New hybrid magnetic nanoparticles based on chitosan-maltose derivative for antitumor drug delivery

Alupei, Liana; Peptu, Cătălina Anişoara; Lungan, Andreea-Maria; Desbrières, Jacques; Chiscan, Ovidiu; Radji, Sadia; Popa, Marcel

doi:10.1016/j.ijbiomac.2016.07.058

Cited by 31 publications

(39 citation statements)

References 35 publications

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“…Current investigations have also synthesized IONPs employing different shells with anticancer agents conventionally administered, such as β-cyclodextrin [ 135 ], carmustine [ 136 ], cetuximab [ 137 , 138 , 139 ], cytarabine [ 140 ], daunomycin [ 141 ], docetaxel [ 142 , 143 ], epirubicin [ 144 ], 5-fluorouracil [ 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 ], gemcitabine [ 22 , 154 , 155 , 156 , 157 , 158 ], methotrexate [ 159 , 160 , 161 ], mitoxantrone [ 162 , 163 , 164 , 165 ] and paclitaxel [ 27 , 104 , 166 , 167 , 168 , 169 , 170 , 171 , 172 ]. It is noteworthy, however, that these nanosystems demonstrate magnetic properties only in the presence of external magnetic fields to prevent agglomerations of nanoparticles [ 111 ] and to allow a satisfactory performance in the target sites.…”

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

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Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.

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Section: Drugs Bound To Ionpsmentioning

confidence: 99%

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

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“…The production of hybrid constructs combining ferromagnetic elements, such as iron, nickel and cobalt, with ions, oxygen and other metals, such as noble metals, contributes to the development of new nano-sized structures with tuned properties for multimodal biomedical applications [44][45][46]. Hybrid MNPs production can be carried out through the various above-mentioned chemical synthesis methods.…”

Section: Hybrid Mnp Synthesismentioning

confidence: 99%

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

2020

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Technological development is in constant progress in the oncological field. The search for new concepts and strategies for improving cancer diagnosis, treatment and outcomes constitutes a necessary and continuous process, aiming at more specificity, efficiency, safety and better quality of life of the patients throughout the treatment. Nanotechnology embraces these purposes, offering a wide armamentarium of nanosized systems with the potential to incorporate both diagnosis and therapeutic features, towards real-time monitoring of cancer treatment. Within the nanotechnology field, magnetic nanosystems stand out as complex and promising nanoparticles with magnetic properties, that enable the use of these constructs for magnetic resonance imaging and thermal therapy purposes. Additionally, magnetic nanoparticles can be tailored for increased specificity and reduced toxicity, and functionalized with contrast, targeting and therapeutic agents, revealing great potential as multifunctional nanoplatforms for application in cancer theranostics. This review aims at providing a comprehensive description of the current designs, characterization techniques, synthesis methods, and the role of magnetic nanoparticles as promising nanotheranostic agents. A critical appraisal of the impact, potentialities and challenges associated with each technology is also presented.

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“…Among pH-sensitive artificial and natural polymers, chitosan (CS) and its derivatives have been used to functionalize MNPs because of their excellent biorelated properties. 8 , 21 , 23 , 29 For example, CS-functionalized mesoporous MNPs were reported for pH-responsive controlled release of an antineoplastic drug. 29 CS was employed for enhancing their biocompatibility and electrostatic loading capacity of the drug molecules.…”

Section: Introductionmentioning

confidence: 99%

“…Hybrid MNPs coated with maltose-modified CS (CS-Malt) were also reported for antitumor drug delivery. 21 Fe 3 O 4 particles were prepared by coprecipitation and coated with CS-Malt, followed by both ionic and covalent cross-linkage with Na 2 SO 4 and glutaraldehyde, respectively, in reverse emulsion.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Charge-Conversional and Hemolytic Activities of Magnetic Nanocomposite Particles for Cell-Targeted Hyperthermia

et al. 2018

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Magnetic nanocomposite particle (MNP)-induced hyperthermia therapy has been restricted by inefficient cellular targeting. pH-responsive charge-conversional MNPs can enhance selective cellular uptake in acidic cells like tumors by sensing extracellular acidity based on their charge alteration. We have synthesized new, pH-induced charge-conversional, superparamagnetic, and single-cored Fe3O4 nanocomposite particles coated by N-itaconylated chitosan (NICS) cross-linked with ethylene glycol diglycidyl ether (EGDE) (Fe3O4-NICS-EGDE) using a simple, one-step chemical coprecipitation–coating process. The surface of the Fe3O4-NICS-EGDE nanocomposite particles was modified with ethanolamine (EA) via aza-Michael addition to enhance their buffering capacity, aqueous stability, and pH sensitivity. The designed Fe3O4-NICS-EGDE-EA nanocomposite particles showed pH-dependent charge-conversional properties, colloidal stability, and excellent hemocompatibility in physiological media. By contrast, the charge-conversional properties enabled microwave-induced hemolysis only under weakly acidic conditions. Therefore, the composite particles are highly feasible for magnetically induced and targeted cellular thermotherapeutic applications.

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New hybrid magnetic nanoparticles based on chitosan-maltose derivative for antitumor drug delivery

Cited by 31 publications

References 35 publications

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

pH-Responsive Charge-Conversional and Hemolytic Activities of Magnetic Nanocomposite Particles for Cell-Targeted Hyperthermia

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