 assessed their BUS design in dogs. Jin's stent provided equal drainage as a standard double J ureteral stents and degraded completely by the 5 th week of follow-up, although bulky fragments of the stent were observed during the degradation.…”

Section: Disruption Of Biofilm Architecturementioning

confidence: 99%

Future Directions for Ureteral Stent Technology: From Bench to the Market

Domingues

Pacheco

Cruz

et al. 2021

Advanced Therapeutics

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Ureteral stents are broadly used for the treatment of a wide range of pathologies, with different complexities and characteristics. Despite being efficient, the morbidity associated with stents, such as bacterial infection and pain, limits their therapeutic action and often represents an increase in healthcare costs. As no single solution fits all problems, there is still a need to improve these medical devices. Throughout this review, the most recent innovations are outlined and suggestions regarding future directions for ureteral stent technology are formulated with respect to materials, coatings, and designs of these devices. As highlighted here, during the process of passing these innovations to the growing market of ureteral stents, one of the biggest challenges is to increase the predictive value of the in vitro assays and, consequently, reduce the number of in vivo tests needed. Thus, recommendations concerning in vitro standard testing of these devices are provided, with focus on medium, flow conditions, and microbiological parameters. Additionally, the reader is also presented with insights about a crucial but rarely discussed topic, the bureaucratic part of the bench to market process, particularly the product certification legislation in Europe.

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Biomaterials in Urology - Beyond Drug Eluting and Degradable - A Rational Approach to Ureteral Stent Design

Cited by 6 publications

References 89 publications

In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents

In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents

A new ultrasound guided method for ureteral stent removal in women after lithotripsy

Future Directions for Ureteral Stent Technology: From Bench to the Market

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