New (N,O) Schiff bases of 2-hydroxynaphthaldehyde and their homoleptic Zn(II) and Cu(II) complexes – Synthesis, structural characterization, Hirshfeld surface analysis and antimicrobial activity studies

Satheesh, C.E.; Kumar, P. Raghavendra; Suchetan, P.A.; Rajanaika, H.; Foro, Sabine

doi:10.1016/j.ica.2020.120017

Inorganica Chimica Acta

2021

DOI: 10.1016/j.ica.2020.120017

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New (N,O) Schiff bases of 2-hydroxynaphthaldehyde and their homoleptic Zn(II) and Cu(II) complexes – Synthesis, structural characterization, Hirshfeld surface analysis and antimicrobial activity studies

C.E. Satheesh

P. Raghavendra Kumar

P.A. Suchetan

et al.

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Cited by 3 publications

References 94 publications

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Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

Dalal,

Devi,

Antil

et al. 2023

Applied Organom Chemis

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In this study, Schiff base ligand 1,1′‐((propane‐1,3‐diylbis [azaneylylidene]) bis (methaneylylidene))bis (naphthalen‐2‐ol) based Organyltellurium (IV) complexes were synthesized with formulae C32H27ClN2O3Te (5a)\C31H25ClN2O3Te (5b)\C32H27ClN2O3Te (5c)\ C39H34N2O4Te (5d)\ C37H30N2O4Te (5e)\ C39H34N2O4Te (5f) for acquiring a potential therapeutic agent. The synthesized compounds were characterized by ultraviolet–visible (UV–Vis), FT‐IR, 1H‐NMR, 13C‐NMR, mass spectrometry, molar conductance, elemental analysis, powder X‐ray diffraction and EDAX, which states that the tetradentate Schiff base ligand (HNDP) coordinated via oxygen and nitrogen atom with tellurium giving hexa‐coordinated tellurium (IV) complexes. The thermal features of the ligand and complexes were studied using thermal (TGA and DTG) technique. The biochemical behavior of the Schiff base and its complexes was assessed by examining their reactivity against various microbial strains, DPPH free radicals as well as normal and cancer cells. The complex 5c exhibited the highest inhibition activity against bacterial strains while complex 5f showed the strongest inhibition activity against fungal strains. Complexes 5e and 5f displayed the most effective suppression of DPPH free radicals. The results of in vitro cytotoxicity study revealed that complex 5a demonstrated moderate cytotoxic effect on the L929 cell lines. Complex 5c displayed a significant cytotoxic effect on the PC3 cell line. Moreover, complex 5a, 5c and 5e exhibited the best cytotoxic activity against the Saos‐2 cell line. Additionally, the structural forms of synthesized compounds were elucidated by DFT study. Furthermore, pharmacokinetic ADMET properties were estimated for their drug similarity behavior. The results advocate that complexes can be utilized as biological drugs.

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Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

Dalal,

Devi,

Antil

et al. 2023

Applied Organom Chemis

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Synthesis, structural investigation of Schiff base endowed organyltellurium(IV) complexes: biological activities, molecular docking, quantum chemical computations and ADMET prediction

et al. 2023

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Multifunctional Polysiloxane with coordinative ligand for ion recognition, reprocessable elastomer, and reconfigurable shape memory

Wang

Fan

et al. 2021

Polymer

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New (N,O) Schiff bases of 2-hydroxynaphthaldehyde and their homoleptic Zn(II) and Cu(II) complexes – Synthesis, structural characterization, Hirshfeld surface analysis and antimicrobial activity studies

Cited by 3 publications

References 94 publications

Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

Synthesis, structural investigation of Schiff base endowed organyltellurium(IV) complexes: biological activities, molecular docking, quantum chemical computations and ADMET prediction

Multifunctional Polysiloxane with coordinative ligand for ion recognition, reprocessable elastomer, and reconfigurable shape memory

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