New Viral Agents Recovered From Tissue Cultures of Monkey Kidney Cells

Hull, Robert N.; Minner, James R.; Mascoli, Carmine C.

doi:10.1093/oxfordjournals.aje.a119947

Cited by 63 publications

(33 citation statements)

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“…Further isolates have been described that are more similar to human species B viruses (SA5 [19]) or are genetically distinct and are classified provisionally into two separate (simian) enterovirus species, SEV-A and -B (8,9,23,26,27,29,30). These OWM-derived enteroviruses were originally isolated in the 1950s to 1960s from primate cell cultures during the development of tissue culture methods or from clinical specimens obtained from captive or wild-caught primates extensively used in biomedical research.…”

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confidence: 99%

Detection and Genetic Characterization of Enteroviruses Circulating among Wild Populations of Chimpanzees in Cameroon: Relationship with Human and Simian Enteroviruses

Harvala

Sharp

Ngole

et al. 2011

J Virol

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Enteroviruses (EVs), members of the family Picornaviridae, are a genetically and antigenically diverse range of viruses causing acute infections in humans and several Old World monkey (OWM) species. Despite their known wide distribution in primates, nothing is currently known about the occurrence, frequency, and genetic diversity of enteroviruses infecting apes. To investigate this, 27 chimpanzee and 27 gorilla fecal samples collected from undisturbed jungle areas with minimal human contact in Cameroon were screened for EVs. Four chimpanzee samples were positive, but none of the gorilla samples were positive. Genetic characterization of the VP1, VP4, and partial VP2 genes, the 5 untranslated region, and partial 3Dpol sequences enabled chimpanzee-derived EVs to be identified as (i) the species A type, EV76, (ii) a new species D type assigned as EV111, along with a human isolate from the Democratic Republic of Congo previously described by the International Committee on the Taxonomy of Viruses, and (iii) a new species B type (assigned as EV110) most closely related to, although a distinct type from, the SA5 isolate recovered from a vervet monkey. The identification of EVs infecting chimpanzees related to those circulating in human and OWM populations provides evidence for cross-species transmission of EVs between primates. However, the direction of transfer and the existence of primate sources of zoonotic enterovirus infections in humans require further investigation of population exposure and more extensive characterization of EVs circulating in wild ape populations.

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Detection and Genetic Characterization of Enteroviruses Circulating among Wild Populations of Chimpanzees in Cameroon: Relationship with Human and Simian Enteroviruses

Harvala

Sharp

Ngole

et al. 2011

J Virol

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“…Simian virus 5 (SV5) was originally isolated from rhesus and cynomolgus monkey kidney cell cultures and was therefore presumed to be of simian origin (Hull et al, 1956). However, there have also been a number of reports of the isolation of SV5-1ike viruses from canine sources and accounts of isolation from human tissues (for review, see Hsiung, 1972).…”

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confidence: 99%

Does Simian Virus 5 Infect Humans?

Goswami¹,

Lange

Mitchell

et al. 1984

Journal of General Virology

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SUMMARYSimian virus 5 (SV5) isolates derived after co-cultivation of human bone marrow aspirates of multiple sclerosis (MS) patients were shown by immunoprecipitation, cross-neutralization and haemagglutination inhibition techniques to be similar antigenically but not identical to the prototype strain. Analyses of human sera (MS and control) showed that about 20 ~ contained neutralizing antibodies to SV5 and immunoprecipitated the specific SV5 HN polypeptide. A competition assay using a specific SV5 monoclonal antibody confirmed that a human serum containing such neutralizing activity also blocked a specific SV5 epitope whereas another human serum with demonstrable antibodies to the related human parainfluenza virus type 2 did not block this epitope. These tests therefore suggested that SV5 can infect humans. However, there was no indication, on the basis of these tests, of any aetiological relationship of the SV5 infection to the induction of MS.

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“…The use of nonhuman primates in biomedical research has led to the isolation of many simian viruses (4,5). These viruses were given either consecutive SV (simian virus; for isolates from Asian monkeys) or SA (simian agent; for isolates from African monkeys) numbers (7,10).…”

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confidence: 99%