New Protocol for Determination of Rifampicine by Adsorptive Stripping Voltammetry

Abstract

For determinations of organic compounds by adsorptive stripping voltammetry till now the same material of the electrode has been used for the accumulation and stripping steps. This paper describes a new protocol for extending the range of organic compounds, which can be determined by adsorptive stripping voltammetry. In the proposed procedure the accumulation step was performed on the electrode modified by a lead film, which assures adsorption of the studied species on the modified electrode and then the stripping step of the accumulated substance was performed on the support of the lead film electrode. As an example rifampicine was accumulated by adsorption at the lead film electrode while in the stripping step lead film and then the accumulated rifampicine were oxidized at a glassy carbon electrode. Using an acetate buffer as a supporting electrolyte a calibration graph for rifampicine in the range from 2.5 Â 10 À10 to 1 Â 10 À8 mol L À1 was obtained. The detection limit for rifampicine following 60 s accumulation time was equal to 9 Â 10 À11 mol L À1 . The obtained detection limit was comparable or lower than reported previously for other stripping voltammetric procedures. The proposed procedure was applied to rifampicine determination in pharmaceutical preparation.

Microscopic and electrochemical characterization of lead film electrode applied in adsorptive stripping analysis

“…So far, the lead film electrode has only been applied for analytical purposes, i.e. for the adsorptive stripping determination of selected metal ions and some organic substances [29][30][31][32]35,36]. In the vast majority of the above quoted works, the ammonia buffer was used as a main component of a supporting electrolyte.…”

Voltammetric/amperometric screening of compounds of pharmacological interest

“…Explicit application for determination of drugs in human urine (El-Maali 2000, Garcia-Fernandez et al 2000, Fernandez Torres et al 2002, Shih et al 2002, Hilali et al 2003, Morais et al 2003, Reddy and Sreedhar 2003, Razak 2004, Ensafi and Hajian 2008a,b, Daneshgar et al 2009a,b, Muralidharan et al 2009, Tyszczuk and Korolczuk 2009a,b, Behpour et al 2010, Ensafi et al 2011, Zayed 2011, Gopu et al 2012, Khaskheli et al 2012, Gupta et al 2013a,b, Lakshmi and Vedhi 2013, Švorc et al 2013) and human serum , Sreedhar et al 2001, Altinoz and Nemutlu 2002, El-Hefnawy et al 2003, Coruh and Ozkan 2006, Wang et al 2006, Altun et al 2007, Beltagi et al 2007aEl-Desoky 2009, Alarfaj 2013, Arvand and Gholizadeh 2013 are numerous. In contrast, few reports are addressed to determinations in cerebrospinal fluid (Jimenez Palacios et al 2003), bovine muscle and serum (Ammida et al 2004, Barbosa et al 2006, and milk (Billova et al 2003).…”

Electrochemical Determination of Rifampicin Based on Its Oxidation UsingMultiwalled Carbon Nanotubes Modified Glassy Carbon Electrode

“…u n c o r r e c t e d p r o o f spectroscopy, 12 NMR spectroscopy, 13 and UV-Vis spectrophotometry. 14 Few electrochemical studies of RIF have also been found studied both in the direction of oxidation using some unmodified 15,16 and modified electrodes [17][18][19][20][21] and in the direction of reduction. 22,23 The older studies of RIF were based on the electrochemical reduction of RIF using mercury drop electrode by differential pulse polarography 22 and differential pulse adsorptive stripping voltammetry (DPAdSV) 23 .…”