Local treatment of burn wounds in animals using a new nanocomponent ointment

Abstract

We have developed an ointment preparation consisting of silver and zinc oxide nanoparticles, which form the basis of the nanocomposition. This drug can reduce the healing time of the wound surface due to the inclusion of nanodispersed particles in the composition. Application of nanoparticles allows to reduce inflammatory process, to carry out disinfecting treatment of a wound surface from pathogenic microorganisms, and accordingly to create optimum conditions for reparative process. Nanocomposite preparation has many advantages over existing analogues without irritating and allergic effects. Due to the high adsorption capacity, it allows to accelerate the healing process of the damaged surface of the skin. Initial studies were conducted on laboratory rats at the age of 6 months with a close mass that was up to 250 g in accordance with international requirements for the use of laboratory animals. As a result of the experiment, a new ointment preparation based on silver and zinc oxide nanoparticles, which are active components of the nanocomposition, was obtained. The use of these components allowed to accelerate the process of reparative restoration of the skin with full recovery of the studied animals. As shown by the experience, the recovery rate on average accelerated by seven days, compared with similar drugs available on the pharmaceutical market.

Electrochemical Sensors Based on Noble Metal Nanoparticles in Voltammetry

“…AgNPs obtained by the borohydride citrate technique have a spherical shape (Fig. 1b), which are used for many purposes [4,5]. AgNPs obtained using the citrate technique (Fig.…”

Morphology of Coniophora eremophila Exposed to Silver and Zinc Oxide Nanoparticles in Dextrose Sabouraud Agar Analyzed by Scanning Electron Microscopy

“…Coniophora eremophila is a wood pathogen that has been studied as a model for antifungal components such as zinc oxide (ZnONP) and silver (AgNP) nanoparticles [Arzate et al, 2017]. Zinc oxide is a well known antifungal agent used in ointments [Fedota et al, 2019], and silver is a wide range antimicrobial [Sim et al, 2018] with high toxicity that had been been tested against bacteria and fungi of clinical importance, however, not much is known about their effect on Coniophora species.…”