New biocompatible amphiphilic diblock copolymer based on dextran

Stanciu, Magdalena Cristina; Nichifor, Marieta

doi:10.1016/j.eurpolymj.2015.08.011

Cited by 8 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the introduction of acid-labile acetal groups, Fréchet and co-workers extended the application of dextran from a hydrophilic to a hydrophobic polysaccharide building block and incorporated a pH-responsive solubility switch. , Acetalated dextran (AcDex) has been studied extensively as a biopolymer material with pH sensitivity for the delivery of hydrophobic or hydrophilic , payloads in emulsion-based nanoparticle formulations. However, despite its utility, the use of AcDex as a stimulus-responsive hydrophobic building block for alternative polymer architectures has to date only been reported a few times. , Reported examples using dextran as a material for block copolymers applied the polysaccharide either for the hydrophilic − or the hydrophobic − block but so far not for both blocks at the same time.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

2017

View full text Add to dashboard Cite

A full polysaccharide amphiphilic block copolymer was prepared from end group-functionalized dextrans using copper-mediated azide-alkyne click chemistry. Sufficient modification of the reducing end in both blocks was achieved by microwave-enhanced reductive amination in a borate-buffer/methanol solvent system. The combination of a hydrophilic dextran block with a hydrophobic acetalated dextran block results in an amphiphilic structure that turns water-soluble upon acid treatment. The material has a low critical micelle concentration and self-assembles in water to spherical micellar nanoparticles. The formed nanoparticles have a narrow size distribution below 70 nm in diameter and disassemble in slightly acidic conditions. The amphiphilic polysaccharide system shows low toxicity and can stabilize the hydrophobic model drug curcumin in aqueous solutions over extended time periods.

show abstract

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

2017

View full text Add to dashboard Cite

show abstract

Preparation of dextran cryogels for separation processes of binary dye and pesticide mixtures from aqueous solutions

Ari

Yetiskin

Okay

et al. 2020

Polymer Engineering & Sci

View full text Add to dashboard Cite

We present mechanically strong macroporous, squeezable dextran cryogels as a column filling material for the removal and separation of binary organic dye and pesticide mixtures from aquatic medium. Dextran cryogels were prepared from aqueous solutions of dextran of various molecular weights (MWs) in the presence of 20 to 50 mol% divinyl sulfone (DVS) as a cross‐linker at −18°C. The cryogels have interconnected irregular pores of 100 μm in sizes, and exhibit 69‐84% reversible squeezability without damaging the 3D dextran network. Their total open pore volumes (6.3‐10 mL g−1), weight swelling ratios in water (1380%‐2200%), and mechanical parameters could easily be adjusted by both DVS mol% and MW of dextran. Dextran cryogel with the highest modulus (3.8 ± 0.5 MPa), compressive stress (8 ± 2 MPa) and plateau stress (0.46 ± 0.04 MPa) was obtained at 50 mol% DVS using dextran with a MW of 15 to 25 kg·mol−1. Dextran cryogels are hydrolysable at pH = 1 and 9 but stable at 7.4 independent on both the degree of cross‐linking and MW of dextran. At below 50 mol% DVS, they are blood compatible and possess slight thrombogenic effect with blood clotting index value of 98% ± 5%. They are also capable to separate binary dye and pesticide mixtures from aqueous solutions via ionic interactions.

show abstract

Dextran derivatives application as flocculants

Ghimici¹,

Nichifor²

2018

Carbohydrate Polymers

View full text Add to dashboard Cite

New biocompatible amphiphilic diblock copolymer based on dextran

Cited by 8 publications

References 44 publications

Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

Preparation of dextran cryogels for separation processes of binary dye and pesticide mixtures from aqueous solutions

Dextran derivatives application as flocculants

Contact Info

Product

Resources

About