Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers

Shrestha, Deepika; Liu, Sa; Hammond, S. Katharine; LaValley, Michael P.; Weiner, Daniel E.; Eisen, Ellen A.; Applebaum, Katie M.

doi:10.1136/oemed-2016-103769

Cited by 8 publications

(3 citation statements)

References 44 publications

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“…Another cohort study on the effect of metalworking fluids as RCC risk factor which recruited 33,421 workers also found that there were only 13.5% of female workers. Both 2,4,5-T herbicide and metalworking fluids exposures were shown to be associated with increased risk for RCC (Andreotti et al, 2020;Shrestha et al, 2016).…”

Section: Discussionmentioning

confidence: 98%

Clinicopathologic Characteristics of Renal Cell Carcinoma in Prof. dr. I.G.N.G. Ngoerah General Hospital 2018 – 2022

Junior,

Winarti,

Sriwidyani

et al. 2023

RSD

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RCC is a tumor that manifests in proximal tubule epithelial cells and accounts for 3% of total adult neoplastic cases. In Indonesia, RCC cases are still deemed low, but show a tendency to increase annually. This study’s objective is to provide a description on the clinicopathologic features of RCC patients in Prof. dr. I.G.N.G. Ngoerah General Hospital in the province of Bali from 2018 to 2022. This is a cross-sectional study which implemented total sampling in collecting secondary data from the laboratory of anatomical pathology in Prof. dr. I.G.N.G. Ngoerah General Hospital. There were 38 cases of RCC from a total of 108 kidney cases which underwent histopathologic examinations. Descriptive analysis showed that the majority of RCC cases were found in the age range of 51 – 60 years old (36.8%), males (76,3%), left tumor laterality (57,9%), operative procedures for specimen collection (94,7%), ccRCC subtype (63,2%), tumor size of >10 cm (50,0%), grade III – IV (57,9%), and pT3a stage (47,4%). The combination of these clinicopathologic findings suggested that the RCC patients in Bali were shown to be associated with worse prognosis and should consider further analytical studies.

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Section: Discussionmentioning

confidence: 98%

Clinicopathologic Characteristics of Renal Cell Carcinoma in Prof. dr. I.G.N.G. Ngoerah General Hospital 2018 – 2022

Junior,

Winarti,

Sriwidyani

et al. 2023

RSD

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“…The authors enrolled 57,310 individuals seeking licenses to apply for restricted-use pesticides in Iowa and North Carolina between 1993 and 1997, of whom only about 2.7% were female [29]. Similarly, in a study presenting a dose-dependent association between RCC and exposure to metalworking fluids among autoworkers, the cohort consisted of 33,421 individuals, of whom 86.5% were males [30].…”

Section: Smoking and Occupational Hazardmentioning

confidence: 99%

Sex and Gender Differences in Kidney Cancer: Clinical and Experimental Evidence

Peired

Campi

Angelotti

et al. 2021

Cancers

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Sex and gender disparities have been reported for different types of non-reproductive cancers. Males are two times more likely to develop kidney cancer than females and have a higher death rate. These differences can be explained by looking at genetics and genomics, as well as other risk factors such as hypertension and obesity, lifestyle, and female sex hormones. Examination of the hormonal signaling pathways bring further insights into sex-related differences. Sex and gender-based disparities can be observed at the diagnostic, histological and treatment levels, leading to significant outcome difference. This review summarizes the current knowledge about sex and gender-related differences in the clinical presentation of patients with kidney cancer and the possible biological mechanisms that could explain these observations. Underlying sex-based differences may contribute to the development of sex-specific prognostic and diagnostic tools and the improvement of personalized therapies.

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“…Although studies on occupational exposure limits for MWF have been published [ 8 , 9 ], there are no set thresholds for cumulative exposure. Shrestha et al have supposed that long-term exposure to MWF aerosols correlates with kidney cancer and glomerulonephritis [ 10 , 11 ]. According to previous research, MWF aerosols contain sulfonates, nonionic surfactants, ethanolamine, medium-chained chlorinated paraffins (MCCPs), and polycyclic aromatic hydrocarbons (PAHs) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Association between exposure to metalworking fluid aerosols, occupational noise and chronic kidney disease: a cross-sectional study in China

Zhou,

Wu,

Tang

et al. 2024

BMC Public Health

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Background Chronic kidney disease (CKD) carries a high public health burden yet little is known about the relationship between metalworking fluid (MWF) aerosols, occupational noise and CKD. We aimed to explore the relationship between occupational MWF aerosols, occupational noise and CKD. Methods A total of 2,738 machinists were sampled from three machining companies in Wuxi, China, in 2022. We used the National Institute for Occupational Safety and Health (NIOSH) method 5524 to collect individual samples for MWF aerosols exposure, and the Chinese national standard (GBZ/T 189.8–2007) method to test individual occupational noise exposure. The diagnostic criteria for CKD were urinary albumin/creatinine ratio (UACR) of ≥ 30 mg/g and reduced renal function (eGFR < 60 mL.min− 1. 1.73 m− 2) lasting longer than 3 months. Smooth curve fitting was conducted to analyze the associations of MWF aerosols and occupational noise with CKD. A segmented regression model was used to analyze the threshold effects. Results Workers exposed to MWF aerosols (odds ratio [OR] = 2.03, 95% confidence interval [CI]: 1.21–3.41) and occupational noise (OR = 1.77, 95%CI: 1.06–2.96) had higher prevalence of CKD than nonexposed workers. A nonlinear and positive association was found between increasing MWF aerosols and occupational noise dose and the risk of CKD. When daily cumulative exposure dose of MWF aerosols exceeded 8.03 mg/m3, the OR was 1.24 (95%CI: 1.03–1.58), and when occupational noise exceeded 87.22 dB(A), the OR was 1.16 (95%CI: 1.04–1.20). In the interactive analysis between MWF aerosols and occupational noise, the workers exposed to both MWF aerosols (cumulative exposure ≥ 8.03 mg/m3-day) and occupational noise (LEX,8 h ≥ 87.22 dB(A)) had an increased prevalence of CKD (OR = 2.71, 95%CI: 1.48–4.96). MWF aerosols and occupational noise had a positive interaction in prevalence of CKD. Conclusions Occupational MWF aerosols and noise were positively and nonlinearly associated with CKD, and cumulative MWF aerosols and noise exposure showed a positive interaction with CKD. These findings emphasize the importance of assessing kidney function of workers exposed to MWF aerosols and occupational noise. Prospective and longitudinal cohort studies are necessary to elucidate the causality of these associations.

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Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers

Cited by 8 publications

References 44 publications

Clinicopathologic Characteristics of Renal Cell Carcinoma in Prof. dr. I.G.N.G. Ngoerah General Hospital 2018 – 2022

Clinicopathologic Characteristics of Renal Cell Carcinoma in Prof. dr. I.G.N.G. Ngoerah General Hospital 2018 – 2022

Sex and Gender Differences in Kidney Cancer: Clinical and Experimental Evidence

Association between exposure to metalworking fluid aerosols, occupational noise and chronic kidney disease: a cross-sectional study in China

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