New Composite Nanomaterials with Antimicrobial and Photocatalytic Properties Based on Silver and Zinc Oxide

Dumbravă, Anca; Berger, Daniela; Matei, Cristian; Prodan, G.; Aonofriesei, Florin; Radu, Marius; Moscalu, Florin

doi:10.1007/s10904-019-01166-4

Cited by 21 publications

(9 citation statements)

References 48 publications

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“…Antiviral studies were also performed, but these materials did not present significant viral reduction.Nanomaterials 2020, 10, 503 2 of 14 antimicrobial nanostructures are one of the most promising alternatives in the search for new antimicrobial substances [3][4][5]. The attention has been principally centered on metallic/metal oxide nanoparticles due to their broad antibacterial and antifungal activities at low concentrations thanks to their high specific area [6][7][8][9].Zinc oxide (ZnO) nanoparticles are an inorganic material with optical, chemical sensing, electric conductivity, catalytic, photochemical, and antimicrobial properties. This metal oxide presents three crystal structures: wurtzite, zinc blend, and rocksalt, with a direct wide band gap of 3.3 Ev [10].…”

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confidence: 99%

“…Nanomaterials 2020, 10, 503 2 of 14 antimicrobial nanostructures are one of the most promising alternatives in the search for new antimicrobial substances [3][4][5]. The attention has been principally centered on metallic/metal oxide nanoparticles due to their broad antibacterial and antifungal activities at low concentrations thanks to their high specific area [6][7][8][9].…”

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confidence: 99%

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Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

et al. 2020

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An antimicrobial polymeric bilayer structure based on the application of an acrylic coating containing hollow zinc oxide nanotubes over a polymeric substrate was developed in this work. Firstly, zinc oxide nanotubes (ZnO NT ) were obtained by an atomic layer deposition (ALD) process over electrospun polyvinyl alcohol nanofibers followed by polymer removal through calcination with the purpose of obtaining antimicrobial nanostructures with a high specific area. Parameters of electrospinning, ALD, and calcination processes were set in order to obtain successfully hollow zinc oxide nanotubes. Morphological studies through scanning electron microscopy (SEM) and transmission electron microscopy (TEM) microscopies confirmed the morphological structure of ZnO NT with an average diameter of 180 nm and thickness of approximately 60 nm. Thermal and X-ray diffraction (XRD) analyses provided evidence that calcination completely removed the polymer, resulting in a crystalline hexagonal wurtzite structure. Subsequently, ZnO NT were incorporated into a polymeric coating over a polyethylene extruded film at two concentrations: 0.5 and 1 wt. % with respect to the polymer weight. An antimicrobial analysis of developed antimicrobial materials was performed following JIS Z2801 against Staphylococcus aureus and Escherichia coli. When compared to active materials containing commercial ZnO nanoparticles, materials containing ZnO NT presented higher microbial inhibition principally against Gram-negative bacteria, whose reduction was total for films containing 1 wt. % ZnO NT . Antiviral studies were also performed, but these materials did not present significant viral reduction.Nanomaterials 2020, 10, 503 2 of 14 antimicrobial nanostructures are one of the most promising alternatives in the search for new antimicrobial substances [3][4][5]. The attention has been principally centered on metallic/metal oxide nanoparticles due to their broad antibacterial and antifungal activities at low concentrations thanks to their high specific area [6][7][8][9].Zinc oxide (ZnO) nanoparticles are an inorganic material with optical, chemical sensing, electric conductivity, catalytic, photochemical, and antimicrobial properties. This metal oxide presents three crystal structures: wurtzite, zinc blend, and rocksalt, with a direct wide band gap of 3.3 Ev [10]. Some works have evidenced ZnO nanoparticles with dimensions smaller than 100 nm have shown increasing antimicrobial properties against Gram-negative and Gram-positive bacteria due to a higher cellular internalization. Specifically, Verma et al. (2018) studies have indicated that the antibacterial activity of ZnO nanoparticles against Staphylococcus aureus and Escherichia coli increased with the decrease in their size from 250 to 80, 40, and 20 nm due to an increased reactive oxygen species generation and membrane damage in bacteria [11,12]. Different synthesis methods as sol-gel, hydrothermal, simple thermal sublimation, vapor-liquid-solid, double-jet precipitation, self-combustion, and "green synthes...

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Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

et al. 2020

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“…Silver nanoparticles have been considered one of the most interesting antimicrobial metallic NPs due to their high efficiency against bacteria, fungi, and viruses. Their high antimicrobial activity enables use in pharmaceutical, food, fabric, and packaging industries [ 97 – 99 ]. Nanda et al (2018) obtained Ag NPs through green synthesis methods by using different extracts of the fungus Aspergillus tamarri and AgNO 3 .…”

Section: Reviewmentioning

confidence: 99%

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Correa

Martínez

Vidal

et al. 2020

Beilstein J. Nanotechnol.

106

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The investigation of novel nanoparticles with antimicrobial activity has grown in recent years due to the increased incidence of nosocomial infections occurring during hospitalization and food poisoning derived from foodborne pathogens. Antimicrobial agents are necessary in various fields in which biological contamination occurs. For example, in food packaging they are used to control food contamination by microbes, in the medical field the microbial agents are important for reducing the risk of contamination in invasive and routine interventions, and in the textile industry, they can limit the growth of microorganisms due to sweat. The combination of nanotechnology with materials that have an intrinsic antimicrobial activity can result in the development of novel antimicrobial substances. Specifically, metal-based nanoparticles have attracted much interest due to their broad effectiveness against pathogenic microorganisms due to their high surface area and high reactivity. The aim of this review was to explore the state-of-the-art in metal-based nanoparticles, focusing on their synthesis methods, types, and their antimicrobial action. Different techniques used to synthesize metal-based nanoparticles were discussed, including chemical and physical methods and “green synthesis” methods that are free of chemical agents. Although the most studied nanoparticles with antimicrobial properties are metallic or metal-oxide nanoparticles, other types of nanoparticles, such as superparamagnetic iron-oxide nanoparticles and silica-releasing systems also exhibit antimicrobial properties. Finally, since the quantification and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review.

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“…Recent studies have proved the effectiveness of nanoparticle-based drugs use, as the nanostructured particles ensure an equal increase in drug concentration in blood and tissues, even deeply penetrating body's natural barriers such as skin and blood-brain barriers, producing high drug dose in lesions, providing an optimal therapeutic effect, and having a powerful antibacterial, bacteriostatic and antiviral effect. Silver-based drugs do not cause resistance with the majority of pathogens, they are low-toxic, hypoallergenic, and also have immunocorrecting properties [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…The perspective of the development and the medical use of substances containing zinc oxide nanoparticles, the preparations whereof have high antibacterial and photocatalytic properties, is of considerable interest [5,6]. There is fragmentary information about zinc nanoparticles producing anti-sclerotic effect, i.e.…”

Section: Introductionmentioning

confidence: 99%

Local treatment of burn wounds in animals using a new nanocomponent ointment

et al. 2019

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We have developed an ointment preparation consisting of silver and zinc oxide nanoparticles, which form the basis of the nanocomposition. This drug can reduce the healing time of the wound surface due to the inclusion of nanodispersed particles in the composition. Application of nanoparticles allows to reduce inflammatory process, to carry out disinfecting treatment of a wound surface from pathogenic microorganisms, and accordingly to create optimum conditions for reparative process. Nanocomposite preparation has many advantages over existing analogues without irritating and allergic effects. Due to the high adsorption capacity, it allows to accelerate the healing process of the damaged surface of the skin. Initial studies were conducted on laboratory rats at the age of 6 months with a close mass that was up to 250 g in accordance with international requirements for the use of laboratory animals. As a result of the experiment, a new ointment preparation based on silver and zinc oxide nanoparticles, which are active components of the nanocomposition, was obtained. The use of these components allowed to accelerate the process of reparative restoration of the skin with full recovery of the studied animals. As shown by the experience, the recovery rate on average accelerated by seven days, compared with similar drugs available on the pharmaceutical market.

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New Composite Nanomaterials with Antimicrobial and Photocatalytic Properties Based on Silver and Zinc Oxide

Cited by 21 publications

References 48 publications

Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Local treatment of burn wounds in animals using a new nanocomponent ointment

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