Neutrophil-Lymphocyte Ratio (Nlr) and Platelet -Lymphocyte Ratio (Plr) may be superior to C-Reactive Protein (Crp) for predicting the occurrence of differentiated thyroid cancer

Özmen, Sevilay; Timur, Özge; Çalık, İlknur; Altınkaynak, Konca; Zipak, Elif; Şimşek, Eda; Yıldız, Faruk; Sevimli, Hakan; Gozcu, Hakan; Arslan, Abdulmuttalip; Çarlıoğlu, Ayşe

doi:10.1530/endoabs.41.ep1151

Cited by 23 publications

(21 citation statements)

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“…Given the divergent mechanisms involved in the pathophysiology of these diseases, it might as well be argued that NLR and PLR are mere indicators of a general immune disorder similar to acute phase response. However since their correlation with markers of acute phase response is not consistent across studies, we reason that they probably represent a different aspect/dimension of an immune disorder other than the acute phase response [3,4,[22][23][24].…”

Section: Nlrmentioning

confidence: 87%

Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

Bilge

Yeşilova

Adaş

et al. 2018

Exp Clin Endocrinol Diabetes

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Background Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reported to be increased in various inflammation-related diseases, but their clinical significance in HT remains unclear. Objectives The aim of this study was to investigate the relationship between thyroid autommunity and NLR and PLR as markers of systemic inflammation in HT. Methods In this study, we evaluated 145 women with HT and 60 age-matched healthy controls. We compared the PLR and the NLR of HT patients with controls and the correlation between the NLR, PLR, and C-reactive protein (CRP), thyroid-stimulating hormone (TSH) and thyroid antibody titers in the patient group. Also we compared the PLR and the NLR of HT patients that received levothyroxine with those who did not receive levothyroxine Results There were no significant differences between patient and control groups in terms of overall leukocyte counts, neutrophil counts, and other laboratory tests. In the patient group lymphocyte counts were lower while the platelet counts, NLR (2.29±0.65 vs1.68±0.40), PLR (164.95±55.14 vs106.88±32.19) were higher than those of the control (p<0.001 for all comparisons). Conclusion In this study we found that NLR and PLR were higher in euthyroid Hashimoto patients than in a healthy control group. NLR and PLR are likely non-specific indicators of immune disorder and their implications for HT and other conditions remain to be elucidated.

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Section: Nlrmentioning

confidence: 87%

Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

Bilge

Yeşilova

Adaş

et al. 2018

Exp Clin Endocrinol Diabetes

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“…So NLR reflects both inflammation and stress response which are two important immune pathways. NLR has been investigated in several studies on cancer [22], cardiovascular disease [23], and thyroid disease [24,25]. But only one study so far had investigated the relationship between NLR and TN, which showed a negative association between high values of NLR and the presence or size of the nodules [26].…”

Section: Discussionmentioning

confidence: 99%

Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Liu¹,

Wang²,

Ji³

et al. 2020

Lipids Health Dis

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Background: Systemic inflammation may be involved in the formation and progression of thyroid nodule (TN). The aim of this large-scale study was to investigate the association of several simple inflammatory markers with the presence and size of TN. Methods: A total of 133,698 adults were included for the current analysis. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) were calculated. The logistic regression was used to explore the association of the four markers with the presence and size of TN. Results: The prevalence of TN was 55.1% among females and 44% among males; 13% of women and 8% of men had non-micronodule. In women, MHR and PLR were significantly associated with the presence of TN and nonmicronodule; in men, MHR and NLR were significantly associated with the presence of TN and non-micronodule. Conclusions: As a low-cost, simple, and reproducible inflammatory marker, MHR is strongly associated with the presence and size of TN irrespective of the gender.

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“…The accuracy of NLR for different cut-off values is given in Table 3. Elevated preoperative NLR has been shown to be related with incomplete response to therapy [22], poor tumor differentiation [23], lymph node invasion [24], advanced stage [25] and higher thyroglobulin values [26] in thyroid malignancies. On the other hand, in 2016, a meta-analysis of 6 prospective cohorts with 6283 differentiated thyroid cancer patients revealed no difference in NLR 6 between patients with cancer and benign nodules with a mean difference of 0.19 (95% CI: -0.09-0.46, p<0.001).…”

Section: Resultsmentioning

confidence: 99%

Value of preoperative neutrophil-to-lymphocyte ratio in predicting thyroid cancer in intermediate category fine needle aspiration pathology: retrospective study

Özdenkaya

Basım

Ölmüşçelik

et al. 2019

Preprint

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Neutrophil-Lymphocyte Ratio (Nlr) and Platelet -Lymphocyte Ratio (Plr) may be superior to C-Reactive Protein (Crp) for predicting the occurrence of differentiated thyroid cancer

Cited by 23 publications

References 0 publications

Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Value of preoperative neutrophil-to-lymphocyte ratio in predicting thyroid cancer in intermediate category fine needle aspiration pathology: retrospective study

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