New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer

Alban, Luisa; Monteiro, Wesley F.; Diz, Fernando Mendonça; Miranda, Gabriela Messias; Scheid, Carolina Majolo; Zotti, Eduardo Rosa; Morrone, Fernanda Bueno; Ligabue, Rosane Angélica

doi:10.1016/j.msec.2020.110662

Cited by 30 publications

(18 citation statements)

References 86 publications

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“…FTIR spectroscopic investigation of the as-synthesized catalysts ( Figure 1 c) show the strong absorption band at 3600 cm −1 corresponding to the stretching vibrations of the OH groups from the Ti–OH bonds of the trititanate structure [ 39 , 40 ]. Moreover, these OH groups can be attributed to either physically adsorbed water or the extra framework hydroxides such as α-CrOOH, α-CoOOH, NiOOH, α-AlOOH and Pt species, in agreement with XRD and Raman results.…”

Section: Resultsmentioning

confidence: 99%

Effects of the Incorporation of Distinct Cations in Titanate Nanotubes on the Catalytic Activity in NOx Conversion

et al. 2021

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Effects of the incorporation of Cr, Ni, Co, Ag, Al, Ni and Pt cations in titanate nanotubes (NTs) were examined on the NOx conversion. The structural and morphological characterizations evidenced that the ion-exchange reaction of Cr, Co, Ni and Al ions with the NTs produced catalysts with metals included in the interlayer regions of the trititanate NTs whereas an assembly of Ag and Pt nanoparticles were either on the nanotubes surface or inner diameters through an impregnation process. Understanding the role of the different metal cations intercalated or supported on the nanotubes, the optimal selective catalytic reduction of NOx by CO reaction (SCR) conditions was investigated by carrying out variations in the reaction temperature, SO2 and H2O poisoning and long-term stability runs. Pt nanoparticles on the NTs exhibited superior activity compared to the Cr, Co and Al intercalated in the nanotubes and even to the Ag and Ni counterparts. Resistance against SO2 poisoning was low on NiNT due to the trititanate phase transformation into TiO2 and also to sulfur deposits on Ni sites. However, the interaction between Pt2+ from PtOx and Ti4+ in the NTs favored the adsorption of both NOx and CO enhancing the catalytic performance.

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Section: Resultsmentioning

confidence: 99%

Effects of the Incorporation of Distinct Cations in Titanate Nanotubes on the Catalytic Activity in NOx Conversion

et al. 2021

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“…In vivo study showed that maximum quercetin delivery was observed after 24 h, and its release was controlled by Zn. Moreover, both NaTNTQc and ZnTNTQc nanostructures decreased the viability of BC cells after 48 h of exposure [104].…”

Section: Therapeutic Potential Of Quercetin In Bcmentioning

confidence: 92%

The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

Wigner

Bijak

Saluk‐Bijak

2021

IJMS

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Bladder cancer (BC) is the second most common genitourinary cancer. In 2018, 550,000 people in the world were diagnosed with BC, and the number of new cases continues to rise. BC is also characterized by high recurrence risk, despite therapies. Although in the last few years, the range of BC therapy has considerably widened, it is associated with severe side effects and the development of drug resistance, which is hampering treatment success. Thus, patients are increasingly choosing products of natural origin as an alternative or complementary therapeutic options. Therefore, in this article, we aim to elucidate, using the available literature, the role of natural substances such as curcumin, sulforaphane, resveratrol, quercetin, 6-gingerol, delphinidin, epigallocatechin-3-gallate and gossypol in the BC treatment. Numerous clinical and preclinical studies point to their role in the modulation of the signaling pathways, such as cell proliferation, cell survival, apoptosis and cell death.

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“…A recent study documented that a quercetin-zinc complex ≥12.5 μM decreased viability, cell migration and invasiveness and increased apoptosis in BC cells, with a mechanism involving down-regulation of pAkt/Akt and MT1-MMP protein expression [115]. In addition, quercetin incorporated in sodium or zinc titanate nanotubes (both at 25-200 µg/mL) decreased viability of BC cells and their ability to form clones, thus suggesting that these nanostructures can interfere with cancer cell proliferation [116].…”

Section: Bladder Cancermentioning

confidence: 99%

The molecular basis of the anticancer properties of quercetin

Adorisio¹,

Argentieri²,

Avato³

et al. 2021

Pharm Adv

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Quercetin is a major constituent of various dietary products, which is increasingly being investigated as a therapeutic option in the oncological field. It has attracted extensive interest due to its ability of interacting with different molecular targets and evoking a broad spectrum of chemopreventive and anticancer activities. In this review, we have tried to present and critically discuss its potential against an extensive range of cancers including lung, ovarian, prostate, breast, colorectal, bladder cancers. We also highlighted studies that combined quercetin with standard anticancer drugs and delivered it via novel techniques and included a detailed description of its proposed mechanism(s) of action, and pharmacokinetic and safety profile. KeywordsQuercetin, cancer, bioavailability, mechanisms of action, in vivo and in vitro studies Funding Nothing to declare.

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New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer

Cited by 30 publications

References 86 publications

Effects of the Incorporation of Distinct Cations in Titanate Nanotubes on the Catalytic Activity in NOx Conversion

Effects of the Incorporation of Distinct Cations in Titanate Nanotubes on the Catalytic Activity in NOx Conversion

The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

The molecular basis of the anticancer properties of quercetin

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