New metal(II) complexes with ceftazidime Schiff base

Reiss, Aurora; Chifiriuc, Mariana Carmen; Amzoiu, Emilia; Cioateră, Nicoleta; Dăbuleanu, Irina; Rotaru, P.

doi:10.1007/s10973-017-6832-0

Cited by 20 publications

(13 citation statements)

References 43 publications

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“…Also, the IR spectrum of phen or bipy contains characteristic bands due to ρ(C-H) vibrations at 853 and 738 cm -1 for free phen which appear at 722, 726 cm -1 in 2 and 4 while the bands at 851 and 691 cm -1 of free bipy appear at 771, 767 cm -1 in 1 and 3. The shifts of the ring vibrations confirm the presence and coordination of phen and bipy in the complexes [35,38,39]. All spectra of the metal complexes contain bands at 504-506 cm -1 and 424-428 cm -1 which are assigned to ν(M-O) and ν(M-N), respectively [35,40].…”

Section: Structural Investigations Of Metal Complexesmentioning

confidence: 82%

New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

Reiss¹,

Mitran²,

Babeanu³

et al. 2020

Rev. Chim.

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Four mixed-ligand metal(II) complexes with the molecular formulae [M(ofl)(bipy)]NO3�H2O and [M(ofl)(phen)]NO3�H2O were synthesized by the reaction of Co(II) and Ni(II) with ofloxacin (Hofl) in the presence of 1,10-phenanthroline (phen) / 2,2`-bipyridine (bipy) (1:1:1 molar ratio). The data obtained from elemental analysis, molar conductance, spectral infrared, reflectance spectra and magnetic studies gave information about the coordination of the ligands and the geometry of the metallic ion. The results suggest that Hofl is deprotonated and bidentately bound to the metal ion through the pyridone oxygen and the carboxylato oxygen while phen and bipy act as neutral bidentate ligands coordinated through the nitrogen atoms. Tetrahedral geometry is proposed for all complexes. Thermal analysis data led to useful information concerning the composition, dehydration and thermal behaviour of the complexes. Ofloxacin and the metal complexes were tested for antibacterial activity and also for antioxidant activity. The variations of physicochemical parameters were monitored, which explain the antibacterial behaviour of these compounds. The interactions between metal complexes and bacterial receptors have lower energy values compared to the ofloxacin ligand. The molecular docking studies allow the identification of the biological target and the predictions of the bonds between the studied compounds and the receptors of E. coli (3t88), S. aureus (3q8u) and P. aeruginosa (4lkd).

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Section: Structural Investigations Of Metal Complexesmentioning

confidence: 82%

New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

Reiss¹,

Mitran²,

Babeanu³

et al. 2020

Rev. Chim.

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“…The scientific literature reports a large diversity of species concerning both metal ions and ligands available for designing such effective anti-biofilm species ranging from simple to bulky ligands and acting as unidentate to multidentate species. A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , <...>…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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“…The prepared complexes have a square planar geometry with non-electrolyte properties. Antimicrobial activity of complexes was measured through growth inhibition zone diameters against both Planktonic and biofilm embedded cells and all complexes were gave a good antimicrobial activity [31]. In 2018, Lin-Wei Z. and co-workers synthesized the new Schiff base metal complex (Tetraoxime) which is called bis-salamo, Figure13.…”

Section: Schiff Base Metal Complexesmentioning

confidence: 99%

Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review

Ibrahim

Abdalhadi²

2021

ANJS

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Schiff bases are a broad class synthesized compound, which is prepared for the condensation process between the primary amine group and an aldehyde or ketone group. Schiff base metal complexes play an important role in many applications such as biological activity, catalytic activity, and optical property. The wide range application of Schiff base metal complexes came from the versatility of Schiff base reactions with many different transition metals. This flexibility of the reactions was given these complexes, many different properties and uses in a biological human system such as antibacterial, antifungal, anticancer, antimalarial, and others. This review gives many examples of Schiff bases, metal complexes, and there ligands with biological applications in the human system.

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New metal(II) complexes with ceftazidime Schiff base

Cited by 20 publications

References 43 publications

New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review

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