New insights into an old disease: advanced imaging in the diagnosis and management of gout

McQueen, Fiona; Reeves, Quentin; Dalbeth, Nicola

doi:10.1136/postgradmedj-2012-131000

Cited by 38 publications

(22 citation statements)

References 59 publications

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“…Gout is characterized by the deposition of reversible monosodium urate (MSU) crystals and occurs as a consequence of hyperuricemia [104] which induces inflammatory arthritis [105] and nephropathy [106] and has risen over the last decade. Dr. Veronique Vitart, from the Medical Research Council Human Genetics Unit at the University of Edinburgh, researcher of hyperuricemia genetics said: ‘ Abnormal levels of uric acid have been associated with various common diseases and conditions, but causal relationships are not always clear.…”

Section: Discussionmentioning

confidence: 99%

“…US and MRI also reveal the severity of inflammation within and adjacent to the joint and can capture information about the composite, vascular nature of many tophaceous deposits [104,108]. According to our recent data [109], ultrasound can be an effective method for early detection of liver and kidney involvement in gout patients with sensitivity, specificity, positive and negative predictive value and accuracy; the gout involvement of liver and kidneys using complex ultrasonography diagnostic criteria were 92.6%, 84.4%, 80%, 95% and 91.9% respectively.…”

Section: Discussionmentioning

confidence: 99%

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The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

et al. 2014

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IntroductionObesity becomes endemic today. Monosodium glutamate was proved as obesogenic food additive. Probiotics are discussed to impact on obesity development.Aims and objectivesThe aim was to study the effects of probiotics on the development of monosodium glutamate (MSG)-induced obesity in rats.Material and methodsWe included 45 Wistar male rats and divided into three groups (n = 15). Newborn rats of group 1 (control) received subcutaneously 8 μl/g saline. Group 2 received 3 to 4 mg/g MSG subcutaneously on the second, fourth, sixth, eighth and tenth day of life. Within 4 months after birth, rats were on a standard diet. Group 3 received an aqueous solution of probiotics mixture (2:1:1 Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL, B. animalis VKB) at the dose of 5 × 109 CFU/kg (50 mg/kg) intragastrically. Administration of probiotics was started at the age of 4 weeks just after weaning and continued for 3 months during 2-week courses. Group 2 received intragastrically 2.5 ml/kg water. Organometric and biochemical parameters in all groups of rats were analyzed over 4 months. The concentration of adiponectin was determined in serum, and leptin - in adipose tissue.ResultsAdministration of MSG led to the development of obesity in rats; body weight had increased by 7.9% vs controls (p < 0.05); body length had increased by 5.4% (p < 0.05). Body mass index and Lee index and visceral fat mass had increased (p < 0.001). Under the neonatal injection of MSG, the concentration of total cholesterol, triglycerides, VLDL cholesterol and LDL cholesterol significantly increased (p < 0.001), in comparison with controls. Adipose-derived hormones changed in MSG obesity rats: adiponectin decreased by 58.8% (p < 0.01), and leptin concentration in adipose tissue had increased by 74.7% (p < 0.01). The probiotic therapy of rats from group 3 prevented obesity development. Parameters of rats treated with probiotic mixture did not differ from that in the control.ConclusionsThe introduction of MSG to newborn rats caused the obesity in adulthood. Periodic administration of probiotic mixture to rat injected with MSG neonatally resulted in recovery of lipid metabolism and prevention of the obesity development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

et al. 2014

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“…Although less operator-dependent than ultrasound, the lower cost and greater accessibility of the latter are likely to make it the more popular modality for the imaging of gout [68]. …”

Section: Goutmentioning

confidence: 99%

Imaging in rheumatology: reconciling radiology and rheumatology

Tins

Butler

2013

Insights Imaging

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Imaging in rheumatology was in the past largely confined to radiographs of the hands and sacroiliac joints (SIJs) helping to establish the diagnosis and then monitoring disease progression. Radiographs are not very sensitive for early inflammation in inflammatory rheumatic disorders and the demand on imaging services was therefore limited. However, over the last 10–15 years new drugs and new technologies have brought new challenges and opportunities to rheumatology and radiology as specialties. New drug treatments allow more effective treatment, preventing many complications. Early diagnosis and disease monitoring has become the challenge for the rheumatologist and radiologist alike. The best possible patient outcome is only achieved if the two specialties understand each other’s viewpoint. This article reviews the role of imaging—in particular radiography, magnet resonance imaging, computer tomography, ultrasound and nuclear medicine—for the diagnosis and monitoring of rheumatological disorders, concentrating on rheumatoid arthritis, inflammatory spondylarthropathies and gout.Teaching Points• New drugs for the treatment of inflammatory disorders has led to greatly improved outcomes.• Imaging often allows for earlier diagnosis of inflammatory disorders.• Early diagnosis and treatment can often prevent the development of crippling disease manifestations.• Tailored imaging examinations are best achieved by consultation of rheumatologist and radiologist.

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“…Advanced imaging modalities including magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), and dual energy CT have important applications in gout and can capture information about the composite, vascular nature of many tophaceous deposits [70][71][72].…”

Section: Mets Hyperuricemia and Nephropathymentioning

confidence: 99%

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study

et al. 2017

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Background Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as nonalcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat). Materials We included 60 male rats and equally divided them to 6 groups of 10 animals in each group: the experimental groups were firstly assigned as controls and high caloric diet (HCD)-fed groups, and each group further was subdivided to remain untreated, Fenugreek bionanocomposite (BNC)-treated, and Orlistat-treated. Normal control rats (groups 1, 2, 3) were fed by a standard chow, while the others (groups 4, 5, 6) were fed with HCD ad libitum during 98 days. From days 77 to 98, groups 2 and 5 were treated with BNC based on Fenugreek (150 mg/kg body weight, orally) and groups 3 and 6 were treated with antiobesogenic drug Orlistat (10 mg/kg body weight, orally). Food and water consumptions were measured daily and body weights were measured once a week. On day 99, blood was collected; the creatinine, urea, and uric acid were estimated in serum according to the standard protocols. Levels of low and middle molecules (MMs) were measured; the quantity of oligopeptides was estimated by Bradford method. We performed the liver and kidney ultrasonography in rats.Results We revealed an increase in the levels of endogenous intoxication syndrome markers (MM and oligopeptides) in all animals with experimental obesity. Ultrasound data showed injury of the liver and kidneys in obese rats. We observed significant decreasing of MM levels after Orlistat treatment vs controls (p < 0.05). However, this effect was more pronounced in Fenugreek BNC-treated group vs both Orlistattreated and controls (p < 0.05). Orlistat treatment evoked rising of serum creatinine and oligopeptides in control animals

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New insights into an old disease: advanced imaging in the diagnosis and management of gout

Cited by 38 publications

References 59 publications

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

Imaging in rheumatology: reconciling radiology and rheumatology

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study

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