Seasonal variation of haemoglobin A1c in a Portuguese adult population

Pereira, Maria Teresa; Lira, Domingos; Bacelar, Conceição; Oliveira, José Carlos; Carvalho, André

doi:10.1590/2359-3997000000043

Cited by 19 publications

(24 citation statements)

References 34 publications

(45 reference statements)

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“…2 These crises should be preventable with education of patients and healthcare professionals (HCPs). However, studies show significantly poor knowledge in both groups, 3,4 leading to failure to increase…”

Section: Poor Knowledge Of Safety Aspects Of Long-term Steroid Use Ammentioning

confidence: 99%

“…[1][2][3][4] Potential susceptibilities to seasonal change of HbA1c include inappropriate dietary calorie intake and insufficient physical activity in winter. In our hospital, the majority of diabetes patients are farmers and their physical activity is relatively lower in winter (agricultural off-season) than in summer (busy farming season).…”

Section: Sodium Glucose Co-transporter 2 Inhibitors Successfully Attementioning

confidence: 99%

“…[1][2][3][4] If these patients are then administered excess amounts of either endogenous or exogenous insulin without correcting their excess caloric intake and/or improving their decreased physical activity, they will experience inappropriate body weight gain although their blood glucose control may be improved. In this study, we added SGLT2 inhibitors to the patients' current medication and observed whether SGLT2 inhibitor administration could attenuate the tendency for HbA1c to get worse towards winter season.…”

Section: Sodium Glucose Co-transporter 2 Inhibitors Successfully Attementioning

confidence: 99%

“…3 This letter sets out to summarise the ethical arguments that underpin the BMA guidance, illustrate how this guidance could be put into practice and raise debate on this issue.…”

mentioning

confidence: 99%

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Sodium glucose co-transporter 2 inhibitors successfully attenuated seasonal change of glycated haemoglobin A1c

et al. 2017

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Section: Poor Knowledge Of Safety Aspects Of Long-term Steroid Use Ammentioning

confidence: 99%

Section: Sodium Glucose Co-transporter 2 Inhibitors Successfully Attementioning

confidence: 99%

Section: Sodium Glucose Co-transporter 2 Inhibitors Successfully Attementioning

confidence: 99%

“…3 This letter sets out to summarise the ethical arguments that underpin the BMA guidance, illustrate how this guidance could be put into practice and raise debate on this issue.…”

mentioning

confidence: 99%

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Sodium glucose co-transporter 2 inhibitors successfully attenuated seasonal change of glycated haemoglobin A1c

et al. 2017

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“…In the treatment of patients with type 2 diabetes mellitus, it is important to lower the blood glucose level and keep the value constant. However, many reports have stated that hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus fluctuate throughout the year. Surveys in Japanese patients showed that the level generally increased in winter and decreased from summer to autumn.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the effect of seasonal administration on the efficacy of sitagliptin: Subanalysis of the Januvia Multicenter Prospective Trial in Type 2 Diabetes Study

Sakura

Hashimoto

Sasamoto

et al. 2018

J of Diabetes Invest

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Aims/IntroductionHemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus fluctuate throughout the year. However, there are few studies that have evaluated the therapeutic effect of hypoglycemic agents while considering such fluctuations. In a multicenter study (Januvia Multicenter Prospective Trial in Type 2 Diabetes Study), pretreatment patients with type 2 diabetes mellitus were divided into seven groups and given sitagliptin for 1 year. The aim of the present study was to evaluate the differences in the therapeutic effect, and the efficacy of sitagliptin in patients with type 2 diabetes mellitus based on the month the administration of the drug began as a subanalysis of the Januvia Multicenter Prospective Trial in Type 2 Diabetes Study.Materials and MethodsPatients with type 2 diabetes mellitus were divided into four groups according to the month of initiation of sitagliptin. Changes in HbA1c in each group were compared at 3 and 12 months after administration of sitagliptin. As a negative correlation has been reported between baseline HbA1c and the degree of change after administration of sitagliptin, an analysis using the residual error from the approximate line was carried out.ResultsIn the analysis of the degree of change in HbA1c, patients in the group in which administration of sitagliptin was started between August and October had the lowest degree of improvement at 3 months after starting sitagliptin. However, there was no significant intergroup difference in improvement at 12 months after the start of sitagliptin. The same result was also obtained in residual analysis.ConclusionsThe present study suggested that the season of administration of sitagliptin influenced the subsequent hypoglycemic effect even after analysis excluding the influence of HbA1c value at the start of treatment. This study provides possibility, showing that seasonal fluctuations have an effect on the efficacy of antidiabetic drugs.

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Study on the effects of changes in lifestyle of patients with diabetes on glycaemic control before and after the declaration of the state of emergency in Japan

Masuda¹,

Takahashi²

2021

Diabetol Int

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Objective To investigate the actual conditions of changes in lifestyle and treatment status of patients with diabetes before and after the declaration of the state of emergency issued in response to the novel coronavirus. Methods This study was a collaborative study in two diabetes clinics. A total of 1000 subjects responded to the questionnaire. In addition, data on HbA1c and body weight before and after the declaration of the state of emergency were collected. Results HbA1c levels significantly decreased from 7.28 ± 0.97% before the declaration of the state of emergency to 7.07 ± 0.86% after the declaration ( p < 0.001). A significant decrease in HbA1c levels was also noted in both T2DM and T1DM. A factorial analysis of the change in HbA1c levels found that a high HbA1c level before the declaration was the most influential factor that made the HbA1c level more likely to decrease, with such factors including a good amount of exercise. A positive correlation with change in body weight was noted. Factors that made the HbA1c level less likely to decrease included stress felt about school closures for children, increased opportunities to eat out, increased food consumption, and refraining from exercise to avoid the “Three Cs” (crowded places, close-contact settings, and confined and enclosed spaces). Conclusion In the absence of serious economic stagnation or completely disrupted distribution, patients are allowed time to do what they like and can probably improve their glycaemic control status if they see this time as an opportunity. Supplementary Information The online version contains supplementary material available at 10.1007/s13340-021-00505-6.

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Seasonal variation of haemoglobin A1c in a Portuguese adult population

Cited by 19 publications

References 34 publications

Sodium glucose co-transporter 2 inhibitors successfully attenuated seasonal change of glycated haemoglobin A1c

Sodium glucose co-transporter 2 inhibitors successfully attenuated seasonal change of glycated haemoglobin A1c

Analysis of the effect of seasonal administration on the efficacy of sitagliptin: Subanalysis of the Januvia Multicenter Prospective Trial in Type 2 Diabetes Study

Study on the effects of changes in lifestyle of patients with diabetes on glycaemic control before and after the declaration of the state of emergency in Japan

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