New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs

Jesus, Ana Rita; Raposo, Luís R.; Soromenho, Mário R. C.; Agostinho, Daniela A.S.; Esperança, José M. S. S.; Baptista, Pedro V.; Fernandes, Alexandra R.; Reis, Patrícia M.

doi:10.3390/sym13112053

Cited by 17 publications

(11 citation statements)

References 32 publications

(43 reference statements)

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“…The membranes obtained from the polysulfone blends based on ammonium ionic liquids present slightly higher efficiency compared with those developed by the membranes obtained from the polysulfone blends based on phosphonium ionic liquids. The higher affinity of diclofenac for ammonium ionic liquids could be attributed to the greater electrostatic or intermolecular interactions between the diclofenac salt and ammonium cation compared with the phosphonium cation [ 68 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

“…Sci. 2022, 23, x FOR PEER REVIEW 13 of 20 higher affinity of diclofenac for ammonium ionic liquids could be attributed to the greater electrostatic or intermolecular interactions between the diclofenac salt and ammonium cation compared with the phosphonium cation [68,69]. Following the obtained results, and due to the improvement efficiency of the membranes obtained from the PSFQ/Aliquat 336 solutions, they were used in the treatment process of water with higher diclofenac content (5 and 10 mg L −1 ).…”

Section: Membrane Efficiency In the Treatment Process Of Water Contai...mentioning

confidence: 88%

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Green Blends Based on Ionic Liquids with Improved Performance for Membrane Technology: Perspectives for Environmental Applications

Filimon¹,

Dobos²,

Dumbrava³

et al. 2022

IJMS

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Present research was directed towards the development of new high-performance and cost-effective polysulfone membranes (PSFQ) by introducing ionic liquids (ILs—Cyphos 101 IL and Aliquat 336) into their matrix. Variation of ILs was performed with the aim to find the one that brings new properties and improves the functionality and selectivity of PSFQ membranes in ultrafiltration processes. Based on the obtained results of the rheological study, we established the compatibility of compounds and optimal content of the used ILs, namely 3 wt% and 15 wt% Cyphos 101 IL and compositions varying between 3 and 15 wt % Aliquat 336. Results indicated that the ILs acted as plasticizers when they were added to the system, a helpful aspect in processing membranes used in water decontamination. The efficiency and performance of the membranes were evaluated by their use in the treatment of diclofenac (DCF)-containing waters. Membranes obtained from PSFQ/Aliquat 336 solution containing 15 wt% IL exhibited a 97% removal degree of DCF in the treatment process of 50 mL solution containing 3 mg/L DCF. The separation efficiency was kept constant for four filtration/cleaning cycles. The results indicated an improvement in membrane performance as the amount of IL in their structure increased, which confirms the potential for application in water treatment processes.

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Section: Resultsmentioning

confidence: 99%

Section: Membrane Efficiency In the Treatment Process Of Water Contai...mentioning

confidence: 88%

Green Blends Based on Ionic Liquids with Improved Performance for Membrane Technology: Perspectives for Environmental Applications

Filimon¹,

Dobos²,

Dumbrava³

et al. 2022

IJMS

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show abstract

“…ILs have attracted significant interest in the pharmaceutical industry as compared to existing organic solvents due to several key advantages, which include adjustable properties such as low volatility, hydrophobicity, conductivity, good solvating interactions with organic and inorganic compounds as well as high thermal and chemical stability [ 50 , 51 , 52 ]. Recently, scientists have explored the use of ILs to address issues such as low solubility and permeability of therapeutics [ 53 , 54 ] and improve drug bioavailability and stability [ 55 ]. For example, choline bicarbonate and geranic acid (CAGE) based ILs ( Figure 4 ) have been developed for transdermal delivery of insulin [ 56 ].…”

Section: Chemical Enhancersmentioning

confidence: 99%

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery

et al. 2023

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The use of the transdermal delivery system has recently gained ample recognition due to the ability to deliver drug molecules across the skin membrane, serving as an alternative to conventional oral or injectable routes. Subcutaneous insulin injection is the mainstay treatment for diabetes mellitus which often leads to non-compliance among patients, especially in younger patients. Apart from its invasiveness, the long-term consequences of insulin injection cause the development of physical trauma, which includes lipohypertrophy at the site of administration, scarring, infection, and sometimes nerve damage. Hence, there is a quest for a better alternative to drug delivery that is non-invasive and easily adaptable. One of the potential solutions is the transdermal delivery method. However, the stratum corneum (the top layer of skin) is the greatest barrier in transporting large molecules like insulin. Therefore, various chemical enhancers have been proposed to promote stratum corneum permeability, or they are designed to increase the permeability of the full epidermis, such as the use of ionic liquid, peptides, chemical pre-treatment as well as packaging insulin with carriers or nanoparticles. In this review, the recent progress in the development of chemical enhancers for transdermal insulin delivery is discussed along with the possible mechanistic of action and the potential outlook on the proposed permeation approaches in comparison to other therapeutical drugs

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“…Since ILs do not emit toxic organic compounds into the environment and are biocompatible, they are considered as green and sustainable solvents. Particularly, Chn ILs because of their lower toxicity and high biodegradability are becoming the choice for replacing organic solvents and also other families of ILs. − A schematic representation of the effect of organic solvents and ILs on the native state of proteins is provided in Scheme .…”

Section: Advantages Of Cholinium-based Ionic Liquids Over Organic Sol...mentioning

confidence: 99%

Contemporary Advancement of Cholinium-Based Ionic Liquids for Protein Stability and Long-Term Storage: Past, Present, and Future Outlook

Sindhu

Kumar

Venkatesu

2022

ACS Sustainable Chem. Eng.

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In the past two decades, ionic liquids (ILs) have been acknowledged as potentially attractive “green” and “designer” solvents since their broader chemical space and the tunable nature of the diverse ions can finely modulate their physiochemical properties while enabling task-specific optimization. They have found numerous applications in fields ranging from enzymatic reactions to protein preservation, which focused on the development of various types of ILs and their application for providing protein stability in vitro. Among various families of ILs, some of them have serious limitations similar to organic solvents; they cause environmental toxicity as they are non-biodegradable. In other words, some of the ILs impart stress to biomolecules and ultimately denature the protein. In this regard, the need for biocompatible ILs has come to the light and cholinium-based ILs (Chn ILs) have proved themselves as the most promising ILs to support the structure of biomolecules. The family of Chn ILs has only taken growth in recent years. Despite the numerous studies, more exhaustive research in the field of Chn ILs and biomolecules still needs acceleration. Herein, we review the strategies and current progress on Chn ILs for protein and enzyme-based applications keeping in mind all crucial past and present research outcomes. Furthermore, we elucidate an overview of the various ways to enhance enzymatic activity, structural stability, and long-term storage of proteins in the presence of Chn ILs. We believe these insights will be fruitful for designing various processes based on ILs in the diverse field of biotechnology and ILs will serve as novel solvents for protein stability and enzymatic reactions, maintaining their utility in industrial and biomedical based applications. The huge varieties of biobased Chn ILs hold the promise of recent advances and developments for the correct selection of long-term storage of enzymes.

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New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs

Cited by 17 publications

References 32 publications

Green Blends Based on Ionic Liquids with Improved Performance for Membrane Technology: Perspectives for Environmental Applications

Green Blends Based on Ionic Liquids with Improved Performance for Membrane Technology: Perspectives for Environmental Applications

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery

Contemporary Advancement of Cholinium-Based Ionic Liquids for Protein Stability and Long-Term Storage: Past, Present, and Future Outlook

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