In present study, six new organyltellurium(IV) Schiff base complexes with the formula RTeCl2·H4AP
(1a-c) and R2TeCl·H4AP (1d-f), where R= 4-methoxyphenyl, 4-hydroxyphenyl and
3-methyl-4-hydroxyphenyl, ligand H4AP = 1-(((4-hydroxyphenyl)imino)methyl)-naphthalen-2-ol
obtained from the condensation of 2-hydroxy-1-naphthaldehyde with 4-aminophenol were synthesized
and characterized by elemental analysis, molar conductance, mass spectrometry, FT-IR, UV-visible,
1H NMR, 13C NMR spectroscopy. Correlation of all spectroscopic data suggested that Schiff base
ligand (H4AP) acts as bidentate (ON) ligand coordinated to tellurium ion via naphthalene ring-O and
imine-N with the distorted square pyramidal geometry around the tellurium ion. DFT based calculations
were done for the ligand and its metal complexes to confirm the geometry of complexes. Chemical
quantum parameters were determined for the ligand and the complexes. The antioxidant activity of
the Schiff base and their organyltellurium(IV) complexes were assessed on the basis of radical
scavenging effect of DPPH. The free Schiff base and its complexes were screened for the in vitro
antifungal and antibacterial activity. The results show that the organyltellurium(IV) complexes were
more active than the Schiff base. The molecular docking simulations carried out to study the probable
binding modes of the ligand with various proteins receptors such as C. albicans and E. coli.
Schiff base ligand (3-((4-mercaptophenyl)imino)-1-phenylindolin-2-one) of 1-phenylindoline-2,3-dione
and 4-aminothiophenol was synthesized by refluxing. Organotellurium(IV) complexes of type
(RTeCl3.NPhIATP and R2TeCl2.NPhIATP, where R = 4-hydroxyphenyl, 4-methoxyphenyl and
3-methyl-4-hydroxyphenyl, NPhIATP = Schiff base ligand). The ligand and its organotellurium(IV)
complexes (9a-f) were characterized by FT-IR, molar conductance, elemental analyses, UV-vis, mass,
1H & 13C NMR spectral studies. Geometry of all the compounds were optimized and octahedral geometry
have been proposed for all the tellurium(IV) complexes. Molecular docking was studied to find the
binding interactions between ligand (NPhIATP) and receptor proteins: E. coli (3t88) and S. aureus
(3ty7). The antimicrobial activity of ligand and its tellurium(IV) complexes have been screened against
bacteria and fungi. All the organotellurium(IV) complexes complexes showed good activity to ligand
towards different studied microorganisms.
Condensation of 5-(hydroxymethyl)furan-2-carboxaldehyde with 4-toluidine yielded a Schiff base
(5-((p-tolylimino)methyl)furan-2-ol). A series of seven novel hexa-coordinated organyltellurium(IV)
complexes of type TeCl4·HMeFPT, RTeCl3·HMeFPT and R2TeCl2·HMeFPT (where R belongs to
4-methoxyphenyl, 4-hydroxyphenyl and 3-methyl-4-hydroxyphenyl; L belongs to HMeFPT i.e. Schiff
base have been prepared and characterized by molar conductance, IR, UV, 1H NMR, 13C NMR, mass
spectroscopy and elemental analysis. Thus according to spectroscopic studies, Schiff base ligand
functions as a NO donor bidentate ligand across all organyltellurium(IV) complexes via the azomethine
nitrogen atom and the oxygen atom of the furan ring. The above mentioned spectroscopic analysis
indicated that all the organyltellurium(IV) complexes have distorted octahedral geometry. Schiff base
and all the organyltellurium(IV) complexes had their geometry optimized and theoretical quantum
mechanical characteristics computed. The octahedral geometry for complexes is also suggested by
this computing analysis. The antimicrobial property of the Schiff base ligand and its
organyltellurium(IV) complexes was evaluated in vitro against different bacterial strains viz. A. clavatus,
C. albicans, A. niger, S. pyogenes, S. aureus, E. coli and P. aerugenosa. Antimicrobial property of
heterocyclic bidentate Schiff base and its organyltellurium(IV) complexes was found to be significantly
greater than that of some standard antibiotics.
Organyltellurium(IV) complexes of Schiff base (MeFPT = 4-methyl-N-((5-methylfuran-2-
yl)methylene)aniline) derived from condensation reaction of 5-methyl furan-2-carboxaldehyde with
p-toluidine having formula of type MeFPT·RTeCl3 and MeFPT·R2TeCl2 (R = 4-hydroxy-phenyl,
4-methoxyphenyl or 3-methyl-4-hydroxyphenyl) were reported. These complexes have been
characterized by elemental analysis, IR, 1H NMR, 13C NMR, UV-Vis, DFT, molecular modelling and
mass spectra. The experimental data demonstrated that formed Schiff base complexes behaved as
bidentate ligand with R1TeCl3 and R2TeCl2 chelated by neutral N and O atoms having distorted octahedral
stereochemistry in all organyltellurium(IV) complexes. Schiff base and its organyltellurium(IV)
complexes exhibited considerable biological activity. The antibacterial and antifungal activity have
been carried out and the results were compared with some known antibiotics.
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