New Applications of Nanotechnology for Neuroimaging

Suffredini, Giancarlo; East, James E.; Levy, Lucien M.

doi:10.3174/ajnr.a3543

Cited by 16 publications

(10 citation statements)

References 72 publications

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“…(a) Polymer-drug conjugates [119], (b) Polymeric nanoparticles [120], (c) A dual-pH-sensitive polymeric micelles from self-assembling of a block copolymer-doxorubicin conjugate [92] and (d) thermo-sensitive shelf-crosslinked micelles [97], (e) FA- and PEG- functionalized nanogels for multi-drug delivery [104], and (f) thermo-responsive dendrimers [121]. Illustrations adapted with permissions from Royal Society of Chemistry for [ 121], Nature Publishing Group for [119], American Society of Neuroradiology for [120], American Chemical Society for [92] and [104], and Elsevier for [97].…”

Section: Figurementioning

confidence: 99%

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Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).

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Section: Figurementioning

confidence: 99%

“…Illustrations adapted with permissions from Royal Society of Chemistry for [ 121], Nature Publishing Group for [119], American Society of Neuroradiology for [120], American Chemical Society for [92] and [104], and Elsevier for [97]. …”

Section: Figurementioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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“…(5) The detection of neurologic diseases with targeted contrast agents and to facilitate the delivery of focused therapies to the central nervous system (Gao et al, 2013;Suffredini et al, 2013). (6) Detection systems, which can recognize mutations that can lead to cancer, and genetic markers, which can detect a predisposition to cancer (Youns et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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“…The high detection efficiency of intrinsic optical absorbers (e.g., oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) [3, 4]) enables OR-PAM to provide label-free high-resolution [5, 6] functional imaging of fine structures [7]. OR-PAM has already demonstrated broad biomedical applications in the fields of neurology [8], ophthalmology [9–12], and vascular biology [13]. However, the imaging speed of second-generation (G2) OR-PAM is insufficient for tracking certain fast dynamic activities in vivo [14].…”

mentioning

confidence: 99%

Fully motorized optical-resolution photoacoustic microscopy

Yeh

et al. 2014

Opt. Lett.

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We have developed fully motorized optical-resolution photoacoustic microscopy (OR-PAM), which integrates five complementary scanning modes and simultaneously provides a high imaging speed and a wide field of view (FOV) with 2.6 µm lateral resolution. With one-dimensional (1D) motion-mode mechanical scanning, we measured the blood flow through a cross section of a blood vessel in vivo. With two-dimensional (2D) optical scanning at a laser repetition rate of 40 kHz, we achieved a 2 kHz B-scan rate over a range of 50 µm with 20 A-lines, and 50 Hz volumetric-scan rate over a FOV of 50×50 µm2 with 400 A-lines, which enabled real-time tracking of cellular dynamics in vivo. With synchronized 1D optical and 2D mechanical hybrid scanning, we imaged a 10×8 mm2 FOV within three minutes, which is 20 times faster than the conventional mechanical scan in our second-generation OR-PAM. With three-dimensional mechanical contour scanning, we maintained the optimal signal-to-noise ratio and spatial resolution of OR-PAM while imaging objects with uneven surfaces, which is essential for quantitative studies.

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New Applications of Nanotechnology for Neuroimaging

Cited by 16 publications

References 72 publications

Evolution and clinical translation of drug delivery nanomaterials

Evolution and clinical translation of drug delivery nanomaterials

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Fully motorized optical-resolution photoacoustic microscopy

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