New Antioxidant<i> C</i>-Glucosylxanthones from the Stems of <i>Arrabidaea samydoides</i>

Pauletti, Patrícia Mendonça; Castro‐Gamboa, Ian; Silva, Dulce Helena Siqueira; Young, Maria Cláudia Marx; Tomazela, Daniela M.; Eberlin, Marcos N.; Bolzani, Vanderlan da Silva

doi:10.1021/np030100t

Cited by 67 publications

(48 citation statements)

References 14 publications

(35 reference statements)

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“…The presence of two catechol moieties on pedalitin provided even higher activity towards ABTS than for the reference compound quercetin (IC 50 4.12 mM), as observed previously for glucosyl-xanthones. 23) Similarly, this trend has also been observed for sorbifolin, which showed lower IC 50 (5.7 mM towards ABTS, and 13.5 mM towards DPPH) than its 6-O-glucosyl derivatives 1 and 4, thus confirming the importance of the 5,6-dihydroxy moiety on ring A for enhanced antiradicalar activity of 7-methoxyflavones.…”

supporting

confidence: 56%

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

et al. 2008

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supporting

confidence: 56%

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

et al. 2008

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“…3B, 2005 systems which have been deprived from sufficient amounts of endogenous antioxidants as in some cardiovascular diseases, tumors, inflammation, ulcer and aging. 9 As part of our ongoing projects aiming the phytochemical investigation of São Paulo State flora, [10][11][12] the EtOH crude extract from leaves of N. grandiflora collected at Jureia State Park, Atlantic Forest, have been subjected to bioassay-guided fractionation using the β-carotene test on TLC for the detection of antioxidant compounds. 13 Pure compounds isolated from this extract were further evaluated for their free radical scavenging activity towards the stable free radical DPPH and compared to standard compounds rutin and BHT.…”

Section: Introductionmentioning

confidence: 99%

“…13 Pure compounds isolated from this extract were further evaluated for their free radical scavenging activity towards the stable free radical DPPH and compared to standard compounds rutin and BHT. 11,14 Non-active fractions were also investigated and afforded the benzofuran neolignan burchellin and two bicyclooctane[3.2.1] neolignans: piperol B and the new 2'-oxo-piperol B.…”

Section: Introductionmentioning

confidence: 99%

A new neolignan and antioxidant phenols from Nectandra grandiflora

Ribeiro¹,

Bolzani²,

Yoshida

et al. 2005

J. Braz. Chem. Soc.

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O extrato etanólico das folhas de Nectandra grandiflora coletadas na Mata Atlântica, Brasil, mostrou atividade antioxidante frente ao β-caroteno em teste usando cromatografia em camada delgada. O fracionamento biomonitorado levou ao isolamento do ácido protocatecuico e de dois flavonóides glicosilados: afzelina e quercetrina, os quais exibiram atividade sequestradora de radicais livres frente ao DPPH (∆A 32, 16 e 73% a 50 µmol L -1 ) e foram comparados aos antioxidantes comerciais rutina (81% a 50 µmol L -1 ) e BHT (9% a 50 µmol L -1 ), usados como substâncias de referência. Além disso, três neolignanas inativas, incluindo a nova neolignana biciclo[3.2.1]octânica 2'-oxo-piperol B, foram obtidas e caracterizadas por métodos espectrométricos.The EtOH crude extract from the leaves of Nectandra grandiflora collected in the Atlantic Forest, Brazil, showed antioxidant activity towards β-carotene in a TLC assay. The bioassay-guided fractionation led to the isolation of protocatechuic acid and two flavonol glycosides: afzelin and quercetrin, which showed free radical scavenging activity towards DPPH (∆A 32, 16 and 73% at 50 µmol L -1 ) and were compared to commercial antioxidants rutin (81% at 50 µmol L -1) and BHT (9% at 50 µmol L -1 ), used as standard compounds. Additionally, three inactive neolignans, including the new bicycle[3.2.1]octane neolignan 2'-oxo-piperol B were obtained and characterized by spectrometric methods.

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“…Thus biological compounds with antioxidant properties could be expected to significantly contribute to the protection of myocardial cells and tissues against deleterious effects of ISO [11] . Nevertheless, numerous synthetic antioxidants have expressed serious limitations while showing pro-oxidant, toxic or mutagenic effects, thus, raised the attention of researchers towards the naturally derived antioxidants [12] .…”

Section: Introductionmentioning

confidence: 99%

Role of Different Doses of Vitamin E in Protection Against Isoproterenol-Induced Myocardial Damage in Adult Male Albino Rat: A Light and Electron Microscopic Study

Aboraya

Ibrahim

Qureshi

2017

Egyptian Journal of Histology

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Introduction: Cardiovascular diseases are one of the most common diseases in the world. It is essential to find an efficient natural protective agent against the myocardial damage. Aim: To determine the protective role of different doses of vitamin E against isoproterenol-induced myocardial damage. Material and Methods: Fifty adult male albino rats were divided into four main groups: Control group (I), vitamin E-treated group (II) equally divided into 2 subgroups; subgroup (IIa) received Vit E (50mg/kg) and subgroup (IIb) received Vit E (100mg/kg) for one month, isoproterenol-treated group (III) received 3ml normal saline orally for one month and isoproterenol (150mg/kg) intraperitoneally (IP) in the last two days of that month. Vitamin E and isoproterenol-treated group (IV) equally divided into two subgroups; Subgroup (IVa) received vitamin E (50mg/kg) orally for one month and isoproterenol (150mg/kg) IP in the last two days of that month and subgroup (IVb) received vitamin E (100mg/kg) orally for one month and isoproterenol (150mg/kg) IP in the last two days of that month. Heart specimens were processed for light and electron microscopic studies. Results: Rats injected by isoproterenol developed structural changes in the myocardium in the form of fragmentation of the myofibrils, vacuolated destroyed mitochondria, dilated SER, intracellular and extracellular edema and interstitial mononuclear cellular infiltration. Animals pretreated with vitamin E at a dose of 50mg/kg before injection of isoproterenol revealed minimal protection as they showed myocardial damage similar to isoproterenol-treated group. While animals pretreated with vitamin E at a dose of 100 mg/kg before injection of isoproterenol showed minimal microscopic alterations of the myocardium with preservation of the normal structure of the cardiac myocytes. Conclusion: Vitamin E at a high dose (100mg/kg) has a protective role on myocardium against isoproterenol-induced myocardial damage.

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New Antioxidant C-Glucosylxanthones from the Stems of Arrabidaea samydoides

Cited by 67 publications

References 14 publications

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

A new neolignan and antioxidant phenols from Nectandra grandiflora

Role of Different Doses of Vitamin E in Protection Against Isoproterenol-Induced Myocardial Damage in Adult Male Albino Rat: A Light and Electron Microscopic Study

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