Characterization of nanostructured ureteral stent with gradient degradation in a porcine model

Wang, Xiaoqing; Shan, Hongli; Wang, Jixue; Hou, Yuchuan; Ding, Jianxun; Chen, Qihui; Wang, Handong; Chen, Xuesi

doi:10.2147/ijn.s80810

Cited by 39 publications

(37 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vivo animal experiment exhibited that the stent could completely degrade within 10 weeks post-insertion, and degrade from distal to proximal. Moreover, compared to a commercial stent, this stent showed less impact on epithelial cells (Wang et al, 2015a).…”

Section: Synthetic Polymersmentioning

confidence: 83%

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

Drug eluting ureteral stent is an effective means for local drug delivery to the urinary tract. It can potentially solve a variety of upper urinary tract problems, such as stent-related urinary tract infections and discomfort, ureteral stricture, and neoplastic diseases. However, the release of drug elutes on the surface of biostable stents is unsustainable and uncontrollable. With the development of biomaterial science, the emergence of biodegradable ureteral stents (BUSs) provides a new approach for local drug delivery in the urinary tract. The drugs can be continuously released in a controlled manner from a drug-eluting BUS, when the stent degrades. Especially for the delivery of anti-tumor drugs, the stents can obviously improve the therapeutic effectiveness of the drugs by prolonging the contact duration of the drug and tumor cells. In addition, a secondary stent removal procedure can be avoided. The purpose of this review article is to provide an overview of anti-tumor drug-eluting BUSs and discuss the biomaterials and drug delivery systems of BUS that are currently being developed to deliver anti-tumor drugs for upper tract urothelial carcinoma.

show abstract

Section: Synthetic Polymersmentioning

confidence: 83%

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…This has therapeutic potential in reducing tissue inflammation, edema, and the resultant symptoms in a patient. [47]…”

Section: Biodegradable Stent Technologymentioning

confidence: 99%

Nanotechnology in Urology

Jayasimha

2017

Indian J Urol

View full text Add to dashboard Cite

Introduction:Nanotechnology has revolutionized our approach to medical diagnostics as well as therapeutics and has spanned an entirely new branch of research. This review addresses the potential applications of Nanotechnology in Urology. This article is based on the Dr. Sitharaman Best Essay award of the Urological Society of India for 2016.Methods:A PubMed search was performed for all relevant articles using the terms, “nanotechnology, nanoparticles, nanoshells, nanoscaffolds, and nanofibers.”Results:The developments in diagnostics include novel techniques of imaging of genitourinary malignancies, prostate-specific antigen measurement, early detection of mutations that are diagnostic for polycystic kidney disease. The potential applications of nanotechnology are in the targeted therapy of genitourinary malignancies, erectile dysfunction, overactive bladder, bladder reconstruction, construction of artificial kidneys and biodegradable stents as well as in robotic surgery.Conclusions:Nanotechnology is a rapidly emerging branch of research in urology with diverse and clinically significant applications in diagnostics as well as therapeutics.

show abstract

“…Besides, the PCL/PLGA stent was also placed into the ureter. Although it showed excellent biocompatibility, a few stent-associated symptoms were still observed [13,14]. Therefore, there is an urgent need to develop a stent that can overcome these limitations and prevent or reduce the associated complications.…”

Section: Introductionmentioning

confidence: 99%

Ureteral anastomosis with a polyimide stent in rat kidney transplantation

et al. 2020

View full text Add to dashboard Cite

Background: Complications associated with ureteral anastomosis in kidney transplantation are highly prevalent, despite the development of various types of stents. The current stent materials and placement methods have several limitations. This study attempts to provide an alternative by investigating ureteral anastomosis with a polyimide stent and a modified placement method in a rat model of kidney transplantation. Methods: Sprague-Dawley rats were randomly divided into Group I: sham operation, Group II: autologous ureteral anastomosis, and Group III: isogenic kidney transplantation with ureteral anastomosis. For the anastomosis, a polyimide stent with a previously placed 11-0 silk was inserted into the ureter. The stent and ureter were fixed with 11-0 silk sutures. The kidney weight and serum creatinine were recorded. The ureteral and renal sections were taken for histological analysis. Results: None of the stents had migrated. Urethral patency was achieved. Further, there were no evident histological changes in the anastomosed ureters. The serum creatinine level in group III was significantly higher than the other two groups, but there was no significant difference in kidney weight among the groups at postoperative week 12. Finally, the histological structure of kidneys in groups II and III only showed minor changes. Conclusions: The current anastomosis method with polyimide stent causes minimal damage to the ureteral walls and minimizes the possibility of stent migration. Therefore, this method of ureteral anastomosis with the polyimide stent should be explored for its potential benefits in more animal kidney transplantation models, thus providing an alternative for the clinical setting.

show abstract

Characterization of nanostructured ureteral stent with gradient degradation in a porcine model

Cited by 39 publications

References 40 publications

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

Nanotechnology in Urology

Ureteral anastomosis with a polyimide stent in rat kidney transplantation

Contact Info

Product

Resources

About