New progress and prospects: The application of nanogel in drug delivery

Zhou, Hui; Zhai, Yingjie; Wang, Juan; Zhai, Guangxi

doi:10.1016/j.msec.2015.11.041

Cited by 272 publications

(150 citation statements)

References 88 publications

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“…[8] Addition of other hydrophilic monomer enhances complexation efficiency of drugs with cyclodextrin and reduces production cost. [17] Cyclodextrin-based nanogels confer unique technological advantages regarding inclusion complex formation and hydrophilicity enhancement of polymer matrix. [9,10] Hydrogels are three-dimensional matrix of physical or chemical cross-linked biocompatible polymers that take up water.…”

Section: Introductionmentioning

confidence: 99%

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

2017

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The purpose of this study was to develop and characterize hydroxypropyl-βcyclodextrin (HPβCD) hybrid nanogels for solubility enhancement of lipophilic drug, dexibuprofen. HPβCD hybrid nanogels were designed by chemical crosslinking of hydroxypropyl-β-cyclodextrin with 2-acrylamido-2-methyl propane sulfonic acid (AMPS) via free radical polymerization. Loading efficiency, solubilization, zetasizer, FESEM Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), powder X-ray diffraction (PXRD), and in vitro drug release analysis were performed for characterization of hybrid nanogels. Efficient solubilization of dexibuprofen has been observed by HPβCD hybrid nanogels. FTIR, TGA, and DSC studies confirmed the formation of new hybrid nanogels and complexation of dexibuprofen with nanogels. XRD analysis revealed loss of dexibuprofen crystallinity in hybrid nanogels. Highly porous and amorphous nanogels showed a significant dexibuprofen release in aqueous medium. In toxicity studies, no significant changes in behavioral, physiological, biochemical, or histopathological parameters of animals endorsed that developed formulations are nontoxic and biocompatible. K E Y W O R D Samorphous, differential scanning calorimetry, drug delivery systems, Fourier transform infrared, hostguest systems, hybrid nanogels, hydroxypropyl-β-cyclodextrin, nanotechnology, radical polymerization, thermal gravimetric analysis, toxicity studies

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Section: Introductionmentioning

confidence: 99%

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

2017

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“…If the conjugate is designed correctly, factors such as the conjugate concentration, solvent choice, titration or mixing rate, and agitation play an important role in determining the size and shape of the nanostructures8. Now, many polymer-drug conjugates have been reported to self-assemble forming nanomedicines, including micelles9 or nanogels10. However, since the molecular weight of the polymer is higher than that of the anticancer drug, the drug occupancy rate in these polymer-drug conjugates is not very high, such as polyethylene glycol-paclitaxel (PEG-PTX) conjugate (drug occupancy rate 6.0%)11, hydroxypropyl methacrylate-paclitaxel (HPMA-PTX) conjugate (drug occupancy rate 7.3%)12 and cholesteryl-hyaluronic acid-salinomycin (CHA-SAL) conjugate (drug occupancy rate 21.6%)13.…”

mentioning

confidence: 99%

A self-assembling nanomedicine of conjugated linoleic acid-paclitaxel conjugate (CLA-PTX) with higher drug loading and carrier-free characteristic

Zhong

Yao

Zhang

et al. 2016

Sci Rep

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The main objective of this study was to demonstrate the proof-of-principle for the hypothesis that conjugated linoleic acid-paclitaxel conjugate (CLA-PTX), a novel fatty acid modified anti-cancer drug conjugate, could self-assemble forming nanoparticles. The results indicated that a novel self-assembling nanomedicine, CLA-PTX@PEG NPs (about 105 nm), with Cremophor EL (CrEL)-free and organic solvent-free characteristics, was prepared by a simple precipitation method. Being the ratio of CLA-PTX:DSPE-PEG was only 1:0.1 (w/w), the higher drug loading CLA-PTX@PEG NPs (about 90%) possessed carrier-free characteristic. The stability results indicated that CLA-PTX@PEG NPs could be stored for at least 9 months. The safety of CLA-PTX@PEG NPs was demonstrated by the MTD results. The anti-tumor activity and cellular uptake were also confirmed in the in vitro experiments. The lower crystallinity, polarity and solubility of CLA-PTX compared with that of paclitaxel (PTX) might be the possible reason for CLA-PTX self-assembling forming nanoparticles, indicating a relationship between PTX modification and nanoparticles self-assembly. Overall, the data presented here confirm that this drug self-delivery strategy based on self-assembly of a CLA-PTX conjugate may offer a new way to prepare nanomedicine products for cancer therapy involving the relationship between anticancer drug modification and self-assembly into nanoparticles.

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“…Nanogel is an advanced formulation of nano-sized hydrogel particles. Nanogel possesses advantage above its original macroscopic hydrogel that it can be injected in the circulation directly to target tissues and can better deliver their payloads for both local and systemic applications (15). It has been reported that nanogels not only protect the drugs from degradation and elimination but also participate actively in the delivery process due to their characteristic properties like adhesive, stimuli-responsive behaviour, softness and swelling to help achieve a controlled response at the target tissues (16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%