A review on therapeutic potential of Nigella sativa: A miracle herb

Cytotoxicity of Nigella Sativa Seed Oil and Extract Against Human Lung Cancer Cell Line

“…Nigella sativa (N sativa) of Ranunculaceae family is widely used medicinal plant throughout the world. It is very popular in various traditional systems of medicine like Unani and Tibb, Ayurveda and Siddha, and the seeds and oil of N sativa have a long history of folklore usage in various systems of medicines and food (Ahmad et al, 2013).…”

Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-κB Transcription Factors and the Induction of Cytoprotective Genes

“…The discovery and use of active medicinal compounds from herbal/natural sources have provided alternative remedies for CRC treatment (Aggarwal et al, 2009). Among natural herbs, N. sativa has been used for medicinal purposes as a natural remedy for a number of disorders including cancerous growths (Ahmad et al, 2013). It has been found that the most active component in N. sativa, is a phenolic compound, thymoquinone (Ahmad et al, 2013).…”

“…Among natural herbs, N. sativa has been used for medicinal purposes as a natural remedy for a number of disorders including cancerous growths (Ahmad et al, 2013). It has been found that the most active component in N. sativa, is a phenolic compound, thymoquinone (Ahmad et al, 2013). Despite thymoquinone's generally low toxicity, it exhibits weak antitumor effects in numerous cancer-cell studies and animal models (Badary et al, 2001;Badary et al, 199;Gali-Muhtasib et al, 2006;.…”

“…Most importantly, numerous studies have shown that the seeds and oil of this herb are characterized by a very low degree of toxicity (Ali and Blunden, 2003). Several classes of compounds have been isolated from the seeds of N. sativa, such as alkaloids, flavonol triglycosides, saponins and an isobenzofuranone derivative (Ahmad et al, 2013). Among these active compounds, much of the biological activities of the seeds have been attributed to thymoquinone, the major component of the essential oil (Banerjee et al, 2010).…”

Protective Effect of Nigella Sativa (Black Caraway (Oil on Oral Dichlorvos Induced Hematological, Renal and Nonspecific Immune System Toxicity in Wistar Rats

“…Nigella sativa Linn. (Ranunculaceae) is a medicinal plant also known as black caraway, black cumin, Habbatul Barakah or and Kalonji seed, is widely used in the treatment of various ailments such as bronchial asthma, cough, diarrhoea, abdominal pain, and dyslipidemia [9]. N. sativa oil (NSO] exhibits pharmacological activities including the ability to act as a chelating agent [10], antioxidant and antiinflammatory [11], immunomodulatory and antitumor substances [12].…”