Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review

Abstract

Schiff bases are a broad class synthesized compound, which is prepared for the condensation process between the primary amine group and an aldehyde or ketone group. Schiff base metal complexes play an important role in many applications such as biological activity, catalytic activity, and optical property. The wide range application of Schiff base metal complexes came from the versatility of Schiff base reactions with many different transition metals. This flexibility of the reactions was given these complexes, many different properties and uses in a biological human system such as antibacterial, antifungal, anticancer, antimalarial, and others. This review gives many examples of Schiff bases, metal complexes, and there ligands with biological applications in the human system.

Synthetic methodologies and pharmacological applications of sulphonamide containing Schiff bases and their metal complexes: A comprehensive review

“…It is generally known that the coordination of metals in the active sites of various metallo-biomolecules depends profoundly on the N, O and S atoms. [5][6][7][8][9] Sulphonamides are biologically significant class of druglike chemical derivatives. Due to their good oral absorption and urine excretion, sulphonamides are biologically relevant class of compounds.…”

Au(III) complexes of symmetrical tetradentate Schiff base ligands: Synthesis, characterization, anticancer/antioxidant potency, in silico prediction, and catalase binding properties

“…These ligands are obtained from the condensation of the carbonyl group and primary amines. Schiff bases have various biological activities such as antiviral, antibacterial, antifungal, antioxidant, and anticancer 6–10 . On the other hand, they can be coordinated to metal in various modes NX(X)N (X = N, O, S, Se, or P) 1 .…”

“…1 Among transition metals, gold(III) has received much attention. This metal with an electronic arrangement (d 8 ) similar to Pt(II) can create complexes similar to platinum (square planar). In the case of Au(III) complexes, it should be noted that Au(III) ion can easily be reduced to Au(I) or Au(0) ion under the influence of biological reductants (such as glutathione [GSH]).…”

Recent Advances in the Catalytic Applications of Chiral Schiff‐Base Ligands and Metal Complexes in Asymmetric Organic Transformations

“…[2] One of the essential features in the Schiff base structure is the presence of the azomethine group, which owes its importance to biological activities with much broad applicability. [14] Hence, they are the essential compounds in the field of biochemistry and pharmaceutical chemistry. They are mostly used as potential drugs in the form of anti-cancer, [15][16][17][18][19] anti-microbial, [20][21][22][23][24] anti-tumour, [25,26] antimalarial, [27][28][29][30][31][32] anti-inflammatory, [33,34] anti-oxidant, [35][36][37][38][39] antipyret-ic agents, [40,41] etc.…”