New onset squamous cell carcinoma in previous split-thickness skin graft donor site

Noori, Vincent J.; Trehan, Kanika; Savetamal, Alisa; Carter, Damien

doi:10.1016/j.ijsu.2018.01.047

Cited by 9 publications

(14 citation statements)

References 12 publications

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“…11 In the setting of acute burns, a similar setting is provided for cancer cells to develop; evidence suggests that prolonged and repeated epithelization, in conjunction with immunosuppression, makes epidermal cells highly susceptible to carcinogenesis. 10 This rationale is potentially applicable to our patient. Despite the absence of malignancy or burn wounds, our patient had large sites of chronic inflammation that undoubtedly created an environment that could support growth of cancerous cells.…”

Section: Discussionmentioning

confidence: 86%

“…6 Other case reports describe patients who developed SCC at the skin graft donor sites who had undergone reconstruction after burns. 10 Of 3 patients with donor site SCC after skin grafts for burns were completed, 1 patient developed numerous nodules both at the donor site and the burn sites. Our case is one of the few reported occurrences in a patient without evidence of skin cancer or acute burns at time of reconstruction.…”

Section: Discussionmentioning

confidence: 98%

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Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Thomas

Rezzadeh

Rossi

et al. 2021

Plastic Surgery Case Studies

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Introduction: Skin graft reconstruction is a common method of providing wound coverage. Rarely, skin grafting can be associated with the development of squamous cell carcinoma (SCC) in the graft donor site. Case Report: The patient is a 72-year old male with a 15-year history of bilateral hip wounds. He underwent a multitude of treatments previously with failed reconstructive efforts. After presenting to us, he underwent multiple debridements and eventual skin grafting. Within 4 weeks of the final skin graft, a mass developed at the skin graft donor site at the right thigh. Excisional biopsy returned a well differentiated keratinizing SCC. Discussion/Conclusion: This case demonstrates the acute presentation of SCC in a patient following a skin graft without known risk factors. The purpose of this unique case report is to highlight a very rare occurrence of SCC at a skin graft donor site.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 98%

Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Thomas

Rezzadeh

Rossi

et al. 2021

Plastic Surgery Case Studies

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show abstract

“…However, MU can also occur in multiple other parts of the body, including the neck, elbow, scalp, calvarial bones, dura mater, brain, breast skin, nose and other sites (16)(17)(18)(19)(20)(21). The pathological types of MU include squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sarcoma, squamous basal cell carcinoma, squamous cell melanoma and other neoplasms (10,22,23). Among these, squamous cell carcinoma is the most common pathological type of MU (10).…”

Section: Discussionmentioning

confidence: 99%

Marjolin's ulcer: A case report and literature review

2020

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There is currently no agreed standard for the definition, classification, etiology, pathological type, location, treatment and prognosis of Marjolin's ulcer (MU). The present study report a case of a 50-year-old male with inguinal lymph node and bone metastases from an MU on a burn scar on the left lower extremity. The patient carried this scar since he was 1 year old and had a chronic scar ulcer ever since. A histopathological examination of the inguinal lymph nodes and the ulcer demonstrated well-differentiated squamous cell carcinoma. Extensive resection was performed; however, the tumor eventually led to bone metastasis in the tibia. A more thorough second surgical resection that included the regional lymph nodes was more effective as the tumor did not recur. The present case report is complemented by presenting a review of the relevant literature, with an aim of aiding in the development of a preliminary clinical path for MU.

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“…SCC has previously been described to occur in various situations, some of which include traumatic scar lesions, skin graft donor sites, burn scars, and osteomyelitis [6], [7], [8], [9]. KA typically presents as a rapidly growing, pink-skin-colored nodular growth with a central keratin plug.…”

Section: Discussionmentioning

confidence: 99%

Incisional squamous cell carcinoma after total knee arthroplasty

Hess

Rudloff

2019

Arthroplasty Today

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With the rising number of total knee arthroplasties being performed annually, the number of complications associated with this procedure will also continue to rise. The most common reasons for revision include infection, instability, and aseptic loosening. Fortunately, wound complications are rare, and in this case report, we describe the development of a well-differentiated squamous cell carcinoma, keratoacanthomatous type, within the surgical incision of a total knee arthroplasty several months after the index procedure.

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New onset squamous cell carcinoma in previous split-thickness skin graft donor site

Cited by 9 publications

References 12 publications

Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Marjolin's ulcer: A case report and literature review

Incisional squamous cell carcinoma after total knee arthroplasty

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