New evidence on the health hazards and control of metalworking fluids since completion of the OSHA advisory committee report

Mirer, Franklin E.

doi:10.1002/ajim.20853

Cited by 37 publications

(22 citation statements)

References 95 publications

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“…There has been some indication of an increased risk of total leukaemia and CLL among individuals involved in metal working occupations in previous studies 3 11 28 29. Consistently, in our study an increased risk of lymphoid leukaemias and CLL (data not shown) was found for turning/metal engineering.…”

Section: Discussionsupporting

confidence: 92%

Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

et al. 2013

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Section: Discussionsupporting

confidence: 92%

Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

et al. 2013

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“…The main task of more susceptible to biocides when compared to bacteria and fungi inhabiting the biofilms in these settings. There is no possibility of eradication (complete elimination) of biofilms and this leads to a phenomenon (often observed in practice) of rapid re-growth of microorganisms population after cleaning and disinfection of MWF tanks and circulation systems [2,3]. In the European Union, the regulations regarding the permissible level of microbial contamination in MWFs have not been yet established.…”

Section: Introductionmentioning

confidence: 99%

Microorganisms in metalworking fluids: Current issues in research and management

Trafny¹

2013

International Journal of Occupational Medicine and Environmental Health

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The microbial contamination of water miscible metalworking fluids (MWFs) is a serious problem in metal industry. A good maintenance of MWF re-circulation systems can extend the lifetime of coolants and ensure the quality of the tools produced. In MWFs, as in the other water-based environments, microorganisms usually live in the form of biofilms, the communities of bacteria and fungi attached to the surface of sumps, metal parts and also to each other. Biofilms exhibit very high resistance to biocides. The effect of biocides that are used as additives to MWFs to control the growth of the bacterial and fungal microbiomes (microorganisms characteristic to the individual coolant system) have become the subject of research only in recent years. There are also only sparse reports on the impact of biocides on microorganisms growing in biofilms in MWF installations. Fast growing mycobacteria are important members of these biofilm communities. Their presence has recently been linked with the occurrence of cases of hypersensitivity pneumonitis, a serious respiratory disorder in the metal industry employees. The new, relatively fast and inexpensive techniques to assess the species diversity within MWF microbiomes and their population size should be developed in order to control the microorganisms' proliferation in MWFs and to diminish the occupational exposure to harmful bioaerosols in metal industry.

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“…The GM-UAW cohort has been recognized for its quantitative exposure assessment of metalworking fluids by type. 610 Other strengths of this cohort include the diversity of the cohort and its size, as well as the length and completeness of the follow-up (less than 4% loss to follow up).…”

Section: Discussionmentioning

confidence: 99%

“…8–11 Straight MWF contain polycyclic aromatic hydrocarbons (PAHs), which can react with DNA molecules, potentially forming adducts that, if not repaired, can lead to mutations following cellular replication and, eventually, clinically apparent cancer. 68–10 Also, in straight MWF, N-nitrosodiethanolamine 12 can form. This byproduct of nitrite and amine additives is carcinogenic in animal models 13 and may have similar potential in humans.…”

Section: Introductionmentioning

confidence: 99%

Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers

et al. 2016

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Objectives Metalworking fluids (MWF), used to cool and lubricate metal in occupational settings, are linked to several cancers but data on kidney cancer are limited. We examine how MWF influence the rate of renal cell carcinoma (RCC) in a large prospective study. Methods A cohort of Michigan autoworkers consisting of 33,421 individuals was followed 1985 through 2009. The cohort was linked to the Michigan Cancer Registry to identify new cases of RCC. We analyzed RCC in relation to cumulative exposure to each specific type of MWF (straight, soluble and synthetic) and all three types pooled into a single MWF variable, with a 15-year lag. Cox Proportional Hazards Regression with splines were used to estimate Hazard Ratios (HRs) and 95% confidence intervals (95% CIs), controlling for age, gender, race, calendar year, year hired, time since hire, plant, and other MWF types. Results There were 135 incident cases. A linear increase in the log-HR was observed for RCC with increasing cumulative exposure to each MWF type and total MWF exposure. At the mean of total MWF exposure (18.80 mg/m3-yr), the estimated HR was 1.11 (95% CI 1.04, 1.19). Conclusions Our results provide evidence for a dose-dependent association between MWF exposure and RCC. The influence of components of both oil- and water-based MWF needs further examination.

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New evidence on the health hazards and control of metalworking fluids since completion of the OSHA advisory committee report

Abstract: Material new evidence demonstrates significant risks to material impairment of health at prevailing exposure levels and feasibility of lower exposure limits.

Cited by 37 publications

References 95 publications

Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Microorganisms in metalworking fluids: Current issues in research and management

Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers

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