New Method Development for Hydroxyzine Determination: Application in Stability Studies, Pharmaceutical Formulations, and Humane Serum

Sher, Nawab; Siddiqui, Farhan Ahmed; Fatima, Nasreen; Perveen, Shahnaz; Shafi, Nighat

doi:10.1080/10826076.2014.991871

Cited by 18 publications

(9 citation statements)

References 28 publications

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“…Complete degradation with formation of N -desmethyldiazepam was reported after exposure of clorazepate dipotassium salt to sunlight for 4 days (Burana-Osot et al 2015 ). Amongst non-benzodiazepine anxiolytics, hydroxyzine (Sher et al 2015 ) and meprobamate (Karthikeyan et al 2010 ) are practically photostable (sunlight and UV–VIS radiation exposure respectively). Irradiation of etifoxine with a mercury lamp for 24 h resulted in degradation of 20 % of substance and formation of two photoproducts (Djabrouhou and Guermouche 2014 ).…”

Section: Photostability Testing Of Drugsmentioning

confidence: 99%

Studies on photodegradation process of psychotropic drugs: a review

Trawiński

Skibiński

2016

Environ Sci Pollut Res

105

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Consumption of psychotropic drugs is still increasing, especially in high-income countries. One of the most crucial consequences of this fact is significant release of them to the environment. Considerable amounts of atypical antipsychotics, benzodiazepines, antidepressants, and their metabolites were detected in river, lake, and sea water, as well as in tissues of aquatic organisms. Their ecotoxicity was proved by numerous studies. It should be noticed that interaction between psychotropic pharmaceuticals and radiation may lead to formation of potentially more toxic intermediates. On the other hand, photo-assisted wastewater treatment methods can be used as an efficient way to eliminate them from the environment. Many methods based on photolysis and photocatalysis were proposed and developed recently; nevertheless, the problem is still unsolved. However, according to recent studies, photocatalysis could be considered as the most promising and far more effective than regular photolysis. An overview on photolytic as well as homogenous and heterogeneous photocatalytic degradation methods with the use of various catalysts is presented. The photostability and phototoxicity of pharmaceuticals were also discussed. Various analytical methods were used for the photodegradation research, and this issue was also compared and summarized. Use of high-resolution multistage mass spectrometry (Q-TOF, ion trap, Orbitrap) was suggested. The combined techniques such as LC–MS, GC–MS, and LC–NMR, which enable qualitative and quantitative analyses in one run, proved to be the most valuable in this case. Assembling of MS/MS spectra libraries of drug molecules and their phototransformation products was identified as the future challenge.

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Section: Photostability Testing Of Drugsmentioning

confidence: 99%

Studies on photodegradation process of psychotropic drugs: a review

Trawiński

Skibiński

2016

Environ Sci Pollut Res

105

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“…HPLC have been very frequently used in the determination of drugs molecules in various samples especially pharmaceutical and biological. [17][18][19][20] Molecules having same physio-chemical properties such as fluoroquinolones usually co-elute and chromatography becomes a challenge. Variety of analytical column packed with various stationary phases such as C 8 , C 18 , nitrile and phenyls were comprehensively investigated with different nature of mobile phases and it was noted that mobile phase has a more profound effect on resolution and retention of molecules.…”

Section: Methods Development Optimization and Validationmentioning

confidence: 99%

“…Samples were prepared in multiple and passed through 0.45 µm membrane filter, before chromatography. [17][18][19][20]…”

Section: Serum Analysismentioning

confidence: 99%

Liquid Chromatographic Determination of Dexamethasone and Fluoroquinolones; in vitro Study

Sher

Fatima

Perveen³

et al. 2019

S.Afr.j.chem.

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A precise, accurate and sensitive liquid chromatographic method is presented for the simultaneous analysis of moxifloxacin, levofloxacin, ciprofloxacin and dexamethasone in reference drugs, ophthalmic dosage form and in physiological fluids. Separation was achieved on a C 18 analytical column with acetonitrile-phosphate buffer (35:65 v/v) as mobile phase which was pumped isocratically at a flow rate of 1.0 mL min-1 and monitored at 254 nm wavelength. The calibration curve was linear in range of 40-10 000 ng mL-1. Test results in pharmaceutical and physiological samples showed excellent drug recovery (96.5-102.3 %) with good precision (0.81-2.3 % RSD). Test results were linear to sample concentration and correlation coefficient was more than 0.9990. The small value of quantification and detection levels showed the method to be sensitive enough for use in clinical and industrial investigations of all the mentioned drugs.

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“…A range of concentraton 25-10000 ng mL -1 of standard composite solutions were prepared by diluting stock standard composite solution. Linearity was determined by plotting peak area vs concentrtion which produced least-square regression calibration curves (Sher et al, 2015).…”

Section: Linearity and Rangementioning

confidence: 99%

Simultaneous determination of anti-diabetic drugs

Sher

Fatima

Perveen³

et al. 2019

Braz. J. Pharm. Sci.

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A novel reverse phase, isocratic HPLC method is described to separate five anti-diabetic drugs i.e., glimepiride, metformin, sitagliptin, rosiglitazone and pioglitazone. Nucleosil C 18 analytical column was used as stationary phase, while mobile phase consisted of acetonitrile:phosphate buffer: methanol (40/40/20, v/v) pH 2.0. Effluent was monitored at a flow rate 1 mL/min and detected at wavelength of 240 nm. This research produced excellent chromatography over a wide concentration range of 25-10000 ng/mL. Sepprated and well resolved quantifiable peaks were obtained and test results were linear in this range. Correlation coefficient of more than 0.9990 was witnessed as well as Low %RSD values i.e., maximum 2.0% documented excellent precision of the method. Good recoveries from pharmaecutical (99-101%), urine and plasma samples (>96%) in a range of concentrtion granted very good linearity, accuracy and precision. The projected method has satisfactory applications in quality control of these molecules as well as quantification of these molecules in urine and plasma samples.

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New Method Development for Hydroxyzine Determination: Application in Stability Studies, Pharmaceutical Formulations, and Humane Serum

Cited by 18 publications

References 28 publications

Studies on photodegradation process of psychotropic drugs: a review

Studies on photodegradation process of psychotropic drugs: a review

Liquid Chromatographic Determination of Dexamethasone and Fluoroquinolones; in vitro Study

Simultaneous determination of anti-diabetic drugs

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