New principles from seeds of Nigella sativa

Abstract

A new triterpene saponin and known steroidal glucoside were isolated from the alcohol extract, and a new cycloartenol from n-hexane extract of seeds of Nigella sativa L. and were identified as 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl]-11-methoxy-16,23-dihydroxy-28-methylolean-12-enoate (1), stigma-5,22-dien-3-beta-D-glucopyranoside (2) and cycloart-23-methyl-7,20, 22-triene-3beta,25-diol (3), respectively. They were characterised on the basis of spectral analysis and comparison with literature data. The hexane and alcohol extract of the seeds showed antimicrobial activity. The antioxidant activity of hexane extract is also described.

A review on therapeutic potential of Nigella sativa: A miracle herb

“…The antioxidant effects of curcumin, NSO and valproate on the levels of malondialdehyde, nitric oxide, reduced glutathione and the activities of CAT, Na⁺, K⁺-ATPase and acetylcholinesterase in the hippocampus of pilocarpineinduced animal model of epilepsy was evaluated and left for 22 NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels. Results indicated the anticonvulsant and potent antioxidant effects of curcumin and NSO in reducing oxidative stress, excitability and the induction of seizures in epileptic animals and improving some of the adverse effects of antiepileptic drugs [109] .…”

“…Examples of various other reported chemical components includes nigellone,avenasterol-5-ene, avenasterol-7 -ene, campesterol, cholesterol, citrostadienol, cycloeucalenol, ,gramisterol, lophenol, obtusifoliol, stigmastanol, stigmasterol-7-ene, β-amyrin, butyrospermol, cycloartenol, 24- gluco-pyranosyl] hederagenin, volatile oil (0.5-1.6%), fatty oil (35.6-41.6%), oleic acid, esters of unsaturated fatty acids with C15 and higher terpenoids, esters of dehydrostearic and linoleic acid, aliphatic alcohol, β-unsaturated hydroxy ketone, hederagenin glycoside, melanthin, melanthigenin, bitter principle, tannin, resin, protein, reducing sugar, glycosidal saponin, 3 23-dihydroxy-28-methy-lolean-12-enoate,stigma-5, 22-dien-3-β-D-gluco-pyranoside, cycloart-23-methyl-7, 20, 22-triene-3β, 25-diol, nigellidine-4-O-sulfite, N. mines A3, A4, A5, C, N. mines A1, A2, B1, and B2 [18][19][20][21][22] .…”

Sources and possible mechanisms of action of important phytoconstituents with cardiovascular properties

“…It has been used traditionally as a medicinal plant since 2000 years (Salem et al, 2005). Its seeds consist of eight essential amino acids and bioactive alkaloids as nigellamine and nigelline (Mehta et al, 2009) while its volatile oil is composed of thymoquinone (2.1%) (Tahraoui et al, 2007), cymene P (4.5%), thujene α (7.8%), pinene β (2.9%), carvacrol (2.2%), terpinene α (1.7%), limonene (2.9%), campholenol α (9.8%) and terpinene G (13%). It is being used to cure a number of diseases including asthma, obesity, dyslipidemia, hypertension (Qidwai et al, 2009), cough, bronchitis, headache, eczema, dizziness, gastrointestinal disturbances, atherosclerosis, fever and influenza.…”

Effect of Nigella sativa L. seed extract on cisplatin-induced delay in gastric emptying in Sprague-Dawley rats

“…The seed of Nigella sativa L. (NS) known as black cumin is a promising medicinal plant component reported to have potent antioxidant effects, and many therapeutic effects of the NS seed have been documented, including antiviral (Barakat et al 2013), anti-schistosomiasis (el Shenawy et al 2008, anti-inflammatory (Marsik et al 2005;Majdalawieh & Fayyad 2015), antimicrobial (Mehta et al 2009;Sarwar & Latif 2015), immunomodulatory activities (Tekeoglu et al 2007;Majdalawieh & Fayyad 2015), anti-tumour properties (Linjawi et al 2015) and inhibit polymorphonuclear leukocytes functions (Kacema & Meraihi 2009). Also, it is been found to attenuate toxic side effects like nephrotoxicity, hepatoxicity induced by several chemotherapeutic agents (Yaman & Balikci 2010;Kushwah et al 2014).…”