New Insight on Bio-sensing by Nano-fabricated Memristors

Sacchetto, Davide; Doucey, Marie‐Agnès; Micheli, Giovanni De; Leblebici, Yusuf; Carrara, Sandro

doi:10.1007/s12668-011-0002-9

Cited by 47 publications

(53 citation statements)

References 10 publications

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“…3. In previous papers, we demonstrated that a voltage gap measured in between the forward and backward current minima appears when biomolecules are immobilized onto the nanowire surface, and its changes are used for the detection of increasing concentrations of analytes [25,26]. In the present letter, we show that the memristive voltage gap variation also works for pH measurements.…”

Section: Ph Sensing In Airsupporting

confidence: 51%

“…In these structures, the memory effects depend on charge carrier rearrangement at the nanoscale as due to external perturbations [24]. Recently, very promising results have been reported on the use of the memristive behavior of SiNWs for sensing biological molecules in dry conditions [25,26], thus opening a promising new research line. These devices have been characterized [26,27] and demonstrated to feature the main fingerprints of a memristive system, such as the dynamic current-voltage curves of a pronounced double loop shape, the pinched hysteresis-loop, and its frequency-dependence [22].…”

Section: Introductionmentioning

confidence: 99%

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Memristive sensors for pH measure in dry conditions

et al. 2014

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Keywords:Memristive sensor Silicon nanowires pH sensing Hysteresis Measurements in air Conductivity in thin water film A large progress in pH sensing with nanowire based ion-sensitive field-effect transistors (ISFETs) has been demonstrated over the years. The electrochemical reactions occurring at the wire surface-to-electrolyte interface play a key role in the detection of ions. In this letter, we show that pH sensing can also be performed on dried samples, through electrical measurements in air with a new kind of memristive sensor. The detection of different concentrations of [H + ] is confirmed by both the increased conductance and hysteretic voltage gap of the wires. The observed change in the electrical properties with pH in dry conditions is related to the formation of a wet film at the nanowire surface. Ions from the initial solution are free to move in the final water thin film at the sensing interface with consequent polarization of the NW surface.

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Section: Ph Sensing In Airsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Memristive sensors for pH measure in dry conditions

et al. 2014

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“…When biological substances are present on the surface of the device the hysteresis appears shifted from zero to different voltage values, namely a voltage gap is introduced in the semi-logarithmic electrical characteristics, leading to a label-free bio-detection method [4], [5].…”

Section: A Experimental -Fabrication Methodologymentioning

confidence: 99%

“…Among the different applications that memristive effect had already been introduced, a further approach presuming upon the memristive behavior of bio-functionalized nanofabricated wires, so-called Memristive Biosensors, has been suggested for sensing biomolecules [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Resistance impact by long connections on electrical behavior of integrated Memristive Biosensors

Tzouvadaki

Vallero

Puppo

et al. 2016

2016 IEEE International Symposium on Circuits and Systems (ISCAS)

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Abstract-Integration of nanowire structures in more complex platforms combining microfluidics and multiplexing aspects may complex the electrical readout process. In the present work, fabrication of Aluminium (Al) lines for electrical connections is attempted followed by their integration to nanofabricated Memristive Biosensors that target at the labelfree detection of cancer biomarkers. In addition a computational study is carried out investigating the impact of the resistance introduced by the additional Al connections to the electrical response of the Memristive Biosensors. Overall, the present study explores the restrictions and the possibilities of the Memristive Biosensors' integration with additional elements that would allow effective readout in more complex configurations.

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“…Typically the currently developed SiNW biosensors require measurement with a probe station to monitor the conductance changes between source and drain electrodes induced by recognition event between target molecules and the surface-bound receptors. We have very recently introduced a completely novel approach based on the memristive effect in SiNWs [3], [4], [5], and have demonstrated great potentials for the ultra-high sensitive detection of biomarkers in air [6]. This method is based on charge effects of biomolecules on the so called voltage gap.…”

Section: Introductionmentioning

confidence: 99%

Novel readout circuit for memristive biosensors in cancer detection

Zaher

Häfliger

Puppo³

et al. 2014

2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings

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Abstract-We present a novel circuit for the automated and quick characterization of an array of experimental memristive nanowires that are functionalized as biosensors. Successfully functionalized nanowires will express the concentration of target molecules by hysteretic gaps of the zero crossing of their memristive I/V characteristics as the voltage across them is swept up and down. The width of the voltage gap is directly proportional to the target molecule concentration. The characterization circuit sorts out faulty, i.e. non-conducting nanowires in the array, and performs an analog to digital conversion of the voltage gap to assess successful functionalization of the others, and thus significantly reduces the time for functional testing. Many of the test parameters are configurable: the speed and range of the voltage sweep and the resolution of the measurements. An initial prototype 2x2 array of the circuit has been layed out in 0.35µm CMOS technology within an area of 0.429 mm 2 and has been thoroughly characterized in simulation, has been layed out, and is ready for fabrication.

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New Insight on Bio-sensing by Nano-fabricated Memristors

Cited by 47 publications

References 10 publications

Memristive sensors for pH measure in dry conditions

Memristive sensors for pH measure in dry conditions

Resistance impact by long connections on electrical behavior of integrated Memristive Biosensors

Novel readout circuit for memristive biosensors in cancer detection

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