New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents

Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents

“…Pyrimidine derivatives form a component in a number of useful drugs and are associated with many biological, pharmaceutical and therapeutical activities 18 . Condensed pyrimidine derivatives have been reported as antimicrobial 19 , analgesic 20 , antiviral, anti-inflammatory 21 , anti-HIV 22 , antitubercular 23 , antitumour 24 , antineoplastic 25 , antimalarial 26 , diuretic 27 and antiplatelet agents 28 . Like pyrimidines, carbazole compounds also exhibits diverse biological properties.…”

Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring

“…These compounds showed significant anti-TB activity (MICs down to ≤2 μg/mL). Among all, one compound (57) has shown MIC=0.5-1 μg/mL against Mtb H37Rv [76]. A homologous series of three pyrazolopyrimidine analogues (58a-c) of a hypothetical intermediate in the lumazine synthase-catalyzed reaction and evaluated as lumazine synthase inhibitors.…”

Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives

“…It is known that many 1,3,4-thiadiazoles have biological activities like antibacterial [9], antimycobacterial [10], antimycotic [11], antifungal [12], antidepression [13], analgesic [14] and anti-inflammatory [15]. Nitrogen containing heterocyclic ring such as pyrimidine and its derivatives have been reported as anti-microbial [16], analgesic, anti-viral, anti-inflammatory [17], anti-HIV [18], anti-tubercular [19], anti-tumour [20], anti-neoplastic [21], anti-malarial [22], diuretic [23], cardiovascular [24] agents. Here in, we report a series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives.…”