New antibiotic-eluting mesh used for soft tissue reinforcement

Guillaume, Olivier; Lavigne, Jean‐Philippe; Lefranc, Olivier; Nottelet, Benjamin; Coudane, Jean; Garric, Xavier

doi:10.1016/j.actbio.2011.05.009

Cited by 54 publications

(57 citation statements)

References 41 publications

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“…108 As an example, coating meshes with an ofloxacincontaining poly(ε-caprolactone) demonstrated prolonged and persistent release (72 hours), against E. Coli, S. aureus, S. epidermis, 109 Enterobacteriaceae, and some Gram-positive cocci that constitute nosocomial pathogens. 110,111 Efficacy can be improved further by drug combinations to increase the antibacterial spectrum of the anti-infective mesh and reduce the risk of selecting resistant bacteria. 112,113 For example, in clinical studies, a quinolones-rifampicin combination was highly effective in preventing device-associated infections.…”

Section: Polymer Drug Carriermentioning

confidence: 99%

Prevention and treatment of biofilms by hybrid- and nanotechnologies

Kasimanickam¹,

Ranjan²,

Asokan³

et al. 2013

IJN

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Bacteria growing as adherent biofilms are difficult to treat and frequently develop resistance to antimicrobial agents. To counter biofilms, various approaches, including prevention of bacterial surface adherence, application of device applicators, and assimilation of antimicrobials in targeted drug delivery machinery, have been utilized. These methods are also combined to achieve synergistic bacterial killing. This review discusses various multimodal technologies, presents general concepts, and describes therapies relying on the principles of electrical energy, ultrasound, photodynamics, and targeted drug delivery for prevention and treatment of biofilms.

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Section: Polymer Drug Carriermentioning

confidence: 99%

Prevention and treatment of biofilms by hybrid- and nanotechnologies

Kasimanickam¹,

Ranjan²,

Asokan³

et al. 2013

IJN

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“…Therefore, the overall environmental impact is decreased, the costs reduced and the presence of solvents/by-products in the thread which can then be absorbed by the organism minimized. Poly(caprolactone) (PCL) is an aliphatic synthetic biodegradable polyester, frequently used in biomedical applications for drug controlled release (Douglas et al 2010;Guillaume et al 2011;Luong-Van et al 2006;Teo et al 2011), absorbable suture threads (Barber and Click 1992;Charuchinda et al 2003;Liu et al 2010;Perale et al 2010) and tissue engineering (Choong et al 2012;Croisier et al 2012;Li et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Combining in the melt physical and biological properties of poly(caprolactone) and chlorhexidine to obtain antimicrobial surgical monofilaments

Scaffaro

Botta

Sanfilippo

et al. 2012

Appl Microbiol Biotechnol

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Bacterial infections on a sutured wound represent a critical problem, and the preparation of suture threads possessing antimicrobial properties is valuable. In this work, poly(caprolactone) (PCL) monofilaments were compounded at the concentration of 1, 2 and 4 % (w/w), respectively, to the antiseptic chlorhexidine diacetate (CHX). The incorporation was carried out in the melt by a single-step methodology, i.e. "online" approach. Mechanical tests revealed that the incorporation of CHX does not significantly change tensile properties of PCL fibres as the thermal profile adopted to prepare the compounded fibres does not compromise the antibacterial activity of CHX. In fact, CHX confers to compounded PCL fibres' antimicrobial property even at the lowest CHX concentration as revealed by microbiological assays performed on Escherichia coli, Micrococcus luteus and Bacillus subtilis strains. The scanning electron microscope micrographs and energy-dispersive X-ray analysis of compounded threads revealed that CHX is uniformly distributed on fibre surface and that the overall amount of superficial CHX increases by increasing compounded CHX concentration. This distribution determines a biphasic CHX release kinetics characterized by an initial rapid solubilisation of superficial CHX micro-crystals, followed by a slow and gradual release of CHX incorporated in the bulk. Interestingly, the compounded threads did not show any toxic effect compromising cell viability of human fibroblasts in vitro, differently from that observed using an equal amount of pure CHX. Thus, this study originally demonstrated the effectiveness of an "online" approach to confer antimicrobial properties to an organic thermoplastic polymeric material commonly used for medical devices.

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“…Coming to the field of mesh coating, the combination of mesh with antibiotics is not new and we have seen a trend toward antibiotically impregnated suture materials in our ORs (although even here recent literature provides controversial data) [4,5]. In hernia meshes, it is still not a common property.…”

mentioning

confidence: 91%