New global recommendations: A multidisciplinary approach to improving outcomes in diabetes

McGill, Margaret; Felton, Anne-Marie

doi:10.1016/j.pcd.2006.07.004

Cited by 65 publications

(56 citation statements)

References 31 publications

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“…T he achievement of an adequate glycemic control is crucial in preventing chronic complications in diabetes (1). Haemoglobin A1c (Hb A1c) is a marker of the average blood glucose levels in the past 90 days and is commonly used as a predictor of diabetic complications (2,3).…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation of haemoglobin A1c in a Portuguese adult population

Pereira

Lira

Bacelar

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospitalbased adult population over a period of 5 years. Materials and methods: We analyzed retrospectively monthly Hb A1c mean values (DCCT, %) based on all the assays performed to adult patients at a tertiary care university Portuguese hospital between 2008-2012. Results: We obtained 62,384 Hb A1c valid measurements, with a peak level found in January-February (7.1%), a trough in AugustOctober (6.8%) and an average peak-to-trough amplitude value of 0.3%. This trend was observed in both genders and age subgroups evaluated. Conclusions: There is a Hb A1c circannual seasonal pattern with peak levels occurring in winter months in this Portuguese population. This finding should be recognized in daily clinical practice to warrant better clinical and epidemiological interpretation of Hb A1c values. Arch Endocrinol Metab. 2015;59(3):231-5

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Section: Introductionmentioning

confidence: 99%

Seasonal variation of haemoglobin A1c in a Portuguese adult population

Pereira

Lira

Bacelar

et al. 2015

Arch. Endocrinol. Metab.

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“…As a consequence of suboptimal glycemic management and delays in treatment intensification or modification, the complications of T2DM resulting from chronic hyperglycemia continue to cause substantial morbidity and mortality [22,27]. Clearly, intensive blood glucose lowering therapy should be employed to reach and maintain the most appropriate HbA1c value in each individual while always considering safety.…”

Section: Introductionmentioning

confidence: 99%

Treatment urgency: The importance of getting people with type 2 diabetes to target promptly

Felton

LaSalle

McGill

2016

Diabetes Research and Clinical Practice

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“…Some complications such as cardiovascular disease, kidney disease, retinopathy, and nervous system diseases result in substantial morbidity and mortality. 2 Diabetic nephropathy is a progressive, irreversible disease characterized by increasing blood pressure, micro albuminuria, proteinuria, and a continuous decline in glomerular filtration rate. There are several factors involved in the development of diabetic glomerulopathy but the main initiator of this disease is chronic hyperglycemia, which triggers increased production of reactive oxygen species, increasing oxidative stress and favoring coagulation and fibrotic events.…”

Section: Introductionmentioning

confidence: 99%

Effect of compounds isolated from Filicium decipiens and Ventilago madraspatana against diabetic nephropathy in streptozotocin induced diabetic rats

Sasikala¹,

Sudhakar²

2015

IJPER

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Context: Diabetes mellitus is a group of syndromes characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. Filicum decipiens Wight & Arn., (Sapindaceae) and Ventilago madraspatana Gaertn., (Rhamnaceae) are traditionally used for diabetic and other different folk medical uses. Objective: The present study compares the antihperglycemic activity exerted by methanolic extracts of Filicum decipiens (400 mg/kg), Ventilago madraspatana (400 mg/kg), rutin (100 mg/kg), quercetin (50 mg/kg) and combined treatment of rutin with quercetin (100 mg/kg+ (50 mg/kg) on diabetic rats. Material and methods: Methanolic extracts of Filicum decipiens and Ventilago madraspatana leaves were prepared and isolated by soxhlet and solubilization method. Rats were made diabetic by a single dose of streptozotocin (45 mg/kg i.p.). The animals with fasting blood glucose level more than 250 mg/dL were given methanolic leaves extract of Filicum decipiens (400 mg/kg), Ventilago madraspatana (400 mg/kg), quercetin (50 mg/kg), rutin (100 mg/kg) and rutin with quercetin (100 mg/kg + 50 mg/kg) were administered for 45 days and screened for antidiabetic activity. Results and discussion: After 45 days we observed that supplementation with combined dose of rutin and quercetin significantly (p<0.05) decreased glycosylated hemoglobin (HbA 1 C) (6.01 mg/g ) and increased the levels of plasma insulin 11.98 μU/mL, hemoglobin 12.12 g/dL, urea 42.16 mg/dL, creatinine 1.41 mg/dL, plasma sodium141.00 mEq/L and urinary potassium 5.11 mEq/L and decrease the activities of enzymatic antioxidant upon STZ treatment and also significantly (p<0.05) reversed the altered levels and activities of above mentioned diabetic, renal and antioxidant markers in experimental rats as compared to their individual supplementation. Conclusion: Summed effect of quercetin with rutin seems to have a promising value for the development of a potent phytomedicine for diabetic nephropathy.

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New global recommendations: A multidisciplinary approach to improving outcomes in diabetes

Cited by 65 publications

References 31 publications

Seasonal variation of haemoglobin A1c in a Portuguese adult population

Seasonal variation of haemoglobin A1c in a Portuguese adult population

Treatment urgency: The importance of getting people with type 2 diabetes to target promptly

Effect of compounds isolated from Filicium decipiens and Ventilago madraspatana against diabetic nephropathy in streptozotocin induced diabetic rats

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