New Areas of Research in Male Infertility

Mellinger, Brett C.; Goldstein, Marc

doi:10.1016/s0094-0143(21)01765-1

Urologic Clinics of North America

1987

DOI: 10.1016/s0094-0143(21)01765-1

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New Areas of Research in Male Infertility

Brett C. Mellinger

Marc Goldstein

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Cited by 5 publications

(2 citation statements)

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“…Male factor infertility remains a significant problem for ϳ50% of the patients attending infertility clinics (1,2). Clinical evaluation of the contribution of the male toward infertility of the couple is usually confirmed by total sperm count, motility, abnormal forms, and seminal parameters such as pH and antisperm antibodies.…”

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confidence: 99%

“…The study was conducted [1] to determine whether ␣6␤1 integrin expression is altered in the spermatozoa of infertile patients before and after AR with respect to motility and morphology and [2] to study the correlation between sperm integrin levels as measured by flow cytometry and ELISA with the ability of human spermatozoa to penetrate zona-free hamster eggs.…”

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confidence: 99%

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α6β1 Integrin is a potential clinical marker for evaluating sperm quality in men

Reddy

Rajeev

Gupta

2003

Fertility and Sterility

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mentioning

confidence: 99%

mentioning

confidence: 99%

α6β1 Integrin is a potential clinical marker for evaluating sperm quality in men

Reddy

Rajeev

Gupta

2003

Fertility and Sterility

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Effect of Azorellanone, a Diterpene FromAzorella yaretaHauman, on Human Sperm Physiology

Morales¹,

Kong²,

Pizarro³

et al. 2003

Journal of Andrology

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Previous studies have shown that cyclic terpenes extracted from plants decrease sperm motility and concentration in rats. In this work, we studied the effect 13-alpha-hydroxy-7-oxoazorellano (azorellanone), a cyclic diterpene extracted from Azorella yareta Hauman, on in vitro human sperm physiology. Sperm aliquots, capacitated for 4.5 or 20 hours, were incubated for 15 minutes with different concentrations of azorellanone. Then, the effects of azorellanone on sperm motility, viability, binding to the human zona pellucida, progesterone-induced acrosome reactions and increase in intracellular Ca(2)(+) concentration, and trypsin and chymotrypsin-like protease activities were evaluated. Sperm motility was evaluated according to World Health Organization (WHO) guidelines; sperm viability with the supravital dye Hoescht 33258; sperm-zona binding with the hemizona assay; progesterone-induced acrosome reaction with fluorescent lectin; intracellular Ca(2)(+) level with fura 2; and protease activity with the synthetic substrates N-t-Boc-Gln-Ala-Arg-Amido-4-methylcoumaryn and Succinyl-Leu-Leu-Val-Tyr-Amido-4-methylcoumaryn. The results obtained indicate that azorellanone inhibited sperm motility in a concentration-dependent manner at 0.15, 1.5, and 3 mM, while sperm viability was only inhibited at 3 mM. Treatment with azorellanone significantly inhibited sperm-zona binding, progesterone-induced acrosome reactions, and intracellular Ca(2)(+) concentration. Treatment of free-swimming sperm with azorellanone did not affect protease activity; however, the incubation of sperm extracts with azorellanone significantly inhibited both trypsin-like and chymotrypsin-like protease activities. In conclusion, azorellanone has a significant effect on the different parameters that characterize human sperm physiology.

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Effects of gossypol on the motility of mammalian sperm

Porat

1990

Molecular Reproduction Devel

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New Areas of Research in Male Infertility

Cited by 5 publications

References 93 publications

α6β1 Integrin is a potential clinical marker for evaluating sperm quality in men

α6β1 Integrin is a potential clinical marker for evaluating sperm quality in men

Effect of Azorellanone, a Diterpene FromAzorella yaretaHauman, on Human Sperm Physiology

Effects of gossypol on the motility of mammalian sperm

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