New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

Чаусов, Д. Н.; Burmistrov, Dmitriy; Kurilov, Alexander D.; Bunkin, N. F.; Astashev, Maxim E.; Simakin, Alexander V.; Vedunova, Maria; Gudkov, Sergey V.

doi:10.3390/ma14216281

Cited by 13 publications

(18 citation statements)

References 67 publications

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“…The resulting NPs were transferred into PLGA polymer using a previously developed low-temperature technology [47]. The composite PLGA/Ag 2 O NPs had visually smooth surfaces.…”

Section: Resultsmentioning

confidence: 99%

“…The ratio of atoms Ag/O = 1.94; thus, it can be assumed that the nanoparticles are predominantly composed of Ag2O. The resulting NPs were transferred into PLGA polymer using a previously developed low-temperature technology [47]. The composite PLGA/Ag2O NPs had visually smooth surfaces.…”

Section: Resultsmentioning

confidence: 99%

“…The PLGA-based composite with silver oxide NPS was synthesized by the low-temperature technology developed by us earlier [47]. Production of plates from composite material.…”

Section: Composite Fabrication Production Of Plates From Composite Material and Rheological Propertiesmentioning

confidence: 99%

“…This method makes it possible to fairly finely control the size of the resulting NPs due to the synthesis conditions (radiation parameters and the solvent used) [43][44][45][46]. Additional advantages of laser ablation are its high speed and low cost of synthesis [47]. The unusual physicochemical properties of the nanocomposite have been investigated, its bacteriostatic activity has been determined, and its biocompatibility has been studied.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

et al. 2021

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A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 108 nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans.

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“…The resulting NPs were transferred into PLGA polymer using a previously developed low-temperature technology [47]. The composite PLGA/Ag 2 O NPs had visually smooth surfaces.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The PLGA-based composite with silver oxide NPS was synthesized by the low-temperature technology developed by us earlier [47]. Production of plates from composite material.…”

Section: Composite Fabrication Production Of Plates From Composite Material and Rheological Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

et al. 2021

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“…There is a wide range of polymers used as matrices for composites. These include compounds such as chitosan [ 16 , 17 ], gelatin [ 18 ], polyvinyl alcohol (PVA) [ 19 , 20 , 21 ], polylactate (PLA) [ 22 ], polypropylene [ 15 ], borosiloxane [ 23 , 24 ], and PLGA (poly (lactic-co-glycolic acid)) [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Bacteriostatic and Cytotoxic Properties of Composite Material Based on ZnO Nanoparticles in PLGA Obtained by Low Temperature Method

et al. 2021

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A low-temperature technology was developed for producing a nanocomposite based on poly (lactic-co-glycolic acid) and zinc oxide nanoparticles (ZnO-NPs), synthesized by laser ablation. Nanocomposites were created containing 0.001, 0.01, and 0.1% of zinc oxide nanoparticles with rod-like morphology and a size of 40–70 nm. The surface of the films from the obtained nanomaterial was uniform, without significant defects. Clustering of ZnO-NPs in the PLGA matrix was noted, which increased with an increase in the concentration of the dopant in the polymer. The resulting nanomaterial was capable of generating reactive oxygen species (ROS), such as hydrogen peroxide and hydroxyl radicals. The rate of ROS generation increased with an increase in the concentration of the dopant. It was shown that the synthesized nanocomposite promotes the formation of long-lived reactive protein species, and is also the reason for the appearance of a key biomarker of oxidative stress, 8-oxoguanine, in DNA. The intensity of the process increased with an increase in the concentration of nanoparticles in the matrix. It was found that the nanocomposite exhibits significant bacteriostatic properties, the severity of which depends on the concentration of nanoparticles. In particular, on the surface of the PLGA–ZnO-NPs composite film containing 0.001% nanoparticles, the number of bacterial cells was 50% lower than that of pure PLGA. The surface of the composite is non-toxic to eukaryotic cells and does not interfere with their adhesion, growth, and division. Due to its low cytotoxicity and bacteriostatic properties, this nanocomposite can be used as coatings for packaging in the food industry, additives for textiles, and also as a material for biomedicine.

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Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

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et al. 2023

ACS Appl. Nano Mater.

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ZnO nanostructures (ZnO NSs) are able to provide significant antimicrobial activity, ensuring high biocompatibility, good chemical stability, and low toxicity. Such versatility has led to great success of this nanomaterial for antibacterial, antifungal, and, more recently, antiviral applications. However, methods for the preparation of ZnO NSs must be properly selected for their end use. Moreover, ZnO NSs can also be cytotoxic to some extent. In this context, this review emphasizes some aspects relevant to the preparation as well as to the antimicrobial use of ZnO NSs. In particular, a brief overview of the sol–gel, hydrothermal, biogenic, and electrochemical approaches proposed for their synthesis is presented, highlighting advantages/drawbacks of each route in terms of scalability, simplicity, and efficacy. Next, the application of ZnO NSs in several fields is reported. This is followed by a discussion of the antimicrobial role of ZnO NSs, where antimicrobial mechanisms of action, possible cell resistance, and cytotoxicity of ZnO NSs are highlighted. We also discuss the role of ZnO NSs against different biothreats, such as bacteria and viruses. The future of such nanomaterials in this application field is addressed in the final part.

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New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

Cited by 13 publications

References 67 publications

A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

Bacteriostatic and Cytotoxic Properties of Composite Material Based on ZnO Nanoparticles in PLGA Obtained by Low Temperature Method

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

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