New nanostructural biomaterials based on active silicate systems and hydroxyapatite: characterization and genotoxicity in human peripheral blood lymphocytes

Abstract

The significantly improved setting characteristics and low genotoxic risk of the new material support further research.

Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study

“…Beside lower cytotoxicity found in the present study, HA‐CS has previously been related to have lower genotoxic potential in human lymphocytes (Opačić‐Galić et al . ).…”

“…Taking into account previously reported data, indicating good mechanical properties, short setting time and low genotoxicity (Opačić‐Galić et al . ), as well as significantly lower cytotoxicity and inflammation, that is better biocompatibility than MTA, both nanostructural biomaterials based on active silicate systems and hydroxyapatite, especially HA‐CS, could be candidates for future clinical studies.…”

“…CS and HA‐CS were synthesized according to the protocol explained previously and mixed with distilled water in a powder‐to‐liquid ratio of 2 : 1 (Opačić‐Galić et al . ). MTA (White MTA, Angelus ® Soluções Odontológicas, Londrina, Brazil) was used as a control material.…”

“…Both CS and HA‐CS are nanostructural materials containing agglomerates, several micrometres in size, formed by smaller particles, 117–447 nm in size, which contain even smaller building blocks, 20‐nm‐sized crystallites (Opačić‐Galić et al . ). Particle size affects cement hydration and consequently setting time and final quality of the cement.…”

“…The nanostructure of the newly synthesized materials improves particle activity and shortens setting time to 10 min (CS) and 15 min (HA‐CS) (Opačić‐Galić et al . ). Fast setting is a clear clinical advantage whilst cement composition and internal nanostructure are expected to provide biological behaviour in vital tissues.…”