Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

Bilge, Müge; Yeşilova, Aylia; Adaş, Mine; Helvacı, Ayşen

doi:10.1055/a-0723-3441

Cited by 30 publications

(31 citation statements)

References 27 publications

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“…Whereas, in a study by Cıray et al there was no difference among NLR between the patients with or without diabetic retinopathy (23). Also there are studies in which Hashimoto thyroiditis, which is one of the autoimmune thyroid diseases, is found to be signifi cantly higher than in the NLR and PLR control group (24) and before treatment than after levothroxine replacement (22). Despite the development of a similar autoimmune process with Graves' disease in Hashimoto thyroiditis, the thyroid hormone levels and the used medication are different.…”

Section: Discussionmentioning

confidence: 91%

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Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Turan¹

2019

BLL

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AIM: While the ratio of neutrophil-to-lymphocyte (NLR) increases with infl ammation, its importance in Graves' disease is not clear. The aim of this study was to evaluate NLR, a marker of chronic infl ammmation, in Graves' disease. METHODS: 86 Graves' patients (37 before treatment,49 euthyroid patients after treatment) and 112 controls were enrolled. Hematologic parameters, thyroid function tests, age and gender were recorded. NLRs were calculated. Firstly, groups were composed as Graves' group (Group1) and participants without thyroid disorder as control group (Group2). Secondly, Graves' patients before treatment were considered as Group1a, euthyroid Graves' patients after antithyroid treatment were considered as Group1b. These groups were compared with each other in terms of descriptive data and hematological parameters. RESULTS: Lymphocyte, monocyte, platelet, free T3, and free T4 levels were signifi cantly higher in Graves' group than the controls. TSH and NLR were signifi cantly lower in Graves' group Graves' than the controls. Differences among group1a and group1b for monocyte (p = 0.013), for basophil (p= 0.002), for platelet (p = 0.029), and for NLR (p = 0.029) were statistically signifi cant. CONCLUSION: Unlike other infl ammatory diseases, in Graves' disease; hematological parameters may not give information about infl ammatory state of the disease. Therefore, NLR should be evaluated with other serum infl ammatory markers in Graves' disease (Tab. 2, Fig. 1, Ref. 26).

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Section: Discussionmentioning

confidence: 91%

“…Ulu et al reported a signifi cant association between NLR and diabetic retinopathy (21). Bilge et al found that NLR and PLR were higher in euthyroid Hashimoto patients than healthy controls (22). Whereas, in a study by Cıray et al there was no difference among NLR between the patients with or without diabetic retinopathy (23).…”

Section: Discussionmentioning

confidence: 96%

Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Turan¹

2019

BLL

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“…The cross-talk between blood platelets and lymphocyte have a potent effect on thyroid gland diseases [28]. So several attempts have been made to explore the connections between PLR and thyroid tumors and thyroiditis [29,30]. However, until now, no reported research has focused on the association between PLR and TN.…”

Section: Discussionmentioning

confidence: 99%

Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Liu¹,

Wang²,

Ji³

et al. 2020

Lipids Health Dis

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Background: Systemic inflammation may be involved in the formation and progression of thyroid nodule (TN). The aim of this large-scale study was to investigate the association of several simple inflammatory markers with the presence and size of TN. Methods: A total of 133,698 adults were included for the current analysis. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) were calculated. The logistic regression was used to explore the association of the four markers with the presence and size of TN. Results: The prevalence of TN was 55.1% among females and 44% among males; 13% of women and 8% of men had non-micronodule. In women, MHR and PLR were significantly associated with the presence of TN and nonmicronodule; in men, MHR and NLR were significantly associated with the presence of TN and non-micronodule. Conclusions: As a low-cost, simple, and reproducible inflammatory marker, MHR is strongly associated with the presence and size of TN irrespective of the gender.

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“…Circulating WBCs and their classification counts will change, typically leading to lymphopenia and neutrophilia, in the presence of systemic inflammation (42,43). NLR is closely associated with most common inflammatory biomarkers, such as C-reactive protein and erythrocyte sedimentation rate (44)(45)(46)(47)(48)(49). A growing body of evidence suggests that NLR may act as excellent indicator of inflammation status in various diseases, such as Crohn's disease (49), cancer (50,51), infection (52,53), and rheumatic diseases (54)(55)(56).…”

Section: ' Discussionmentioning

confidence: 99%

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Wang¹,

Wang²,

Jia³

et al. 2020

Clinics

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Systemic lupus erythematosus (SLE) is a chronic systematic autoimmune disease. Current methods of diagnosing SLE or evaluating its activity are complex and expensive. Numerous studies have suggested that neutrophil-tolymphocyte ratio (NLR) is closely correlated with the presence of SLE and its activity, suggesting that it may serve as a diagnostic and monitoring indicator for SLE. Therefore, we performed a meta-analysis to systematically assess the association between NLR and SLE. We performed a literature search until 12 April 2019 in the PubMed, Web of Science, and China National Knowledge Infrastructure databases. Cross-sectional studies comparing the NLR of SLE patients versus those of healthy controls, of active versus inactive SLE patients, and of SLE patients with versus without lupus nephritis were considered for inclusion. Mean intergroup NLR differences were estimated using standardized mean differences and their 95% confidence intervals. Study quality was assessed using the Agency for Healthcare Research and Quality instrument for cross-sectional studies. Fourteen studies with 1,781 SLE patients and 1,330 healthy controls were included in this meta-analysis. The pooled results showed that the NLR was significantly higher in SLE patients than in healthy controls, in active SLE patients than in inactive SLE patients, and in SLE patients with lupus nephritis than in those without lupus nephritis. NLR may be an indicator for monitoring disease activity and reflecting renal involvement in SLE patients. Nevertheless, more high-quality studies are warranted to further validate our findings.

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Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

Cited by 30 publications

References 27 publications

Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

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