New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II

Agostinho, Daniela A.S.; Santos, Filipa; Esperança, José M. S. S.; Duarte, Ana Rita C.; Reis, Patrícia M.

doi:10.1016/j.jil.2021.100003

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…ILs have attracted significant interest in the pharmaceutical industry as compared to existing organic solvents due to several key advantages, which include adjustable properties such as low volatility, hydrophobicity, conductivity, good solvating interactions with organic and inorganic compounds as well as high thermal and chemical stability [ 50 , 51 , 52 ]. Recently, scientists have explored the use of ILs to address issues such as low solubility and permeability of therapeutics [ 53 , 54 ] and improve drug bioavailability and stability [ 55 ].…”

Section: Chemical Enhancersmentioning

confidence: 99%

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery

et al. 2023

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The use of the transdermal delivery system has recently gained ample recognition due to the ability to deliver drug molecules across the skin membrane, serving as an alternative to conventional oral or injectable routes. Subcutaneous insulin injection is the mainstay treatment for diabetes mellitus which often leads to non-compliance among patients, especially in younger patients. Apart from its invasiveness, the long-term consequences of insulin injection cause the development of physical trauma, which includes lipohypertrophy at the site of administration, scarring, infection, and sometimes nerve damage. Hence, there is a quest for a better alternative to drug delivery that is non-invasive and easily adaptable. One of the potential solutions is the transdermal delivery method. However, the stratum corneum (the top layer of skin) is the greatest barrier in transporting large molecules like insulin. Therefore, various chemical enhancers have been proposed to promote stratum corneum permeability, or they are designed to increase the permeability of the full epidermis, such as the use of ionic liquid, peptides, chemical pre-treatment as well as packaging insulin with carriers or nanoparticles. In this review, the recent progress in the development of chemical enhancers for transdermal insulin delivery is discussed along with the possible mechanistic of action and the potential outlook on the proposed permeation approaches in comparison to other therapeutical drugs

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Section: Chemical Enhancersmentioning

confidence: 99%

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery

et al. 2023

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“…Four new dianionic ILs containing a succinyl-DLalaninate anion keeping some N-alkyl cholinium cation were also synthesized (Figure 1c). Our research group already reported that dianionic ionic liquids based on ammonium cations and carboxylic and/or phosphonate anions are able to increase the solubility of ibuprofen and piroxicam, but all of them presented an IC50 between 55-120 mM [22,23].…”

Section: Introductionmentioning

confidence: 99%

New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs

et al. 2021

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In this work, we prepared new biocompatible N-alkyl cholinium-based ionic liquids to be used as cosolvents to improve the solubility of poorly water-soluble drugs, namely, sodium diclofenac and paracetamol. In this set of ionic liquids, we intend to understand the effect of increasing the asymmetry of the ionic liquid cation/anion by growing the length of one of the alkyl chains attached to the nitrogen center/sulfonate center on the dissolution capacity of the ionic liquid. The addition of these new ionic liquids to water increased the dissolution capacity of the drugs up to four-times that in water, and improved the pharmacodynamic properties of these drugs, especially the case of sodium diclofenac. The intermolecular interactions between the drugs and ionic liquids were investigated by NMR. Two-dimensional 1H/1H nuclear overhauser effect spectroscopy (NOESY) revealed an interaction between sodium diclofenac and the alaninate anion from the [C2Ch]2[SucAla]. In the case of paracetamol and [C4Ch][C2SO3], it was possible to observe two intermolecular interactions between the hydroxyl group of paracetamol and two protons from the cation [C4Ch]+. Interestingly, the ionic liquid bearing a succinyl-DL-alaninate anion, [SucAla]2−, and a N-ethyl cholinium cation, [C2Ch]+, which presented the highest ability to dissolve sodium diclofenac, showed no cytotoxicity up to 500 mM. Therefore, this ionic liquid is a potential candidate for drug delivery applications.

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Unlocking the Anticancer Potential of Ionic Liquids

Mohd Noor,

Elgharbawy,

Moniruzzaman

et al. 2023

ChemBioEng Reviews

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Despite advances in cancer treatment, many types of cancer still have high mortality rates, and the existing therapies can cause considerable side effects. Therefore, discovering new therapies, especially ones with fewer side effects, is desirable to improve the outcomes for cancer patients. Ionic liquids (ILs) have emerged as potential candidates for cancer treatment because of their particular physicochemical properties, which can be tailored for specific applications. In recent years, interest in exploring the potential of ILs in cancer treatment has been growing, and several studies have demonstrated the effectiveness of ILs in inhibiting cancer‐cell growth. This review provides insight into the anticancer potential of ILs, exploring the diverse applications and the underlying mechanisms behind the cytotoxicity toward cancer cells of ILs. Understanding the mechanisms behind the cytotoxicity of ILs can aid in the design and optimization of IL‐based cancer therapies. By focusing on specific pathways and targets, IL‐based cancer therapies may be developed that offer new possibilities for treating this devastating disease.

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New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II

Cited by 8 publications

References 39 publications

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery

New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs

Unlocking the Anticancer Potential of Ionic Liquids

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