New‐onset cutaneous kaposi’s sarcoma following SARS‐CoV‐2 infection

Magri, Francesca; Giordano, Stefania; Latini, Alessandra; Mellai, Marta

doi:10.1111/jocd.14549

Cited by 9 publications

(8 citation statements)

References 15 publications

(38 reference statements)

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“…Undetectable viremia from an initial molecular testing followed by the detection of HHV-8 DNA in a subsequent testing [ 71 ] or seropositive for HHV-8 antibodies (not specified) following a complete recovery from COVID-19 [ 52 ]…”

Section: Resultsmentioning

confidence: 99%

Viral reactivations and co-infections in COVID-19 patients: a systematic review

et al. 2023

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Background Viral reactivations and co-infections have been reported among COVID-19 patients. However, studies on the clinical outcomes of different viral reactivations and co-infections are currently in limit. Thus, the primary purpose of this review is to perform an overarching investigation on the cases of latent virus reactivation and co-infection in COVID-19 patients to build collective evidence contributing to improving patient health. The aim of the study was to conduct a literature review to compare the patient characteristics and outcomes of reactivations and co-infections of different viruses. Methods Our population of interest included confirmed COVID-19 patients who were diagnosed with a viral infection either concurrently or following their COVID-19 diagnosis. We extracted the relevant literature through a systematic search using the key terms in the online databases including the EMBASE, MEDLINE, Latin American Caribbean Health Sciences Literature (LILACS), from inception onwards up to June 2022. The authors independently extracted data from eligible studies and assessed the risk of bias using the Consensus-based Clinical Case Reporting (CARE) guidelines and the Newcastle–Ottawa Scale (NOS). Main patient characteristics, frequency of each manifestation, and diagnostic criteria used in studies were summarized in tables. Results In total, 53 articles were included in this review. We identified 40 reactivation studies, 8 coinfection studies, and 5 studies where concomitant infection in COVID-19 patients was not distinguished as either reactivation or coinfection. Data were extracted for 12 viruses including IAV, IBV, EBV, CMV, VZV, HHV-1, HHV-2, HHV-6, HHV-7, HHV-8, HBV, and Parvovirus B19. EBV, HHV-1, and CMV were most frequently observed within the reactivation cohort, whereas IAV and EBV within the coinfection cohort. In both reactivation and coinfection groups, patients reported cardiovascular disease, diabetes, and immunosuppression as comorbidities, acute kidney injury as complication, and lymphopenia and elevated D-dimer and CRP levels from blood tests. Common pharmaceutical interventions in two groups included steroids and antivirals. Conclusion Overall, these findings expand our knowledge on the characteristics of COVID-19 patients with viral reactivations and co-infections. Our experience with current review indicates a need for further investigations on virus reactivation and coinfection among COVID-19 patients.

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Section: Resultsmentioning

confidence: 99%

Viral reactivations and co-infections in COVID-19 patients: a systematic review

et al. 2023

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“…Magri et al (13) also reported a rare case of KS following severe acute respiratory syndrome coronavirus 2 (SarS-CoV-2) infection in an 83-year-old female patient. they considered that various cofactors may have been involved in the development of KS, including steroid administration, older age, and infection with SarS-CoV-2 (13). Synchronous tumors in the same individual are regarded as a subject of interest with the hope of shedding light on the factors that are involved in promoting the neoplastic process or identifying criteria that place an individual at risk of developing various malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, another epidemiological study revealed a high risk of KS in patients with psoriasis (17). Magri et al (13) also reported a rare case of KS following severe acute respiratory syndrome coronavirus 2 (SarS-CoV-2) infection in an 83-year-old female patient. they considered that various cofactors may have been involved in the development of KS, including steroid administration, older age, and infection with SarS-CoV-2 (13).…”

Section: Discussionmentioning

confidence: 99%

“…Another study reported that the incidence of KS was 200-fold higher in recipients of organ transplants in comparison to the general population ( 11 ). The exact etiology of KS has yet to be understood; however, infection with HHV-8 is strongly related to the neoplasm, and it has been reported in >95% of KS cases of all epidemiological forms ( 13 ). It can affect the coding of the factors and cytokines that regulate cellular proliferation, immune responses and apoptosis, inducing the transformation of endothelial cells ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Kaposi sarcoma and renal cell carcinoma in an elderly male patient (a very uncommon reported entity): A case report

Bapir

Shabur²,

Aghaways

et al. 2023

Med Int

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Based on the literature, there are only three reports available to date on synchronous Kaposi sarcoma (KS) and renal cell carcinoma (rCC), at least to the best of our knowledge. the present study reports a rare case of synchronous classic KS and clear cell rCC. a 69-year-old male presented with painful, purplish nodular lesions on the dorsal aspect of his hands and feet. He had no chronic medical illnesses or prior surgical interventions. an excisional biopsy of one of the lesions revealed a nodular dermal lesion with numerous vascular channels and interlacing spindle cells. a 2.5 cm-enhancing mass was found in a contrast-enhanced computed tomography scan of the abdomen, suggesting rCC or metastasis. a partial nephrectomy was performed, and the histopathological findings were consistent with clear cell RCC. the patient responded well to paclitaxel and topical imiquimod (5%), and the skin lesions disappeared. Both KS and rCC are vascular tumors, and their pathogenesis is commonly affected by an angiogenic factor known as vascular endothelial growth factor (VEGF). a complete response of KS was observed after sorafenib, an inhibitor of VEGF receptors, was administered for the treatment of metastatic renal cancer. this reinforces the fact that there is a common therapeutic and pathogenetic pathway between these two neoplasms. Synchronous KS and clear cell RCC are rare findings. Their simultaneous appearance may be triggered by the common enhancing angiogenic factor, VEGF.

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“…Hypotheses have been published regarding the action of SARS-Cov 2 in triggering the reactivation of other viruses such as HHV-6, HHV-8 and EBV [2,3].…”

Section: Introductionmentioning

confidence: 99%