Molecularly imprinted polymer‐based optical immunosensors

Abstract

Molecularly imprinted polymers (MIPs) are artificial antibodies for a target molecule. The review focuses mainly on mechanistic steps involved in forming MIPs and the role of co‐monomers and porogen. In addition, the electronic transition between different energy levels is explained with the help of the Jablonski diagram. Diverse receptor and target molecules for anchoring artificial MIPs are discussed, accentuating the synergetic effects obtained. The binding efficiency, selectivity, and sensitivity of various optical sensors are discussed intensively. In addition to this, we focused on synthesis, physical forms, characterization techniques, and microorganism detection of imprinted polymers. A brief investigation on the use of MIPs in cancer diagnosis is also included, and attention is extended to the important challenges faced in using imprinted polymers.

Smart and intelligent optical materials for sensing applications

“…The review highlighted the experimental setups, the limit of detection (LOD), and the specificity and sensitivity, as well as the prominent biosensor platform based on LC. Singh and Natarajan [14] emphasized the mechanistic steps of fabricating molecularly imprinted polymers (MIPs) and their function as co‐monomers. The absorbance in ground and excited states was elucidated using a Jablonski diagram.…”

State-of-the-Art Smart and Intelligent Nanobiosensors for SARS-CoV-2 Diagnosis

“…Therefore, artificial biorecognition systems based on molecularly imprinted polymers (MIPs) have been established, and have attracted attention as a probable substitute in recent years. Molecularly imprinted polymers are developed using the molecular imprinting method, which can be described as a method of template establishment of particular molecular recognition sites in a polymer material [ 146 ]. MIP is a technique for manufacturing affinity polymers for different targets of analytical interest.…”

Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

“…[113] Currently, conducting polymers like polypyrrole (PPy) and polyaniline (PANI) have been copolymerized using various processes with nanoparticles like, carbon nanotubes (CNTs), metal NPs, and, graphene, However composite with MIPs, sol-gel, and newly ionic liquids (ILs), other applicable dopants (clays, montmorillonites, and zeolites) also with biopolymers (chitin, chitosan, cellulose, proteins and gelatin) to generate nanocomposites such that the overall properties of each element can be improved for better biosensing detection. [114][115][116] Polymer-based NPs are one of the nanomaterials with great biodegradability and biological safety. Solid colloidal particles having a particle diameter of 10 to 500 nm and bioactive substances that are internalized via wrapping, dissolving, or adsorption and adhesion upon the particle surface constitute polymer-based nano-controlled release system.…”