New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents

Abstract

This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurement of the template propranolol from its molecularly imprinted polymer (MIP) using a quaternary ammonium ion in toluene, shows that this MIP behaves as an ion exchanger even in a non-polar solvent. The same experiment also shows that template binding to the MIP from toluene involves ionic interaction. The third experimental method introduced here serves to study the models of template binding on MIPs. To this end the binding isotherm of propranolol (PR) has been measured on a polymer mixture consisting of non-imprinted control polymer (NIP) and a stronger binding acidic polymer, respectively. All three methods are suitable for studying several other imprinting systems.

Molecularly imprinted polymer‐based optical immunosensors

“…For this reason, solvents are named porogens in the MIP process. [7] 4. Initiators will initiate the polymerization step followed by propagation.…”

“…For this reason, solvents are named porogens in the MIP process. [ 7 ] Initiators will initiate the polymerization step followed by propagation. Initiators are produced either by free radical mechanism or by thermal decomposition. Removal of the template is the next step which permits the construction of molecular recognition sites with defined size and shape.…”

Recent Advances and Future Prospects of Molecular Imprinting Polymers as a Recognition Sensing System for Food Analysis: A Review

“…The assortment of approaches for creating manufactured receptors can be categorized into reversible covalent or non-covalent (hydrogen, ionic, and Van der Waals) techniques, depending on the cooperation between the monomer and the layout. Generally, most MIPs are arranged by mass polymerization, which has a poor site of objective particles and a low rebinding limit because of a thick polymeric matrix [3].…”

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

“…Typically, this solvent is named as porogen due to its capacity to artificially include pores within the polymeric network in the micro- and meso-scale ranges [6]. It is worth to mention the importance of its nature, that should ensure the stability of the FM-T complex and do not interfere with the monomers during the propagation step of the polymerization, according to its polarity, dispersive forces and capacity to form H bonds [7,8]. Experimentally, it has been observed that using the same solvent during the recognition step as that used for the polymerization enhances the diffusion of the template to the recognition pockets, as the polymeric matrix keeps a kind of “memory effect” regarding its swelling properties [9].…”