“…RNS has limitation in applications involving arithmetic operation like scaling, overflow, division, magnitude comparisms, sign detection, overflow detection, division, reverse conversion and the complexity of the system to implement etc High speed is achieve in the operation with addition, subtraction, multiplication by supporting carry free addition, borrow free subtraction and digit to digit multiplication without partial product option for processing data in the advancing Biotechnology [4], [6]. [10] 8. Rns-Swa Based Implementation In Gene Sequence Alignment In 1981, T. F. Smith and M. S.Waterman described a method, commonly known as the Smith-Waterman (SW) algorithm [4], [15] for finding common regions of local similarity.…”