Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

Abstract

In this study, Schiff base ligand 1,1′‐((propane‐1,3‐diylbis [azaneylylidene]) bis (methaneylylidene))bis (naphthalen‐2‐ol) based Organyltellurium (IV) complexes were synthesized with formulae C32H27ClN2O3Te (5a)\C31H25ClN2O3Te (5b)\C32H27ClN2O3Te (5c)\ C39H34N2O4Te (5d)\ C37H30N2O4Te (5e)\ C39H34N2O4Te (5f) for acquiring a potential therapeutic agent. The synthesized compounds were characterized by ultraviolet–visible (UV–Vis), FT‐IR, 1H‐NMR, 13C‐NMR, mass spectrometry, molar conductance, elemental analysis, powder X‐ray diffraction and EDAX, which states that the tetradentate Schiff base ligand (HNDP) coordinated via oxygen and nitrogen atom with tellurium giving hexa‐coordinated tellurium (IV) complexes. The thermal features of the ligand and complexes were studied using thermal (TGA and DTG) technique. The biochemical behavior of the Schiff base and its complexes was assessed by examining their reactivity against various microbial strains, DPPH free radicals as well as normal and cancer cells. The complex 5c exhibited the highest inhibition activity against bacterial strains while complex 5f showed the strongest inhibition activity against fungal strains. Complexes 5e and 5f displayed the most effective suppression of DPPH free radicals. The results of in vitro cytotoxicity study revealed that complex 5a demonstrated moderate cytotoxic effect on the L929 cell lines. Complex 5c displayed a significant cytotoxic effect on the PC3 cell line. Moreover, complex 5a, 5c and 5e exhibited the best cytotoxic activity against the Saos‐2 cell line. Additionally, the structural forms of synthesized compounds were elucidated by DFT study. Furthermore, pharmacokinetic ADMET properties were estimated for their drug similarity behavior. The results advocate that complexes can be utilized as biological drugs.

Thiosemicarbazone ligands based transition metal complexes: A multifaceted investigation of antituberculosis, anti‐inflammatory, antibacterial, antifungal activities, and molecular docking, density functional theory, molecular electrostatic potential, absorption, distribution, metabolism, excretion, and toxicity studies

“…In the context of anti-TB analysis, complex (10) demonstrated a higher level of effectiveness (MIC value 0.006 ± 0.001 μmol/mL) that was nearly double than the streptomycin, meanwhile, complexes (6) and ( 9) exhibit comparable TB inhibition ability to streptomycin. The examination of anti-inflammatory properties of compounds (1-10) showed that again complex (10) has the lowest and comparable IC 50 value (6.75 ± 0.09 μM) to diclofenac sodium which signifies its superior efficacy in managing inflammation deformities, whereas (5), ( 6), (8), and (9) exhibit significant inflammation inhibition efficacy. In the antibacterial and antifungal investigations, again complex (10) (0.0066 μmol/mL) has a comparable MIC value to standard drugs against S. aureus, B. subtilis, E. coli, P. aeruginosa, and R. oryzae, whereas it was proved to be more efficient (0.0066 μmol/mL) in controlling C. albicans deformities in comparison of fluconazole.…”

“…Subsequently, a 30 mL methanolic solution of thiosemicarbazone ligands HL 1 (1) or HL 2 (2) was stirred for 3-4 h with cobalt (II), nickel (II), copper (II), zinc (II) acetates in a 2:1 M ratio to form complexes (3)(4)(5)(6)(7)(8)(9)(10). The obtained different colored solid compounds were washed with methanol and further purified through recrystallization in THF (Scheme 1).…”

“…The anti-inflammatory properties of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) were investigated in triplicate by BSA assay utilizing diclofenac sodium as positive control and DMSO as negative control. DMSO was used to make solutions with concentrations ranging from 200 to 12.5 μg/mL using diluted phosphate buffer (0.2 M, pH 7.4).…”

“…6 These complexes find applications in diverse fields such as catalysis, materials science, and medicinal chemistry. As a result, these properties have prompted their utilization in various biomedical applications, including anticancer, 7 antibacterial, 8 antifungal, 9 antimalarial, 10 anti-inflammatory, 11 and antituberculosis 12 endeavors. Consequently, research on these metal complexes are worth mentioning.…”

“…In our continuous endeavor to develop efficacious anti-infectious pharmaceuticals, with a specific emphasis on combatting TB, inflammation, bacterial, fungal infections, the microplate Alamar Blue, bovine serum albumin (BSA), and serial dilution protocols were employed to evaluate the therapeutic potential of previously synthesized thiosemicarbazone ligands (1-2) and their Co (II), Ni (II), Cu (II) complexes (3)(4)(5)(6)(7)(8)(9)(10) which are based on benzaldehyde derivatives and 4-(4-ethylphenyl)-3-thiosemicarbazide. 4 Furthermore, molecular docking (against 6H53 and 1CX2 proteins), DFT, MESP and ADMET investigations were conducted to support the biological evaluations.…”