New solid-phase extraction for an improved high-performance liquid chromatographic procedure for the quantitation of halofantrine and monodesbutylhalofantrine in blood or plasma

Gaillard, Yvan; Prevosto, J. M.; Cheminel, V.; Soares, Olivier; Chaulet, J. F.

doi:10.1016/0378-4347(95)00075-t

Cited by 13 publications

(11 citation statements)

References 21 publications

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“…The sensitivity of the current method is an improvement (3-4 times) on those of other HPLC methods (Gaillard et al, 1995;Kolade et al, 2006). Moreover, it is important to note that relatively large samples sizes (1 mL) were required in these reports whereas only 0.2 mL of plasma is required in the present method.…”

mentioning

confidence: 81%

“…Various methods have been reported for the determination of Hf and Hfm in biological samples, using high-performance liquid chromatography (HPLC) with fluorescence (Gaillard et al, 1995;Camilleri and Thorpe, 1990) and ultraviolet (UV) (Humberstone et al, 1995;Kolade et al, 2006;Onyeji and Aideloje, 1997;Hines et al, 1985;Milton et al, 1988) detection. Limitations of most of the reported methods include poor sensitivity (Hines et al, 1985), complicated solid-phase extraction (Gaillard et al, 1995;Milton et al, 1988), non-commercial availability of internal standard (Humberstone et al, 1995) and requirement of large sample volume (Kolade et al, 2006;Onyeji and Aideloje, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Limitations of most of the reported methods include poor sensitivity (Hines et al, 1985), complicated solid-phase extraction (Gaillard et al, 1995;Milton et al, 1988), non-commercial availability of internal standard (Humberstone et al, 1995) and requirement of large sample volume (Kolade et al, 2006;Onyeji and Aideloje, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Determination of halofantrine and its main metabolite desbutylhalofantrine in rat plasma by high‐performance liquid chromatography with on‐line UV irradiation and peroxyoxalate chemiluminescence detection

Amponsaa-Karikari

Kishikawa

Ohyama

et al. 2008

Biomedical Chromatography

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A sensitive, selective and reliable method has been developed and validated for the determination of halofantrine and its metabolite desbutylhalofantrine in rat plasma using 9,10-diphenylanthracene as an internal standard. The method is based on peroxyoxalate chemiluminescence detection of hydrogen peroxide produced from fused aromatic rings in the structures of halofantrine and desbutylhalofantrine upon UV irradiation. Using spiked rat plasma, good linear relationships were obtained for both halofantrine and desbutylhalofantrine between peak height ratios (vs internal standard) and their corresponding concentrations over a range of 0.01-0.8 microg/mL with correlation coefficients of at least 0.997. The detection limits at signal-to-noise ratio of 3 using 0.2 mL of rat plasma were 1.5 and 1.4 ng/mL for halofantrine and desbutylhalofantrine, respectively. Relative standard deviations (n = 3) intra- and inter-day were between 0.5 and 5.4% for all the studied concentrations. Using this method with simple sample treatment, halofantrine and desbutylhalofantrine in rat plasma could be precisely determined without interference from endogenous substances. The method was successfully applied to the measurement of the time courses of plasma halofantrine concentration after oral administration of the drug (7 mg/kg) to rats.

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mentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Determination of halofantrine and its main metabolite desbutylhalofantrine in rat plasma by high‐performance liquid chromatography with on‐line UV irradiation and peroxyoxalate chemiluminescence detection

Amponsaa-Karikari

Kishikawa

Ohyama

et al. 2008

Biomedical Chromatography

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“…Various methods have been employed for the analysis of halofantrine by titrimetry, spectrophotometry (Kolade et al, 2006;Ahmad and Hridaya, 2002) and halofantrine with its metabolite in biological fluids (Onyeji and Aideloje, 1997;Humberstone et al, 1995;Gaillard et al, 1995;Mberu et al, 1992;Gimenez et al, 1992;Keeratithakul et al, 1991;Milton et al, 1988;Gawienowski et al, 1988;Hines et al, 1985) by high-performance liquid chromatography.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatographic analysis of halofantrine from dosage form and its metal interaction studies

et al. 2010

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The reversed-phase high-performance liquid chromatographic method has been developed for the determination of halofantrine from dosage form in presence of losartan potassium as an internal standard. Separation was performed on a Chrompack hypersil C 18 (150 9 4.6 mm) analytical reversed-phase column. Mobile phase consisted of methanol-water (70:30, v/v) pH was adjusted to 3.2 with 85% orthophosphoric acid. Mobile phase was pumped at a flow rate of 0.5 mL min -1 and UV detection was performed at 248 nm. The method was validated for linearity, precision, accuracy and specificity. The linearity was observed in the concentration range 1.0-50 lg mL -1 with correlation coefficient (r 2 ) of 0.9998. Accuracy was ranged 98-100% with precision less than 1%. The limits of detection (LOD) and (LOQ) were 0.01 and 0.03 lg mL -1 , respectively. This method was applied to study the drug-metal (calcium, magnesium, manganese, cobalt, ferrous, ferric chromium, zinc, nickel, cadmium, iron and copper) interaction studies which were carried out at 37°C. These studies were beneficial to determine the drug in therapeutic concentrations inside human body as well as its complexation with metal ions. The proposed method is rapid, accurate, economical and selective because of its sensitivity and reproducibility.

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“…Several HPLC methods for the determination of Hf and DHf in biological fluids have been reported [6][7][8][9][10][11][12][13]. However, most methods require solid-phase extraction procedures [7][8][9][10], which require additional equipment and the supply of solidphase extraction cartridges.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography

Kolade

Babalola

Scriba

2006

Journal of Pharmaceutical and Biomedical Analysis

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New solid-phase extraction for an improved high-performance liquid chromatographic procedure for the quantitation of halofantrine and monodesbutylhalofantrine in blood or plasma

Cited by 13 publications

References 21 publications

Determination of halofantrine and its main metabolite desbutylhalofantrine in rat plasma by high‐performance liquid chromatography with on‐line UV irradiation and peroxyoxalate chemiluminescence detection

Determination of halofantrine and its main metabolite desbutylhalofantrine in rat plasma by high‐performance liquid chromatography with on‐line UV irradiation and peroxyoxalate chemiluminescence detection

Liquid chromatographic analysis of halofantrine from dosage form and its metal interaction studies

Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography

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