Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

Breitenbach, Benjamin; Schmid, Ira; Wich, Peter

doi:10.1021/acs.biomac.7b00771

Cited by 54 publications

(59 citation statements)

References 67 publications

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“…applications (Breitenbach et al, 2017). Loureiro et al described the use of the high pressure homogenization method to produce P407-based nanoparticles with suitable properties for therapeutic applications (Loureiro et al, 2018).…”

Section: Production and Characterization Of The P407-based Nanoparticlesmentioning

confidence: 99%

Poloxamer 407 based-nanoparticles for controlled release of methotrexate

Moura

Noro

Cerqueira

et al. 2020

International Journal of Pharmaceutics

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Poloxamer 407 (P407)-based nanoparticles were produced by the high pressure homogenization method for the encapsulation and delivery of methotrexate (MTX), aiming intravenous therapeutic applications. The surface of these nanoparticles was functionalized by conjugation of P407 with folic acid (FA) or with MTX, which served as targeting ligand agents. MTX-P407 conjugate was also developed to increase the final drug cargo. Two hydrophobic derivatives of MTX, MTX di-ethylated ester (MTX-OEt) and the ionic complex MTX-dimethyldioctadecylammonium bromide (MTX-DODAB) were produced and entrapped onto P407-based nanoparticles. All formulations developed revealed a monodisperse character comprising small and narrow nanoparticles (< 100 nm). P407 nanoparticles (functionalized with FA) and MTX-P407 nanoparticles, both loaded with MTX-OEt, demonstrated a slow drug release profile. The effect of lipase from Aspergillus oryzae on the hydrolysis of the linkage between the P407 and MTX, and consequent MTX release profile, was also evaluated. We observed a controlled and slow release of MTX (< 50% of release after 11 days) in the presence of enzyme. These MTX-P407 nanoparticles loaded with MTX-OEt induced a great effect against Caco-2 cancer cells (≈40% of cell death after 72 h of incubation), demonstrating higher efficiency than the free MTX at the same concentration.

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Section: Production and Characterization Of The P407-based Nanoparticlesmentioning

confidence: 99%

Poloxamer 407 based-nanoparticles for controlled release of methotrexate

Moura

Noro

Cerqueira

et al. 2020

International Journal of Pharmaceutics

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“…Dextran is a branched polysaccharide comprised of simple repeat units of α-d-glycose joined by glycosidic bonds (32). Dextran is hydrophilic and water-soluble but can be acetylated to create a hydrophobic polysaccharide (AcDex) (33). For drug delivery, it is typically combined with crosslinkers to form a hydrogel or coating.…”

Section: Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments

Karlsson

Vaughan

Green

2018

Annu. Rev. Chem. Biomol. Eng.

176

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Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic cancer treatments by facilitating targeted delivery to a desired site. The physical and chemical properties of polymers can be tuned to accomplish delivery across the multiple biological barriers required to reach diverse subsets of cells. The use of biodegradable polymers as nanocarriers is especially attractive, as these materials can be designed to break down in physiological conditions and engineered to exhibit triggered functionality when at a particular location or activated by an external source. We present how biodegradable polymers can be engineered as drug delivery systems to target the tumor microenvironment in multiple ways. These nanomedicines can target cancer cells directly, the blood vessels that supply the nutrients and oxygen that support tumor growth, and immune cells to promote anticancer immunotherapy.

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“…26,27 To address these problems, several nanomaterial-based drug delivery systems has been developed, many of which utilize additional triggers to release curcumin. 7,14,15,[28][29][30][31] Coordination based self-assemblies of small organic ligands have shown enhanced solubility and stability of curcumin, but suffer from biocompatibility issues due to metal toxicity. 32 We tested the ability of our amphiphilic assemblies to solubilize curcumin.…”

Section: Preparation Of Samples For Tem Imagingmentioning

confidence: 99%

Amphiphilic Small Molecule Assemblies to Enhance the Solubility and Stability of Hydrophobic Drugs

Gangarde¹,

Sajeev²,

Panigrahi³

et al. 2020

Preprint

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We report the synthesis of gemini-type amphiphilic molecules that form stable assemblies in aqueous medium. The assembly property of molecule M2 in aqueous solution was first inferred from peak broadening observed in the proton NMR spectrum. This was supported by dynamic light scattering and transmission electron microscopy analysis. The assembly formed from M2 (M2agg) was used to solubilize the hydrophobic drugs curcumin and doxorubicin at physiological pH. M2agg was able to effectively solubilize curcumin as well as protect it from degradation under UV irradiation. Upon solubilization in M2agg, curcumin showed excellent cell permeability, and higher toxicity to cancer cells over normal cells, likely due to enhanced cellular uptake and increased stability. M2agg also showed pH-dependent release of doxorubicin, resulting in controlled toxicity on cancer cell lines, making it a promising candidate for the selective delivery of drugs to cancer cells.

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Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

Cited by 54 publications

References 67 publications

Poloxamer 407 based-nanoparticles for controlled release of methotrexate

Poloxamer 407 based-nanoparticles for controlled release of methotrexate

Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments

Amphiphilic Small Molecule Assemblies to Enhance the Solubility and Stability of Hydrophobic Drugs

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