Newbouldiaquinone A: A Naphthoquinone—Anthraquinone Ether Coupled Pigment, as a Potential Antimicrobial and Antimalarial Agent from Newbouldia laevis.

Eyong, Kenneth O.; Folefoc, Gabriel N.; Kuete, Victor; Beng, Véronique Penlap; Krohn, Karsten; Hussain, Hidayat; Nkengfack, Augustin Ephram; Saeftel, Michael; Sarite, Salem Ramadan; Hoerauf, Achim

doi:10.1002/chin.200626157

Cited by 8 publications

(7 citation statements)

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“…Flavonoids (detected in all the seeds extracts) are known to be synthesized by plants in response to microbial infection (Fogliani et al, 2005); therefore their potential in vitro antimicrobial effectiveness against a wide array of microorganisms should not come as a surprise, but activity of immature seeds (not containing them) and the low or near lack of activity of ripe fruit (which contain them) point to other factors at play. The same could be said about most phytochemicals detected by the qualitative chemical analysis and known from works in other plant species to have antimicrobial pharmacological activity: tannins (Ahmet Ayaz et al, 2008), steroids (Nawaz Khan et al, 2007), pigments (Fogliani et al, 2005;Eyong et al, 2006) and flavonoids (Fogliani et al, 2005), alkaloids (Yan et al, 2008) and iridoids (Akunvili et al, 1991). Iridoids, present in the aqueous samples only, could contribute to their better performance compared to the acetone extracts.…”

Section: Discussionmentioning

confidence: 88%

Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine

Marzouk

Décor

et al. 2009

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 88%

Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine

Marzouk

Décor

et al. 2009

Journal of Ethnopharmacology

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“…Feature 11.34\411.0882 had a m/z that matched to newbouldiaquinone A, a metabolite from the medicinal plant Newbouldia laevis that is a naphthoquinone−anthroquinone coupled pigment. 48 11.34\587.2077 was matched with blestrianol C, a biphenanthrene isolated from the tubers of the orchid Bletillla striata. 49 Alternatively, the latter two features may be derived from the same unknown metabolite as they share the same retention time, indicating that 11.34\411.0882 could be a fragment ion of 11.34\587.2077.…”

Section: ■ Results and Discussionmentioning

confidence: 94%

Comparative Metabolite Profiling ofSolanum tuberosumagainst Six WildSolanumSpecies with Colorado Potato Beetle Resistance

Tai

Worrall

Pelletier

et al. 2014

J. Agric. Food Chem.

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The Colorado potato beetle Leptinotarsa decemlineata (Say) (CPB) is a coleopteran herbivore that feeds on the foliage on Solanum species, in particular, potato. Six resistant wild Solanum species were identified, and two of these species had low levels of glycoalkaloids. Comparative analysis of the untargeted metabolite profiles of the foliage using UPLC-qTOF-MS was done to find metabolites shared between the wild species but not with Solanum tuberosum (L.) to identify resistance-related metabolites. It was found that only S. tuberosum produced the triose glycoalkaloids solanine and chaconine. Instead, the six wild species produced glycoalkaloids that shared in common tetrose sugar side chains. Additionally, there were non-glycoalkaloid metabolites associated with resistance including hydroxycoumarin and a phenylpropanoid, which were produced in all wild species but not in S. tuberosum.

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“…Table 2 gives the tested quinones presenting low or no activity in vitro against various strains of P. falciparum. [11,41,63,75,76]…”

Section: Other Phenolic Derivativesmentioning

confidence: 99%

Antimalarial compounds isolated from plants used in traditional medicine

2009

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Objectives This review covers the compounds with antiplasmodial activity isolated from plants published from 2005 to the end of 2008, organized according to their phytochemical classes. Details are given for substances with IC50 values 11 mM. Key findings Malaria is a major parasitic disease in many tropical and subtropical regions and is responsible for more than 1 million deaths each year in Africa. The rapid spread of resistance encourages the search for new active compounds. Nature and particularly plants used in traditional medicine are a potential source of new antimalarial drugs as they contain molecules with a great variety of structures and pharmacological activities. Summary A large number of antimalarial compounds with a wide variety of structures have been isolated from plants and can play a role in the development of new antimalarial drugs. Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties.

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Newbouldiaquinone A: A Naphthoquinone—Anthraquinone Ether Coupled Pigment, as a Potential Antimicrobial and Antimalarial Agent from Newbouldia laevis.

Abstract: vis. -(EYONG, K. O.; FOLEFOC*, G. N.; KUETE, V.; BENG, V. P.; KROHN, K.; HUSSAIN, H.; NKENGFACK, A. E.; SAEFTEL, M.; SARITE, S. R.; HOERAUF, A.; Phytochemistry 67 (2006) 6, 605-609; Dep. Org. Chem., Univ. Yaounde, Yaounde, Cameroon; Eng.) -Lindner 26-157

Cited by 8 publications

References 1 publication

Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine

Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine

Comparative Metabolite Profiling ofSolanum tuberosumagainst Six WildSolanumSpecies with Colorado Potato Beetle Resistance

Antimalarial compounds isolated from plants used in traditional medicine

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