Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

Abstract

Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low stability and bioavailability. To overcome this problem, researchers started to design and create different delivery systems that could improve the delivery amount of Rv. Therefore, this review aims to shed light on the proper and efficient techniques to isolate, purify and quantify the Rv molecule, and how this therapeutic molecule can be a part of a delivery system. The Rv great impact on aspects regarding its stability, bioavailability and absorption are also debated here, based on the existent literature on in vitro and in vivo human and animal studies. Moreover, after its absorption the Rv influence at the molecular level in ocular pathologies is described. In addition, the present review summarizes the available literature about Rv, hoping that Rv will gain more attention to investigate its unexplored side.

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

“…When it comes to the extraction of stilbenes, as for other polyphenolic compounds, alcoholic solvents, such as methanol, ethanol, isopropyl alcohol, or their mixture with water, are the most frequently used ones (Pop et al, 2022;Teka et al, 2022;D. G. Wang et al, 2013).…”

“…G. Wang et al, 2013). Ethyl acetate and acetone are other common solvents used for the extraction of these compounds from plant sources (Pop et al, 2022). As for TSG, due to its strong chemical polarity, it is easily extracted using water (J.…”

“…Several analytical techniques have been applied to the qualitative and quantitative analysis of stilbenes in dietary products. The most common one is high-performance liquid chromatography (HPLC) coupled with different detectors (Pop et al, 2022;Teka et al, 2022).…”

“…The fluorescence of stilbenes is the property that is also exploited for their analysis. In this perspective, two different techniques have been validated to analyze resveratrol in dietary supplements: constant wavelength synchronous spectrofluorimetry (CWSFS) and HPLC with fluorescence detector (FLD) (Pop et al, 2022). Stilbenes in several natural sources have also been analyzed using gas chromatography (GC) coupled with MS, though to a lesser extent and prior derivatization of compounds to enhance their volatility (Viñas et al, 2009).…”

“…When it comes to the extraction of stilbenes, as for other polyphenolic compounds, alcoholic solvents, such as methanol, ethanol, isopropyl alcohol, or their mixture with water, are the most frequently used ones (Pop et al, 2022; Teka et al, 2022; D. G. Wang et al, 2013). Ethyl acetate and acetone are other common solvents used for the extraction of these compounds from plant sources (Pop et al, 2022). As for TSG, due to its strong chemical polarity, it is easily extracted using water (J. Qian et al, 2020).…”