New resveratrol micelle formulation for ocular delivery: characterization and in vitro/in vivo evaluation

Abstract

SI MATERIALS AND METHODS 1 Chemical Reagents, cells, and animalsPolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus ® , designated as Sol) was donated by the BASF Corporation (Shanghai, China). Resveratrol (Res) was provided by Dalian Meilun Biology Technology Co., Ltd. (Liaoning, China).Coumarin 6 (Cou-6) and benzalkonium chloride (BAC) were purchased from

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

“…In addition, the corneal permeability of micelles at 30 min was more than 4 times that of free drugs, and it also showed resveratrol. 57 The Sol-Res micelle had a strong HCE cell uptake effect at 60 min. The inhibitory effect of micelles on inflammatory mediators was verified by a rabbit corneal wound model, and the results showed complete healing at 72 h. The excellent anti-inflammatory effect of these micelles may be related to the long-term existence of micelles in the circulatory system and their aggregation in the inflammatory region, which was illustrated in research conducted by Mehra and co-workers.…”

Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

“…According to in vivo experiments, the level of expression of the inflammatory markers IL-6, TNFα and COX-1 decreased significantly after treatment of the inflamed cornea with micelle ophthalmic solution containing resveratrol. At the same time, the mRNAs corresponding to the antioxidant enzymes SOD and haem oxygenase 1 (HO-1) and the protein SIRT1 increased significantly under the same experimental conditions [ 199 ].…”

Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

“…Polymeric micelles can therefore be considered as one of the most promising techniques in ocular drug delivery for the treatment of both anterior and posterior segment of eye diseases such as DES, AMD, DR, glaucoma ( Alviset et al, 2022 ), endophthalmitis, retinitis and corneal or conjunctival squamous cell carcinoma ( Madni et al, 2017 ). Li et al (2020a) evaluated a Soluplus micelle of resveratrol (SOL-RES) for corneal wound healing. In a separate study of cellular uptake and corneal permeation, coumarin-6 loaded within nanomicelles.…”

“…In a separate study of cellular uptake and corneal permeation, coumarin-6 loaded within nanomicelles. The irritation test and histopathological observation of rabbit corneas were evaluated 24 h after eye drops instillation and results indicated good ocular tolerance and no eye irritation ( Li et al, 2020a ).…”